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RasGRP1 is indispensable for development of B1a cells with autoantigen receptors, revealing a connection between a signaling molecule and development of a specific repertoire within the B1a cell population
Genetic Rasgrp1 depletion from mice with either an activating mutation in KRas or with aberrant Wnt (Montrer WNT2 Anticorps) signalling due to a mutation in Apc (Montrer APC Anticorps) resulted in both cases in exacerbated Ras-ERK (Montrer EPHB2 Anticorps) signalling and cell proliferation.
CD44 (Montrer CD44 Anticorps) expression, CD4 (Montrer CD4 Anticorps)(+) T cell subset ratios and serum autoantibodies all returned to normal in Rasgrp1(Anaef)Mtor (Montrer FRAP1 Anticorps)(chino) double-mutant mice
RasGRP1 upregulates signaling from Ras and contributes to epidermal tumorigenesis by increasing the total dosage of active Ras.
autoreactive B cells lacking Rasgrp1 break central and peripheral tolerance through both T cell-independent and -dependent mechanisms.
Dysregulated RasGRP1 responds to cytokine receptor (Montrer LEPR Anticorps) input in T cell leukemogenesis.
RasGRP1, but not RasGRP3 (Montrer RASGRP3 Anticorps), is required for thymocyte positive selection and invariant natural killer T cell selection.
Genetic analysis shows that disease progression and ERK (Montrer EPHB2 Anticorps) signaling are dependent on RAS guanine exchange factor (Montrer SOS1 Anticorps) responsible for ERK (Montrer EPHB2 Anticorps) activation and lymphoproliferative phenotype in LAT (Montrer LAT Anticorps)-Y136F mutant mice.
While the DAG-binding C1 domain of RasGRP1 has long been recognized as an important factor mediating Erk (Montrer EPHB2 Anticorps) activation, we have revealed the physiological relevance of the tail domain in RasGRP1 function and control of Erk (Montrer EPHB2 Anticorps) signaling
assessed the independent and combined roles for the RasGEFs Sos1 (Montrer SOS1 Anticorps), Sos2 (Montrer SOS2 Anticorps), and RasGRP1 during thymocyte development
This study shows that deficiency in RASGRP1 results in a previously unknown primary immunodeficiency disease, and that RASGRP1 plays role in immune cell signaling and function in T cells, B cells and NK cells. It also identifies a previously unknown role for RASGRP1 in the dynamic regulation of the cytoskeleton, and identify lenalidomide as a potpotential treatment option for this immunodeficiency.
This study aimed to replicate and verify the association of RASGRP1 tag single-nucleotide polymorphisms with T2D in a Chinese Han population.
present a crystal structure of a fragment of RasGRP1 in which the Ras-binding site is blocked by an interdomain linker and the membrane-interaction surface of RasGRP1 is hidden within a dimerization interface
A genome-wide association study identifies GRK5 (Montrer GRK5 Anticorps) and RASGRP1 as type 2 diabetes loci in Chinese Hans.
This is the first study aimed at evaluating CalDAG-GEFI gene sequences in people with mucocutaneous bleeding of unknown cause.
PAQR10 and PAQR11 are able to interact with RasGRP1, a guanine nucleotide exchange protein of Ras, and increase Golgi localization of RasGRP1. The C1 domain of RasGRP1 is both necessary and sufficient for the interaction of RasGRP1 with PAQR10/PAQR11.
cooperation between aberrant expression of RasGRP1, a strong activator of Ras, and secondary gain-of-function mutations of NOTCH1 (Montrer NOTCH1 Anticorps) have an important role in T-cell leukemogenesis
remission in systemic lupus erythematosus activity associated with decreased RasGRP-1 expression in lymphocytes
Basal LAT-diacylglycerol-RasGRP1 signals in T cells maintain TCRalpha gene expression.
SDF-1 (Montrer CXCL12 Anticorps) treatment of T cells induced the formation of a novel molecular signaling complex containing RasGRP1, Galphai2 (Montrer GNAI2 Anticorps), and ZAP-70 (Montrer ZAP70 Anticorps).
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).
RAS guanyl-releasing protein 1
, calcium and DAG-regulated guanine nucleotide exchange factor II
, RAS guanyl nucleotide-releasing protein 1
, guanine nucleotide exchange factor, calcium- and DAG-regulated, Rap1A
, ras activator RasGRP