APC2 anticorps (Center)
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- Antigène Voir toutes APC2 Anticorps
- APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))
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Épitope
- Center
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp APC2 est non-conjugé
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Purification
- Affinity chromatography purified via peptide column
- Immunogène
- APC2 antibody was raised against an 18 amino acid peptide near the center of human APC2.
- Isotype
- IgG
- Top Product
- Discover our top product APC2 Anticorps primaire
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- Indications d'application
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ELISA. Western Blot: APC2 antibody can be used for detection of APC2 at 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS containing 0.02 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- -20 °C
- Stockage commentaire
- Store the antibody (in aliquots) at -20 °C.
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- Antigène
- APC2 (APC Regulator of WNT Signaling Pathway 2 (APC2))
- Autre désignation
- APC2 (APC2 Produits)
- Synonymes
- anticorps APCL, anticorps AI852447, anticorps R75424, anticorps APC2, WNT signaling pathway regulator, anticorps adenomatosis polyposis coli 2, anticorps APC2, anticorps Apc2
- Sujet
- Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC2 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. Like APC11, APC2 contains cullin and RING finger domains that are thought to be important in regulating ubiquitination activity.Synonyms: APC-like, APCL, Adenomatous polyposis coli protein 2, Adenomatous polyposis coli protein-like
- ID gène
- 10297
- UniProt
- O95996
- Pathways
- Signalisation WNT
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