ERCC2 anticorps (C-Term)

N° du produit ABIN966088

Détail du produit anti-ERCC2 anticorps

Antigène: ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))

Épitope: C-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERCC2 est non-conjugé

Application: Immunohistochemistry (IHC)

Purification: Purified by antigen-specific affinity chromatography.

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ERCC2(TFIIH basal transcription factor complex helicase subunit)

Information d'application

Indications d'application: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Références pour anticorps anti-ERCC2 (ABIN966088)

Coin, Marinoni, Rodolfo, Fribourg, Pedrini, Egly: "Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH." dans: Nature genetics, Vol. 20, Issue 2, pp. 184-8, (1998) (PubMed).

Détails sur ERCC2

Antigène: ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))

Autre désignation: ERCC2 (ERCC2 Produits)

Synonymes: anticorps COFS2, anticorps EM9, anticorps TTD, anticorps XPD, anticorps AA407812, anticorps AU020867, anticorps AW240756, anticorps CXPD, anticorps Ercc-2, anticorps MGC89573, anticorps CG9433, anticorps DhR3, anticorps DhXPD, anticorps DmXPD, anticorps Dmel\\CG9433, anticorps ERCC2, anticorps XPD/ERCC2, anticorps l(2)SH2 2137, anticorps l(2)SH2137, anticorps xpd, anticorps zgc:56365, anticorps ERCC excision repair 2, TFIIH core complex helicase subunit, anticorps excision repair cross-complementing rodent repair deficiency, complementation group 2, anticorps excision repair cross-complementation group 2, anticorps Xeroderma pigmentosum D, anticorps ERCC2, anticorps Ercc2, anticorps ercc2, anticorps Xpd

Sujet: ERCC2(TFIIH basal transcription factor complex helicase subunit) is an ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. ERCC2 is involved in nucleotide excision repair (NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase (CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. ERCC2 might also have a role in aging process and could play a causative role in the generation of skin cancers. One of the six subunits forming the core-TFIIH basal transcription factor. The interaction with p44 results in the stimulation of the 5'-->3' helicase activity. Defects in ERCC2 are the cause of xeroderma pigmentosum complementation group D (XP-D), xeroderma pigmentosum group D combined with Cockayne syndrome (XP-D/CS). Defects in ERCC2 are a cause of trichothiodystrophy (TTD) and COFS syndrome. ERCC2 belongs to the helicase family and RAD3/XPD subfamily.

Pathways: Réparation de l'ADN