Aperçu des produits pour anti-Insulin Receptor Substrate 1 (IRS1) Anticorps

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anti-Insulin Receptor Substrate 1 Anticorps (IRS1)
Chez www.anticorps-enligne.fr sont 586 Insulin Receptor Substrate 1 (IRS1) Anticorps de 30 de différents fournisseurs disponibles. De plus, nous expédions Insulin Receptor Substrate 1 Kits (50) et Insulin Receptor Substrate 1 Protéines (6) et beaucoup plus de produits pour cette protéine. Un total de 666 Insulin Receptor Substrate 1 produits sont actuellement listés.
Synonymes:
G972R, HIRS-1, irs-1, IRS1, irs1-a, IRS1IRM, irsu

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anti-Insulin Receptor Substrate 1 Anticorps mieux référencés

  1. Human Polyclonal IRS1 Primary Antibody pour IHC (p), WB - ABIN196980 : Ozes, Akca, Mayo, Gustin, Maehama, Dixon, Donner: A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. dans Proceedings of the National Academy of Sciences of the United States of America 2001 (PubMed)
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  2. Human Polyclonal IRS1 Primary Antibody pour IF, IHC (p) - ABIN197466 : Tzatsos, Kandror: Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. dans Molecular and cellular biology 2005 (PubMed)
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  3. Human Polyclonal IRS1 Primary Antibody pour IF, IHC - ABIN1531876 : Simon-Szabó, Kokas, Mandl, Kéri, Csala: Metformin attenuates palmitate-induced endoplasmic reticulum stress, serine phosphorylation of IRS-1 and apoptosis in rat insulinoma cells. dans PLoS ONE 2014 (PubMed)
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  4. Human Polyclonal IRS1 Primary Antibody pour IF, ELISA - ABIN1531877 : Araki, Sun, Haag, Chuang, Zhang, Yang-Feng, White, Kahn: Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization. dans Diabetes 1993 (PubMed)

  5. Human Polyclonal IRS1 Primary Antibody pour IF (p), IHC (p) - ABIN749873 : Luo, Yang, Tang, Yao, Kong, He, Zhou: Kaempferol alleviates insulin resistance via hepatic IKK/NF-?B signal in type 2 diabetic rats. dans International immunopharmacology 2015 (PubMed)

  6. Human Polyclonal IRS1 Primary Antibody pour ELISA, WB - ABIN129580 : Shah, Hunter: Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis. dans Molecular and cellular biology 2006 (PubMed)

Plus d’anticorps contre Insulin Receptor Substrate 1 partenaires d’interaction

Pig (Porcine) Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. miR (Montrer MYLIP Anticorps)-146a-5p targets porcine insulin receptor (Montrer INSR Anticorps) and could inhibit its protein expression.

  2. TBC1D4 (Montrer TBC1D4 Anticorps), insulin receptor (Montrer INSR Anticorps) and GLUT4 (Montrer SLC2A4 Anticorps) showed altered expression in some tissues in pre-diabetic pigs.

  3. Association analysis of genotypes with growth traits, anatomy traits, meat quality traits and physiological biochemical indexes traits showed that different genotypes at locus 3,257 of IRS-1 have significant differences in carcass straight length in pigs.

Human Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. Allele and genotype frequencies of rs1801278 in IRS1 showed significant differences between cases and controls for obstructive sleep apnea risk in Chinese Han population.

  2. Gly972Arg of IRS-1 polymorphisms are associated with polycystic ovary syndrome.

  3. G allele of the rs7578326 SNP in the LOC646736/IRS1 region is significantly associated with gestational diabetes mellitus.

  4. The results suggest that high glucose compromises the insulin (Montrer INS Anticorps) signaling pathway in the glomerulus, promoting a proapoptotic environment, with a possible critical step for this malfunction lying at the level of IRS-1 phosphorylation.

  5. The C-allele of IRS1 variant rs2943650 was significantly associated with higher Body Fat Percentage overall and was significantly associated with lower levels of fasting insulin, homeostatic model assessment of insulin resistance, hemoglobin A1c, and triglycerides and higher high-density lipoprotein cholesterol in United States Hispanics/Latinos.

  6. IRS-1 and IRS-2 (Montrer IRS2 Anticorps) signaling interaction with the microtubule cytoskeleton and its response to AKT (Montrer AKT1 Anticorps) determines the response to microtubule disruption in breast carcinoma cells

  7. Findings suggest that the induction of microRNA miR (Montrer MLXIP Anticorps)-1271 by saturated fatty acid palmitate promotes the development of insulin (Montrer INS Anticorps) resistance by targeting insulin receptor (INSR (Montrer INSR Anticorps)) and insulin receptor substrate 1 protein (IRS-1) in hepatocytes.

  8. The study results were suggestive of a positive association between Gly972Arg of IRS1 and PCOS in the south Indian population, while INS (Montrer INS Anticorps), IRS2 (Montrer IRS2 Anticorps), PPAR-G (Montrer ARF6 Anticorps) and CAPN10 (Montrer CAPN10 Anticorps) failed to show any association with PCOS in our studied population.

  9. Consistent with these observations, LPIN1 (Montrer LPIN1 Anticorps) levels were positively correlated with IRS1 expression in human breast cancer. Thus, our results indicate a mechanism by which IRS1 expression is increased in breast cancer, and LPIN1 (Montrer LPIN1 Anticorps) may be a promising drug target for anticancer therapy

  10. Findings suggest that insulin receptor substrate -1 Gly972Arg polymorphism is associated with polycystic ovary syndrome in the Caucasian ethnicity, and insulin receptor substrate -2 (Montrer IRS2 Anticorps) Gly1057Asp polymorphism is correlated with polycystic ovary syndrome in the Asian ethnicity. However, insulin receptor (Montrer INSR Anticorps) His 1058 C/T polymorphism may not be implicated in polycystic ovary syndrome.

Mouse (Murine) Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. Insulin receptor substrate-1 time-dependently regulates bone formation by controlling collagen Ialpha2 expression via miR (Montrer MLXIP Anticorps)-342

  2. Irs1 was downregulated in the arcuate nucleus of type 2 diabetic mice.

  3. In conclusion, we have identified that ARL15 acts as an insulin (Montrer INS Anticorps)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1/PDPK1 (Montrer PDPK1 Anticorps)/AKT (Montrer AKT1 Anticorps) insulin (Montrer INS Anticorps) pathway by interacting with its GAP ASAP2 (Montrer ASAP2 Anticorps) and activating PDPK1 (Montrer PDPK1 Anticorps). This research may provide new insights into GTPase (Montrer RACGAP1 Anticorps)-mediated insulin (Montrer INS Anticorps) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (Montrer INS Anticorps) sensitizati

  4. These findings illuminate a new function of IRS-1: that of maintaining cells in their normal, differentiated state. Because IRS-1 is down-regulated in states of insulin (Montrer INS Anticorps) resistance that occur in response to metabolic stresses such as obesity and cytokine stimulation

  5. Decreased miR (Montrer MLXIP Anticorps)-33 levels can up-regulate IRS-2 (Montrer IRS2 Anticorps) expression, which appears to compensate for the defects of the insulin (Montrer INS Anticorps) signaling pathway in Irs-1 deficient mice.

  6. Acute knockdown of Insr (Montrer INSR Anticorps) or both Irs1 and Irs2 (Montrer IRS2 Anticorps) in adipocytes increased Adipoq (Montrer ADIPOQ Anticorps) mRNA expression but reduced adiponectin (Montrer ADIPOQ Anticorps) secretion.

  7. Concentration of SOCS-3 (Montrer SOCS3 Anticorps) protein and coimmunoprecipitation of SOCS-3 (Montrer SOCS3 Anticorps) protein with both the IR-beta subunit (Montrer POLG Anticorps) as well as IRS-1 was found to be decreased by 4-HIL

  8. Authors propose that insulin (Montrer INS Anticorps)/IGF-1 (Montrer IGF1 Anticorps) cross talk and level of phosphorylation of specific IRS-1 serines may promote the Ames dwarf (Montrer PROP1 Anticorps) longevity phenotype.

  9. within the hepatic compartment, mTORC1 --> S6K (Montrer RPS6KB1 Anticorps) signaling regulates Akt (Montrer AKT1 Anticorps) largely through IRS (Montrer IARS Anticorps)-independent means with little effect upon physiologic insulin (Montrer INS Anticorps) sensitivity.

  10. Sustained overexpression of HBx and IRS1 led to constitutive activation of a tripartite growth factor signal transduction cascade in the liver and was necessary and sufficient to promote HCC (Montrer FAM126A Anticorps) development and progression.

Rabbit Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. IRS1 gene was associated with growth traits in rabbits.Association between the IRS1 and FTO (Montrer FTO Anticorps) genes regulates body weight in rabbits.

Xenopus laevis Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. Knock down of IRS-1 in neural tissue by specific antisense morpholino oligonucleotides (MO) resulted in abnormal eye formation accompanied by reduction of the eye-specific marker genes Rx1 and Pax6 (Montrer PAX6 Anticorps) and a decreased cell proliferation.

Insulin Receptor Substrate 1 (IRS1) profil antigène

Antigen Summary

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Alternative names and synonyms associated with Insulin Receptor Substrate 1 (IRS1)

  • insulin receptor substrate 2 (irs2) anticorps
  • insulin receptor substrate 1 (IRS1) anticorps
  • insulin receptor substrate 1 (Irs1) anticorps
  • insulin receptor substrate 1 (irs1) anticorps
  • G972R anticorps
  • HIRS-1 anticorps
  • irs-1 anticorps
  • IRS1 anticorps
  • irs1-a anticorps
  • IRS1IRM anticorps
  • irsu anticorps

Protein level used designations for IRS1

IRS-1 , insulin receptor substrate 1 , pp185 , XIRS-L , insulin receptor substrate 1-A , xIRS-1-A

GENE ID SPECIES
394823 Xenopus (Silurana) tropicalis
429126 Gallus gallus
459985 Pan troglodytes
100271862 Felis catus
100294708 Sus scrofa
100607873 Nomascus leucogenys
3667 Homo sapiens
16367 Mus musculus
25467 Rattus norvegicus
429262 Gallus gallus
538598 Bos taurus
100512686 Sus scrofa
100716939 Cavia porcellus
486148 Canis lupus familiaris
100339981 Oryctolagus cuniculus
101102293 Ovis aries
399299 Xenopus laevis
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