NEK2 anticorps (AA 1-100)
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- Antigène Voir toutes NEK2 Anticorps
- NEK2 (NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2))
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Épitope
- AA 1-100
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp NEK2 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Réactivité croisée
- Humain
- Homologie
- Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human NEK2
- Isotype
- IgG
- Top Product
- Discover our top product NEK2 Anticorps primaire
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- Indications d'application
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Date de péremption
- 12 months
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Overexpression of NIMA-related kinase 2 is associated with progression and poor prognosis of prostate cancer." dans: BMC urology, Vol. 15, pp. 90, (2015) (PubMed).
: "Examining Nek2 as a better proliferation marker in non-small cell lung cancer prognosis." dans: Tumour biology, Vol. 35, Issue 7, pp. 7155-62, (2014) (PubMed).
: "Aberrant expression of NEK2 and its clinical significance in non-small cell lung cancer." dans: Oncology letters, Vol. 8, Issue 4, pp. 1470-1476, (2014) (PubMed).
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Overexpression of NIMA-related kinase 2 is associated with progression and poor prognosis of prostate cancer." dans: BMC urology, Vol. 15, pp. 90, (2015) (PubMed).
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- Antigène
- NEK2 (NIMA (Never in Mitosis Gene A)-Related Kinase 2 (NEK2))
- Autre désignation
- NEK2 (NEK2 Produits)
- Synonymes
- anticorps AA617254, anticorps C77054, anticorps HsPK21, anticorps NEK2A, anticorps NLK1, anticorps ATNEK2, anticorps NIMA-RELATED KINASE2, anticorps NIMA-related kinase 2, anticorps T9J14.24, anticorps T9J14_24, anticorps NIMA related kinase 2, anticorps NIMA (never in mitosis gene a)-related expressed kinase 2, anticorps NIMA-related kinase 2, anticorps NEK2, anticorps Nek2
- Sujet
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Synonyms: NLK1, RP67, NEK2A, HsPK21, PPP1R111, Serine/threonine-protein kinase Nek2, HSPK 21, Never in mitosis A-related kinase 2, NimA-related protein kinase 2, NimA-like protein kinase 1, NEK2
Background: Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP25 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC8. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC2 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC, SGOL1, NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not.
- ID gène
- 4751
- UniProt
- P51955
- Pathways
- M Phase
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