DC-SIGN/CD209 anticorps (AA 389-393)
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- Antigène Voir toutes DC-SIGN/CD209 (CD209) Anticorps
- DC-SIGN/CD209 (CD209) (CD209)
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Épitope
- AA 389-393
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp DC-SIGN/CD209 est non-conjugé
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Application
- Western Blotting (WB)
- Specificité
- The antibody detects endogenous level of total CD209 (DC-SIGN) protein.
- Purification
- Affinity purified
- Immunogène
- Peptide sequence around AA 389-393 ( E-Q-F-L-S ) derived from Human CD209 (DC-SIGN) . Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
- Top Product
- Discover our top product CD209 Anticorps primaire
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- Indications d'application
- Western blotting: 1:500-1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- Antigène
- DC-SIGN/CD209 (CD209) (CD209)
- Autre désignation
- CD209 (DC-SIGN) (CD209 Produits)
- Synonymes
- anticorps CDSIGN, anticorps CLEC4L, anticorps DC-SIGN, anticorps DC-SIGN1, anticorps cd209, anticorps CLEC4M, anticorps si:ch211-224h1.3, anticorps CD209, anticorps CIRE, anticorps Dcsign, anticorps SIGN-R1, anticorps SIGNR5, anticorps Cd209, anticorps CD209 molecule, anticorps CD209a antigen, anticorps CD209 antigen-like protein D, anticorps CD209c molecule, anticorps CD209 antigen, anticorps CD209, anticorps cd209, anticorps Cd209a, anticorps LOC100529184, anticorps Cd209c, anticorps LOC100460708, anticorps LOC105484282
- Sujet
- Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA. On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.
- Poids moléculaire
- 46 kDa
- ID gène
- 30835
- NCBI Accession
- NP_066978
- UniProt
- Q9NNX6
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