N-Cadherin anticorps (AA 802-819)
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- Antigène Voir toutes N-Cadherin (CDH2) Anticorps
- N-Cadherin (CDH2) (Cadherin 2 (CDH2))
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Épitope
- AA 802-819
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Reactivité
- Humain, Souris, Rat, Poulet
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp N-Cadherin est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)
- Réactivité croisée
- Humain, Rat (Rattus), Poulet
- Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogène
- Mouse N-Cadherin aa. 802-819
- Clone
- 32-N
- Isotype
- IgG1
- Top Product
- Discover our top product CDH2 Anticorps primaire
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- Commentaires
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Related Products: ABIN967389, ABIN968535
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 250 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store undiluted at -20°C.
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Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses." dans: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 5345-50, (2002) (PubMed).
: "Inversin forms a complex with catenins and N-cadherin in polarized epithelial cells." dans: Molecular biology of the cell, Vol. 13, Issue 9, pp. 3096-106, (2002) (PubMed).
: "Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism." dans: Molecular biology of the cell, Vol. 12, Issue 1, pp. 27-36, (2001) (PubMed).
: "Unraveling the cytoplasmic interactions of the cadherin superfamily." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 23, pp. 10759-61, (1994) (PubMed).
: "Neural cadherin: role in selective cell-cell adhesion." dans: Science (New York, N.Y.), Vol. 245, Issue 4918, pp. 631-5, (1989) (PubMed).
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Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses." dans: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 5345-50, (2002) (PubMed).
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- Antigène
- N-Cadherin (CDH2) (Cadherin 2 (CDH2))
- Autre désignation
- N-Cadherin (CDH2 Produits)
- Synonymes
- anticorps CD325, anticorps CDHN, anticorps CDw325, anticorps NCAD, anticorps N-cadherin, anticorps cadherin-2, anticorps cdhn, anticorps ncad, anticorps cdw325, anticorps CDH2, anticorps Cadherin-2, anticorps Ncad, anticorps glo, anticorps lyr, anticorps pac, anticorps wu:fb47h04, anticorps cadherin 2, anticorps cadherin 2 S homeolog, anticorps cadherin 2, type 1, N-cadherin (neuronal), anticorps CDH2, anticorps cdh2.S, anticorps cdh2, anticorps Cdh2
- Sujet
- Cadherins are a family of Ca2+-dependent intercellular adhesion molecules that play a central role in controlling morphogenetic movements during development. Their function is regulated by association with the actin cytoskeleton by a complex of cytoplasmic proteins called the catenins (alpha, beta, gamma). Members of the cadherin family include P-cadherin, E-cadherin (uvomorulin), N-cadherin (neural cadherin), R-cadherin, cadherin 5, L-CAM, and EP-cadherin. N-cadherin mRNA is found at elevated levels in brain and heart and at a much lower level in liver. Mechanisms such as mRNA expression, cytokine modulation, and protease-mediated turnover modulate N-cadherin protein levels during development. In addition, N-cadherin function is indirectly regulated by endogenous kinases and phosphatases. Tyrosine phosphorylation of beta-catenin complexed with N-cadherin results in dissociation of N-cadherin from actin. However, N-cadherin also interacts with a PTP1B-like phosphatase that dephosphorylates beta-catenin and promotes N-cadherin/actin association. Thus, N-cadherin is an integral adhesion molecule whose function is regulated by protein-protein interactions and phosphorylation/dephosphorylation events.
- Poids moléculaire
- 130 kDa
- Pathways
- Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Synaptic Membrane
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