XBP1 anticorps (N-Term)

N° du produit ABIN501132

Détail du produit anti-XBP1 anticorps

Antigène: XBP1 (X-Box Binding Protein 1 (XBP1))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp XBP1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Réactivité croisée (Details): Species reactivity (tested):Human, mouse

Purification: Affinity chromatography

Immunogène: XBP-1 antibody was raised against a 18 amino acid peptide from near the amino terminus of human XBP-1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot. Immunohistochemistry on paraffin sections: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store the antibody (in aliquots) at -20 °C.

Détails sur XBP1

Antigène: XBP1 (X-Box Binding Protein 1 (XBP1))

Autre désignation: XBP1 / TREB5 (XBP1 Produits)

Synonymes: anticorps treb5, anticorps xXBP1, anticorps xbp2, anticorps XBP1P1, anticorps XBPP1, anticorps xbp1, anticorps TREB5, anticorps XBP-1, anticorps XBP2, anticorps D11Ertd39e, anticorps TREB-5, anticorps HTF, anticorps cb918, anticorps id:ibd1195, anticorps trebf, anticorps wu:fb02h05, anticorps wu:fb63f10, anticorps xbp1a, anticorps xbp1b, anticorps X-box binding protein 1, anticorps X-box binding protein 1 L homeolog, anticorps xbp1, anticorps XBP1, anticorps Xbp1, anticorps xbp1.L

Sujet: X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER) . Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94 (3,4).Synonyms: Tax-responsive element-binding protein 5, X-box-binding protein 1, XBP-1, XBP2

ID gène: 7494

Pathways: ER-Nucleus Signaling, Unfolded Protein Response