Aperçu des produits pour MAP2K2 Protéines (MAP2K2)

Full name:
Mitogen-Activated Protein Kinase Kinase 2 Protéines (MAP2K2)
Chez www.anticorps-enligne.fr sont 21 Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) Protéines de 10 de différents fournisseurs disponibles. De plus, nous expédions MAP2K2 Anticorps (268) et MAP2K2 Kits (10) et beaucoup plus de produits pour cette protéine. Un total de 316 MAP2K2 produits sont actuellement listés.
Synonymes:
AA589381, ATMKK2, CFC4, F27B13.50, F27B13_50, MAP KINASE KINASE 1, MAP kinase kinase 2, MAPKK2, MEK2, MK1, MK2, MKK2, PRKMK2
afficher tous les protéines Gène GeneID UniProt
MAP2K2 58960 P36506
MAP2K2 5605 P36507
MAP2K2 26396 Q63932

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MAP2K2 Protéines (MAP2K2) par origine

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MAP2K2 Protéines mieux référencés

  1. Human MAP2K2 Protein expressed in Escherichia coli (E. coli) - ABIN1098267 : Crews, Alessandrini, Erikson: The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. dans Science (New York, N.Y.) 1992 (PubMed)
    Show all 2 references for 1098267

  2. Human MAP2K2 Protein expressed in Wheat germ - ABIN1310169 : Brady, Crowe, Turski, Hobbs, Yao, Chaikuad, Knapp, Xiao, Campbell, Thiele, Counter: Copper is required for oncogenic BRAF signalling and tumorigenesis. dans Nature 2014 (PubMed)

Plus protéines pour MAP2K2 partenaires d'interaction

Human Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) interaction partners

  1. High MEK2 expression is associated with inflammation.

  2. there were significant decreases in intercellular adhesion molecules 1 (ICAM1 (Montrer ICAM1 Protéines)), ezrin (EZR (Montrer EZR Protéines)), mitogen-activated protein kinase kinase 2 (MAP2K2), and nitric oxide synthase 3 (NOS3 (Montrer NANOS3 Protéines)) gene expressions in metabolic syndrome patients.

  3. The patient showed a paternally inherited 16p13.11 microduplication and a de novo 19p13.3 microdeletion involving the mitogen-activated protein kinase kinase 2 gene (MAP2K2), in which mutations cause the cardio-facio-cutaneous (CFC (Montrer PTPN11 Protéines)) syndrome

  4. Data show that mitogen-activated protein kinase (Montrer MAPK1 Protéines) kinases MEK1 (Montrer MAP2K1 Protéines)/2 inhibitor pimasertib (MEKI) sensitized the cells to apoptosis through its ability to promote a G1 cell cycle arrest.

  5. the purpose of this paper was to investigate MAPK (Montrer MAPK1 Protéines) downstream signalling molecules in Natural killer cell phenotypes from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients.

  6. at clinically relevant concentrations, cDDP binds to and inhibits MEK1 (Montrer MAP2K1 Protéines)/2 and both the binding and inhibitory activity are related to its interaction with Cu bound to MEK1 (Montrer MAP2K1 Protéines)/2

  7. Endocytosis separates EGF (Montrer EGF Protéines) receptors from endogenous fluorescently labeled HRas (Montrer HRAS Protéines) and diminishes receptor signaling to MAP kinases in endosomes.

  8. MEK1 (Montrer MAP2K1 Protéines) levels are upregulated at transcriptional level whereas MEK2 levels are downregulated at posttranslational level.

  9. MEK1/2 inhibitor trametinib showed similar PFS and a response rate as docetaxel in patients with previously treated KRAS-mutant-positive non-small cell lung carcinoma.

  10. We report on a fourth familial case with transmission of CFC (Montrer PTPN11 Protéines) syndrome from father to son due to a novel heterozygous sequence change c.376A>G (p.N126D) in exon 3 of MEK2 gene.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) interaction partners

  1. FGF2 (Montrer FGF2 Protéines) is an extracellular inducer of COUP-TFII (Montrer NR2F2 Protéines) expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII (Montrer NR2F2 Protéines) expression prior to the onset of osteogenic differentiation

  2. REDD1 (Montrer DDIT4 Protéines) is required for normal insulin (Montrer INS Protéines)-stimulated signaling, and a subtle balance exists between MEK1 (Montrer MAP2K1 Protéines)/2, REDD1 (Montrer DDIT4 Protéines), and mTOR (Montrer FRAP1 Protéines)

  3. MEK1 (Montrer MAP2K1 Protéines) and MEK2 can substitute for each other but a minimum amount of MEK (Montrer MDK Protéines) is critical for placenta development and embryo survival

  4. MK2 (Montrer KCNA2 Protéines)/3 cascade plays a strategic role in controlling synaptic plasticity and cognition.

  5. MK2 (Montrer KCNA2 Protéines) attenuates dendritic cell-mediated Th1 (Montrer HAND1 Protéines) differentiation and autoimmune encephalomyelitis.

  6. analysis of p38 (Montrer CRK Protéines)-MK2 (Montrer KCNA2 Protéines)-activated Rsk (Montrer RPS6KA1 Protéines) signaling in toll (Montrer TLR4 Protéines)-like receptor-stimulated dendritic cells

  7. both MEK1 (Montrer MAP2K1 Protéines) and MEK2 have crucial roles in the integration of mesenchymal and epithelial signals essential for the development of the entire respiratory tract

  8. MK2 (Montrer KCNA2 Protéines) is responsible for resistance of p53 (Montrer TP53 Protéines)-deficient tumors to cisplatin

  9. MK2 (Montrer KCNA2 Protéines) plays a critical role in the development of apoptosis.

  10. rapamycin treatment led to an increased MKP1 (Montrer DUSP1 Protéines) expression in BMDM from WT but failed to do so in BMDMs lacking the AKT1 (Montrer AKT1 Protéines) isoform or MEK1 (Montrer MAP2K1 Protéines) and MEK2.

Arabidopsis thaliana Mitogen-Activated Protein Kinase Kinase 2 (MAP2K2) interaction partners

  1. the AtMKK2-AtMPK10 (Montrer MAPK10 Protéines) MAPK (Montrer MAPK1 Protéines) module regulates leaf venation complexity by altering polar auxin transport efficiency

  2. Treatment of Arabidopsis with a membrane rigidifier, DMSO, causes MPK4 (Montrer MAPK4 Protéines) activation concomitantly with MEKK1 (Montrer MAP3K1 Protéines) and MKK2 phosphorylation.

  3. Ca(2 (Montrer CA2 Protéines)+) signaling occurred upstream of the MEKK1 (Montrer MAP3K1 Protéines)-MKK2 pathway. MEKK1 (Montrer MAP3K1 Protéines) was phosphorylated by calcium/calmodulin (Montrer CALM Protéines)-regulated receptor-like kinase (CRLK1), which suggested that CRLK1 is one of candidates located upstream of MEKK1 (Montrer MAP3K1 Protéines).

  4. Data indicate that MEKK2 (Montrer MAP3K2 Protéines) is required for the mekk1 (Montrer MAP3K1 Protéines), mkk1 (Montrer MAP2K1 Protéines) mkk2, and mpk4 (Montrer MAPK4 Protéines) autoimmune phenotypes.

  5. Data suggest that the MEKK1 (Montrer MAP3K1 Protéines)-MKK1 (Montrer MAP2K1 Protéines)/MKK2-MPK4 (Montrer MAPK4 Protéines) kinase cascade negatively regulates MEKK2 (Montrer MAP3K2 Protéines) and activation of MEKK2 (Montrer MAP3K2 Protéines) triggers SUMM2-mediated immune responses.

  6. Data indicate that MKK2 plays a role in abiotic stress tolerance and plant disease resistance.

  7. double loss-of-function mutant (mkk1 (Montrer MAP2K1 Protéines)/2) of MKK1 (Montrer MAP2K1 Protéines) and MKK2 is shown to have marked phenotypes in development and disease

  8. Activation of MPK4 (Montrer MAPK4 Protéines) by flg22 is impaired in the mkk1 (Montrer MAP2K1 Protéines) mkk2 double mutants, suggesting that MKK1 (Montrer MAP2K1 Protéines) and MKK2 function together with MPK4 (Montrer MAPK4 Protéines) and MEKK1 (Montrer MAP3K1 Protéines) in a MAP kinase (Montrer MAPK1 Protéines) cascade to negatively regulate innate immune responses in plants.

Profil protéine MAP2K2

Profil protéine

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Alternative names and synonyms associated with MAP2K2

  • mitogen activated protein kinase kinase 2 (Map2k2)
  • mitogen-activated protein kinase kinase 2 (MAP2K2)
  • mitogen-activated protein kinase kinase 2 (Map2k2)
  • mitogen-activated protein kinase kinase 2 (MKK2)
  • AA589381 Protéine
  • ATMKK2 Protéine
  • CFC4 Protéine
  • F27B13.50 Protéine
  • F27B13_50 Protéine
  • MAP KINASE KINASE 1 Protéine
  • MAP kinase kinase 2 Protéine
  • MAPKK2 Protéine
  • MEK2 Protéine
  • MK1 Protéine
  • MK2 Protéine
  • MKK2 Protéine
  • PRKMK2 Protéine

Protein level used designations for MAP2K2

ERK activator kinase 2 , MAP kinase kinase 2 , MAPK/ERK kinase 2 , MAPKK 2 , MEK 2 , MEK2 , dual specificity mitogen-activated protein kinase kinase 2 , mitogen-activated protein kinase kinase 2, p45 , MAP kinase/Erk kinase , mitogen activated protein kinase kinase 2 , protein kinase, mitogen activated, kinase 2, p45 , dual specificity mitogen activated protein kinase kinase 2 , mitogen-activated protein kinase kinase type 2

GENE ID SPECIES
58960 Rattus norvegicus
5605 Homo sapiens
26396 Mus musculus
611939 Canis lupus familiaris
396349 Gallus gallus
510434 Bos taurus
829103 Arabidopsis thaliana
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