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STIM1 Produits

(Stromal Interaction Molecule 1 (STIM1))

Catégories

This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.[provided by RefSeq, Jan 2009].

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Catégories STIM1 en vedette

STIM1 Anticorps

High quality antibodies with extensive validation data.

STIM1 Kits ELISA

Reliable ELISA kits for a wide range of species.

STIM1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

STIM1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IHC (p), IF
Validations
  • (20)
  • (5)
N° du produit ABIN563045
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (5)
N° du produit ABIN7444409
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, IHC (p), IP, ICC
Validations
  • (2)
  • (3)
N° du produit ABIN192394
Quantité 0.1 mg
Fiche technique Fiche technique

STIM1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6730286
Quantité 96 tests
Fiche technique Fiche technique

STIM1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
N° du produit ABIN1321631
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3095692
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3120955
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits STIM1

Zhou, Gu, Li, Li, Zhu, Gao, Zang, Wang, Shan, Yang: "Suppression of STIM1 inhibits the migration and invasion of human prostate cancer cells and is associated with PI3K/Akt signaling inactivation." dans: Oncology reports, Vol. 38, Issue 5, pp. 2629-2636, (2018) (PubMed).

Wu, Hsu, Wang, Liang, Tsai, Yen, Li, Chiu, Chang, Huang, Lin, Yoshioka: "A Novel Strategy for TNF-Alpha Production by 2-APB Induced Downregulated SOCE and Upregulated HSP70 in O. tsutsugamushi-Infected Human Macrophages." dans: PLoS ONE, Vol. 11, Issue 7, pp. e0159299, (2017) (PubMed).

Chen, Zhang, Wu, Shi, Yan, Mei, Tolleson, Guo: "Endoplasmic Reticulum Stress and Store-Operated Calcium Entry Contribute to Usnic Acid-Induced Toxicity in Hepatic Cells." dans: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 146, Issue 1, pp. 116-26, (2015) (PubMed).

Hong, Chang, Wang, Yu, Lee: "IL-9 induces IL-8 production via STIM1 activation and ERK phosphorylation in epidermal keratinocytes: A plausible mechanism of IL-9R in atopic dermatitis." dans: Journal of dermatological science, Vol. 78, Issue 3, pp. 206-14, (2015) (PubMed).

Wang, Choi, Richardson, Reid, Seymen, Yildirim, Tuna, Gençay, Simmer, Hu: "STIM1 and SLC24A4 Are Critical for Enamel Maturation." dans: Journal of dental research, Vol. 93, Issue 7 Suppl, pp. 94S-100S, (2015) (PubMed).

Shalygin, Skopin, Kalinina, Zimina, Glushankova, Mozhayeva, Kaznacheyeva: "STIM1 and STIM2 proteins differently regulate endogenous store-operated channels in HEK293 cells." dans: The Journal of biological chemistry, Vol. 290, Issue 8, pp. 4717-27, (2015) (PubMed).

Sogkas, Stegner, Syed, Vögtle, Rau, Gewecke, Schmidt, Nieswandt, Gessner: "Cooperative and alternate functions for STIM1 and STIM2 in macrophage activation and in the context of inflammation." dans: Immunity, inflammation and disease, Vol. 3, Issue 3, pp. 154-70, (2015) (PubMed).

Tirado-Lee, Yamashita, Prakriya: "Conformational Changes in the Orai1 C-Terminus Evoked by STIM1 Binding." dans: PLoS ONE, Vol. 10, Issue 6, pp. e0128622, (2015) (PubMed).

Ma, Wei, He, Liu, Wu, Zhang, Jing, Liang, Senes, Tan, Li, Sun, Bi, Zhong, Si, Shen, Li, Lee, Zhou, Wang, Wang, Zhou: "Inside-out Ca(2+) signalling prompted by STIM1 conformational switch." dans: Nature communications, Vol. 6, pp. 7826, (2015) (PubMed).

Samanta, Kar, Mirams, Parekh: "Ca(2+) Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca(2+)-Dependent Nuclear Gene Expression." dans: Cell reports, Vol. 12, Issue 2, pp. 203-16, (2015) (PubMed).

Synonymes et noms alternatifs relatifs à STIM1

stromal interaction molecule 1 (STIM1), stromal interaction molecule 1 (stim1), stromal interaction molecule 1a (stim1a), stromal interaction molecule 1 L homeolog (stim1.L), stromal interaction molecule 1b (stim1b), stromal interaction molecule 1 (Stim1), D11S4896E, GOK, MGC76045, MGC154748, si:ch211-112l17.2, si:dkey-24p1.5, SIM, stim1, STIM1, Stim1, TAM

Protein level used designations for STIM1

  • stromal interaction molecule 1
  • stromal interaction molecule 1b
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