MAP2K6 anticorps (Mitogen-Activated Protein Kinase Kinase 6)

Details for Product anti-MAP2K6 Antibody No. ABIN681568, Fournisseur: Connectez-vous pour afficher
Antigène
  • MAPKK6
  • MEK6
  • MKK6
  • PRKMK6
  • SAPKK-3
  • SAPKK3
  • Mkk6
  • Prkmk6
  • ANQ1
  • ARABIDOPSIS NQK1
  • ARABIDOPSIS THALIANA MAP KINASE KINASE 6
  • ATMKK6
  • MAP kinase kinase 6
  • MIK19.2
  • MIK19_2
  • MKK3
  • map2k3
  • zMKK3
  • mitogen-activated protein kinase kinase 6
  • MAP kinase kinase 6
  • MAP2K6
  • Map2k6
  • MKK6
  • map2k6
Reactivité
Humain, Souris, Rat (Rattus)
193
131
96
5
4
4
2
2
1
1
1
1
1
1
1
Hôte
Lapin
171
44
2
Clonalité
Polyclonal
Conjugué
Cet anticorp MAP2K6 est non-conjugé
5
5
5
3
3
3
2
2
2
2
2
2
2
2
2
2
2
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
178
78
73
42
37
26
16
15
11
7
3
2
1
Options
Fournisseur
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Supplier Product No.
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Immunogène KLH conjugated synthetic peptide derived from human MEK6
Isotype IgG
Purification Purified by Protein A.
Autre désignation Mek6 (MAP2K6 Antibody Extrait)
Sujet

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction, and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases.

Subcellular location: Cytoplasm, Nucleus

Synonyms: MEK6, MKK6, MAPKK6, PRKMK6, SAPKK3, SAPKK-3, Dual specificity mitogen-activated protein kinase kinase 6, MAP kinase kinase 6, MAPKK 6, MAPK/ERK kinase 6, MEK 6, Stress-activated protein kinase kinase 3, SAPK kinase 3, MAP2K6, SKK3

ID gène 5608
UniProt P52564
Domaine de recherche Immunology, Innate Immunity, Tyrosine Kinases, Kinases/Phosphatases
Pathways Signalisation MAPK, Signalisation TLR, Activation of Innate immune Response, Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades
Indications d'application WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at -20°C
Date de péremption 12 months
Produit citée dans: Shi, Zhan, Zhao, Wang, Ma: "Effects of Fluoride on the Expression of p38MAPK Signaling Pathway-Related Genes and Proteins in Spleen Lymphocytes of Mice." dans: Biological trace element research, Vol. 173, Issue 2, pp. 333-8, 2016 (PubMed).

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