STAT1 anticorps (pSer727)

N° du produit ABIN94473

Cité dans 2 publications. Cet anticorps anti-STAT1 Monoclonal Souris (Clone PSM1) (ABIN94473) détecte spécifiquement STAT1 dans WB et IP. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour STAT1 anticorps (pSer727) (ABIN94473)

Antigène: STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp STAT1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Clone: PSM1

Détail du produit anti-STAT1 anticorps

Épitope: AA 721-733, pSer727

Fonction: Anti-Hu STAT1 (pS727) Purified

Réactivité croisée (Details): Other not tested, Human

Attributs du produit: The antibody PSM1 recognizes transcriptional factor STAT1 (91 kDa) activated by phosphorylation at Ser727 (intracellular antigen).

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: STAT1 peptide sequence 721-733 (Ser727 phosphorylated).

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-STAT1 (ABIN94473)

Kovarik, Boudny, Kocak, Lauerova, Fait, Vagundova: "Malignant melanoma associates with deficient IFN-induced STAT 1 phosphorylation." dans: International journal of molecular medicine, Vol. 12, Issue 3, pp. 335-40, (2003) (PubMed).

Boudný, Kocák, Lauerová, Kovarík: "Interferon inducibility of STAT 1 activation and its prognostic significance in melanoma patients." dans: Folia biologica, Vol. 49, Issue 4, pp. 142-6, (2003) (PubMed).

Détails sur STAT1

Antigène: STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))

Autre désignation: STAT1

Sujet: Signal transducer and activator of transcription 1,STAT1 (signal transducer and activator of transcription 1) is a transcription factor that plays important roles in growth arrest, apoptosis promoting and tumour suppression. After ligation of cytokine receptors STAT1 becomes phosphorylated on Tyr701 by Janus kinase JAK1 or JAK2, dimerizes, translocates to nucleus and contacts DNA. STAT1-STAT2 heterodimers serve as more potent transcriptional inducers than STAT1 homodimers. STAT1 is also phosphorylated on Ser727 by MAPK pathway, independently of tyrosine phosphorylation. However, the both modifications are important for its maximal transcriptional activity. On the other hand, STAT1 phosphorylated on Ser727 is targeted for proteasomal degradation.,CANDF7, IMD31, ISGF3

ID gène: 6772

UniProt: P42224

Pathways: Signalistation JAK/STAT, Signalisation RTK, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events