STIM1 anticorps (C-Term)

N° du produit ABIN500827

Détail du produit anti-STIM1 anticorps

Antigène: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Épitope: C-Term

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STIM1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects STIM1 / GOK. It is predicted to have no cross-reactivity to STIM2.

Purification: Peptide affinity chromatography

Immunogène: STIM1 antibody was raised against a 24 amino acid peptide from near the carboxy terminus of human STIM1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1 - 2 μg/mL. Immunohisochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1,0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Références pour anticorps anti-STIM1 (ABIN500827)

Wu, Hsu, Wang, Liang, Tsai, Yen, Li, Chiu, Chang, Huang, Lin, Yoshioka: "A Novel Strategy for TNF-Alpha Production by 2-APB Induced Downregulated SOCE and Upregulated HSP70 in O. tsutsugamushi-Infected Human Macrophages." dans: PLoS ONE, Vol. 11, Issue 7, pp. e0159299, (2017) (PubMed).

Misceo, Holmgren, Louch, Holme, Mizobuchi, Morales, De Paula, Stray-Pedersen, Lyle, Dalhus, Christensen, Stormorken, Tjønnfjord, Frengen: "A dominant STIM1 mutation causes Stormorken syndrome." dans: Human mutation, Vol. 35, Issue 5, pp. 556-64, (2014) (PubMed).

Détails sur STIM1

Antigène: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Autre désignation: STIM1 / GOK (STIM1 Produits)

Synonymes: anticorps stim1, anticorps MGC76045, anticorps STIM1, anticorps si:dkey-24p1.5, anticorps MGC154748, anticorps si:ch211-112l17.2, anticorps Stim1, anticorps D11S4896E, anticorps GOK, anticorps TAM, anticorps SIM, anticorps stromal interaction molecule 1, anticorps stromal interaction molecule 1a, anticorps stromal interaction molecule 1 L homeolog, anticorps stromal interaction molecule 1b, anticorps STIM1, anticorps stim1, anticorps stim1a, anticorps stim1.L, anticorps stim1b, anticorps Stim1

Sujet: In T lymphocytes, the sole pathway for Ca++ entry following antigen-receptor binding is through store-operated Ca++-release-activated Ca++ (CRAC) channels. These channels are made up of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), a protein that functions as a Ca++ sensor and activates the CRAC channels, migrating to the plasma membrane from endoplasmic reticulum (ER)-like sites which act as the Ca++ store. A related molecule, STIM2, acts to inhibit the STIM1-mediated store-operated Ca++ entry, and can form complexes with STIM1, suggesting they may play a coordinated role in controlling Ca++ entry. At least two isoforms of STIM1 are known to exist, this antibody will detect only the larger form.Synonyms: Stromal interaction molecule 1

ID gène: 6786

NCBI Accession: NP_003147

Pathways: TCR Signaling, BCR Signaling