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Inhibin alpha anticorps

INHA Reactivité: Humain, Souris WB, ELISA, ICC Hôte: Souris Monoclonal 4-00E-02 unconjugated
N° du produit ABIN969217
  • Antigène Voir toutes Inhibin alpha (INHA) Anticorps
    Inhibin alpha (INHA) (Inhibin, alpha (INHA))
    Reactivité
    • 77
    • 64
    • 54
    • 25
    • 10
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Humain, Souris
    Hôte
    • 110
    • 21
    • 2
    Souris
    Clonalité
    • 111
    • 23
    Monoclonal
    Conjugué
    • 62
    • 21
    • 18
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp Inhibin alpha est non-conjugé
    Application
    • 107
    • 62
    • 48
    • 26
    • 26
    • 22
    • 17
    • 12
    • 11
    • 8
    • 8
    • 7
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC)
    Purification
    purified
    Immunogène
    Purified recombinant fragment of human INHA expressed in E. coli.
    Clone
    4-00E-02
    Isotype
    IgG1
  • Indications d'application
    ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    4°C, -20°C for long term storage
  • Makovitzky, Radtke, Shabani, Friese, Gerber, Mylonas: "Invasive hydatidiform mole: immunohistochemical labelling of inhibin/activin subunits, Ki67, p53 and glycodelin A in a rare case." dans: Acta histochemica, Vol. 111, Issue 4, pp. 360-5, (2009) (PubMed).

    Corre, Schuettler, Bione, Marozzi, Persani, Rossetti, Torricelli, Giotti, Vogt, Toniolo: "A large-scale association study to assess the impact of known variants of the human INHA gene on premature ovarian failure." dans: Human reproduction (Oxford, England), Vol. 24, Issue 8, pp. 2023-8, (2009) (PubMed).

    Palmieri, Wilson, Iversen, Clyde, Calingaert, Moorman, Poole, Anderson, Anderson, Anton-Culver, Beesley, Hogdall, Brewster, Carney, Chen, Chenevix-Trench, Chang-Claude, Cunningham, Dicioccio, Doherty et al.: "Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. ..." dans: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 17, Issue 12, pp. 3567-72, (2008) (PubMed).

  • Antigène
    Inhibin alpha (INHA) (Inhibin, alpha (INHA))
    Autre désignation
    INHA (INHA Produits)
    Synonymes
    anticorps si:dkey-91f15.2, anticorps INHA, anticorps MGC108500, anticorps AW555078, anticorps inhibin, alpha, anticorps inhibin alpha subunit, anticorps inhibin alpha, anticorps inhibin alpha L homeolog, anticorps inha, anticorps INHA, anticorps inha.L, anticorps Inha
    Sujet

    Description: Inhibins are peptide hormones produced by the granulosa cells in female follicles and by Sertoli cells in the male seminiferous tubules. They are selectively expressed by cells of sex cord stromal derivation, and inhibit the secretion of follitropin by the pituitary gland. Inhibins are also involved in regulating diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins, as inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibin has 2 subunits (alpha and beta) that are coded by separate genes. The alpha subunit determines whether inhibin or activin will be produced. The alpha subunit remains constant, such that the various types of inhibin are defined by the beta subunit (a,b,c,d). Inhibin A is a dimer of alpha and beta A. Inhibin B is a dimer of alpha and beta B. Proteolytic processing yields a number of inhibin alpha bioactive forms: the 20/23 kDa forms consist solely of the mature alpha chain, the 26/29 kDa forms consist of the most N terminal propeptide linked through a disulfide bond to the mature alpha chain, and the 50/53 kDa forms encompass the entire proprotein. Each type can be furthermore either mono or diglycosylated, causing the mass difference.

    Aliases: INHA

    Poids moléculaire
    40 kDa
    ID gène
    3623
    HGNC
    3623
    Pathways
    Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion
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