Aperçu des produits pour anti-MAP3K4 (MAP3K4) Anticorps

Full name:
anti-Mitogen-Activated Protein Kinase Kinase Kinase 4 Anticorps (MAP3K4)
Chez www.anticorps-enligne.fr sont 81 Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) Anticorps de 16 de différents fournisseurs disponibles. De plus, nous expédions MAP3K4 Protéines (5) et beaucoup plus de produits pour cette protéine. Un total de 90 MAP3K4 produits sont actuellement listés.
D17Rp17, D17Rp17e, MAPKKK4, Mek4b, MEKK 4, Mekk4, mKIAA0213, MTK1, PRO0412, RP17, Rp17a, Tas
afficher tous les anticorps Gène GeneID UniProt
MAP3K4 308106  
MAP3K4 4216 Q9Y6R4
MAP3K4 26407 O08648

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anti-Rat (Rattus) MAP3K4 Anticorps:

anti-Human MAP3K4 Anticorps:

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anti-MAP3K4 Anticorps mieux référencés

  1. Human Polyclonal MAP3K4 Primary Antibody pour EIA, IHC (p) - ABIN953298 : Grucza, Johnson, Krueger, Breslau, Saccone, Chen, Derringer, Agrawal, Lynskey, Bierut: Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes. dans Addiction biology 2010 (PubMed)
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  2. Human Monoclonal MAP3K4 Primary Antibody pour WB - ABIN393852 : Whitmarsh, Davis: Role of mitogen-activated protein kinase kinase 4 in cancer. dans Oncogene 2007 (PubMed)
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Plus d’anticorps contre MAP3K4 partenaires d’interaction

Human Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) interaction partners

  1. IL-21 (Montrer IL17C Anticorps) expression is promoted by MEKK4 in malignant T cells and is associated with progression risk in cutaneous T-cell lymphoma

  2. Mutations in genes such as AKT2 (Montrer AKT2 Anticorps), CCNA1 (Montrer CCNA1 Anticorps), MAP3K4, and TGFBR1 (Montrer TGFBR1 Anticorps), were associated significantly with Epstein-Barr-positive gastric tumors, compared with EBV-negative tumors.

  3. Map3k4 haploinsufficiency is the cause of T-associated sex reversal.

  4. MTK1 was identified in the HER2 (Montrer ERBB2 Anticorps)/HER3 (Montrer ERBB3 Anticorps)-HRG (Montrer NRG1 Anticorps) mediated extracellular acidification and cell migration pathway in breast cancer cells.

  5. MAP3K4 is sufficiently mediate the TGFbeta (Montrer TGFB1 Anticorps)-induced phosphorylation of p38 MAPK (Montrer MAPK14 Anticorps) in MEFs and HaCaT cells.

  6. we have identified a reduced IL-1A (Montrer IL1A Anticorps) response, related to a low MAP3K4 expression and high expression of its inhibitor GSK3beta (Montrer GSK3b Anticorps), identifying a novel key player in Crohn's disease.

  7. For the first time we report a significant association between nicotine dependence and DRD5 (Montrer DRD5 Anticorps), NPY1R (Montrer NPY1R Anticorps) MAP3K4 single nucleotide polymorphism.

  8. The upstream molecule of the TRAIL-induced MAPK (Montrer MAPK1 Anticorps) activation is MEKK (Montrer MAP3K1 Anticorps), as opposed to ASK1 (Montrer MAP3K5 Anticorps), via the mediation of its signal through JNK (Montrer MAPK8 Anticorps)/p38 (Montrer CRK Anticorps) in a caspase-8 (Montrer CASP8 Anticorps)-dependent manner.

  9. CIN85 (Montrer SH3KBP1 Anticorps) binding to a C-terminal motif within hTTP leads to the increased phosphorylation of hTTP, possibly through enhanced association with MEKK4

  10. Axin (Montrer AXIN1 Anticorps) utilizes distinct regions for competitive MEKK1 (Montrer MAP3K1 Anticorps) and MEKK4 binding and JNK (Montrer MAPK8 Anticorps) activation.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4) interaction partners

  1. by forming a complex with MEKK4 in skeletal muscle fibers, Gadd45a (Montrer GADD45A Anticorps) increases MEKK4 protein kinase (Montrer CDK7 Anticorps) activity, which is both sufficient to induce skeletal muscle fiber atrophy and required for Gadd45a (Montrer GADD45A Anticorps)-mediated skeletal muscle fiber atrophy.

  2. Map3k4 haploinsufficiency is the cause of T-associated sex reversal.

  3. suggest a requirement for GADD45gamma (Montrer GADD45G Anticorps) in promoting MAP3K4-mediated activation of p38 MAPK (Montrer MAPK14 Anticorps) signaling in embryonic gonadal somatic cells for testis determination

  4. MTK1 plays an important role in the regulation of cell death and is also involved in the pathogenesis of heart failure.

  5. During Th1 (Montrer HAND1 Anticorps) differentiation, the GADD45beta (Montrer GADD45B Anticorps)/GADD45gamma (Montrer GADD45G Anticorps)/MEKK4 pathway integrates upstream signals transduced by both T cell receptor and IL12 (Montrer IL12A Anticorps)/STAT4 (Montrer STAT4 Anticorps), leading to augmented interferon-gamma (Montrer IFNG Anticorps) production in a process independent of STAT4 (Montrer STAT4 Anticorps).

  6. MEKK4 plays a critical role in regulating MKK4 (Montrer MAP2K4 Anticorps) activity and apoptotic cell death during neural tube development.

  7. MEKK4 is the MAPK (Montrer MAPK1 Anticorps) kinase kinase for TRAF4 (Montrer TRAF4 Anticorps) regulation of the JNK (Montrer MAPK8 Anticorps) pathway

  8. Hindbrains of exencephalic MEKK4(K1361R) embryos show a striking increase in neuroepithelial cell apoptosis and a dramatic loss of phosphorylation of MKK3 (Montrer MAP2K3 Anticorps) and -6, mitogen-activated protein kinase (Montrer MAPK1 Anticorps) kinases (MKKs (Montrer MKKS Anticorps)) regulated by MEKK4 in the p38 (Montrer CRK Anticorps) pathway.

  9. MEKK4 regulates epithelial-to-mesenchymal transition in the endocardial cushions of the developing heart.

  10. our results demonstrate a link between MEKK4 and filamin-a (Montrer FLNA Anticorps) that impacts neuronal migration initiation

MAP3K4 profil antigène

Antigen Summary

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described.

Alternative names and synonyms associated with MAP3K4

  • mitogen activated protein kinase kinase kinase 4 (Map3k4) anticorps
  • mitogen-activated protein kinase kinase kinase 4 (MAP3K4) anticorps
  • mitogen-activated protein kinase kinase kinase 4 (Map3k4) anticorps
  • D17Rp17 anticorps
  • D17Rp17e anticorps
  • MAPKKK4 anticorps
  • Mek4b anticorps
  • MEKK 4 anticorps
  • Mekk4 anticorps
  • mKIAA0213 anticorps
  • MTK1 anticorps
  • PRO0412 anticorps
  • RP17 anticorps
  • Rp17a anticorps
  • Tas anticorps

Protein level used designations for MAP3K4

mitogen-activated protein kinase kinase kinase 4 , MAP three kinase 1 , MAP/ERK kinase kinase 4 , MAPK/ERK kinase kinase 4 , MEK kinase 4 , MEKK 4 , SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of , dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4) , predicted protein of HQ0412 , T-associated sex reversal , mitogen activated protein kinase kinase kinase 4

308106 Rattus norvegicus
4216 Homo sapiens
26407 Mus musculus
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