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Human PAK2 Protein expressed in Wheat germ - ABIN1313923
Lacombe, Mangé, Jarlier, Bascoul-Mollevi, Rouanet, Lamy, Maudelonde, Solassol: Identification and validation of new autoantibodies for the diagnosis of DCIS and node negative early-stage breast cancers. dans International journal of cancer. Journal international du cancer 2013
EphrinB ligands B2a and B3b, the Ephb4a (Montrer EPHB4 Protéines) receptor and the Pak2a kinase are required for the development of pharyngeal pouches and the segmentation of the posterior facial skeleton.
Essential in vivo role for betaPix (Montrer ARHGEF7 Protéines) and Pak2a during embryonic development and a previously unrecognized pathway specifically involved in cerebrovascular stabilization. [BetaPix (Montrer ARHGEF7 Protéines) AND Pak2a]
Data provide evidence for a critical function of Pak2 in vascular integrity and demonstrate a severe disease phenotype resulting from loss of Pak2 function.
leukaemic cells explicitly require PAK2 to grow towards an extracellular matrix. PAK2-deficient cells fail to form colonies in methylcellulose and to induce lymphomas in vivo. PAK2 might therefore be the critical isoform in leukaemic cells by controlling tumour growth
Results show that PAK2 kinase plays an alternative anti-apoptotic role, phosphorylating caspase-7 (Montrer CASP7 Protéines) and promoting unfettered cell growth and chemotherapeutic resistance.
We found that overexpression of miR (Montrer MLXIP Protéines)-137 inhibited the proliferation of melanoma cells, which could be phenocopied by knockdown of PAK2 using siRNAs.
PAK2 is a direct effector of TSC1 (Montrer TSC1 Protéines)-TSC2-RHEB (Montrer RHEB Protéines) signaling and a new target for rational drug therapy in TSC (Montrer SLC12A3 Protéines).
Nef exploits PAK2 in a stepwise mechanism in which its kinase activity cooperates with an adaptor function for the exocyst complex to inhibit host cell actin dynamics.
Cytoplasmic Pak2 may promote cell proliferation in normal endometrium during menstrual cycle.
Further analyses show that HDAC6 (Montrer HDAC6 Protéines) may promote growth of GBM cells through inhibition of SMAD2 (Montrer SMAD2 Protéines) phosphorylation to downregulate p21 (Montrer CDKN1A Protéines)
Pak1 (Montrer PAK1 Protéines) and Pak2 counteract centrosome separation in a kinase-dependent manner.
Findings indicate that repression of microRNA miR (Montrer MLXIP Protéines)-134 and consequent up-regulation of p21-activated kinase 2 (Pak2) might contribute to paclitaxel resistance.
Inhibition of PAK activation at late G2-phase centrosomes caused by Rac1 inactivation coincides with impeded activation of Aurora A (Montrer AURKA Protéines) and the CyclinB (Montrer CCNB1 Protéines)/Cdk1 (Montrer CDK1 Protéines) complex and delayed mitotic entry.
PAK2 acts as a Rac1-dependent negative regulator of neuronal glucose uptake and insulin (Montrer INS Protéines) sensitivity.
These results identify Pak1 (Montrer PAK1 Protéines) and Pak2 as redundant regulators of myoblast differentiation in vitro and in vivo and as components of the promyogenic Ncad (Montrer CDH2 Protéines)/Cdo (Montrer CDO1 Protéines)/Cdc42 (Montrer CDC42 Protéines) signaling pathway.
PAK-mediated phosphorylation of PKD1 at Ser203 triggers its membrane dissociation and subsequent entry into the nucleus, thereby regulating the phosphorylation of PKD1 nuclear targets, including class IIa histone deacetylases.
Data indicate that resveratrol treatment inhibits neuronal glucose uptake via P21-activated kinase 2 (PAK2).
Mechanistic insights into the role of Pak2 in hematopoietic stem cells migration and homing.
Pak2 disruption decreased the survival and proliferation of multicytokine stimulated immature progenitors.
The data suggest that Pak2 controls thymic Natural Killer T-cell development by providing a signal that links Egr2 (Montrer EGR2 Protéines) to induce PLZF (Montrer ZBTB16 Protéines), in part by regulating signaling lymphocyte activation molecule (Montrer SLAMF1 Protéines) 6 expression.
In adult endothelial cells, Pak2 depletion leads to severe apoptosis and acute angiogenesis defects, and in adult mice, endothelial Pak2 deletion leads to increased vascular permeability.
Pak2 Links TCR Signaling Strength to the Development of Regulatory T Cells and Maintains Peripheral Tolerance
Failure to induce proper actin cytoskeletal remodeling impaired PLCgamma1 and Erk1/2 signaling in the absence of Pak2, uncovering the critical function of Pak2 as an essential regulator that governs the actin cytoskeleton-dependent signaling
Basement membrane proteins promote PAK2 Ser (Montrer SIGLEC1 Protéines)-20 phosphorylation through enhanced eNOS (Montrer NOS3 Protéines) activation and NO production.
The p21 activated kinases (PAK) are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. The PAK proteins are a family of serine/threonine kinases that serve as targets for the small GTP binding proteins, CDC42 and RAC1, and have been implicated in a wide range of biological activities. The protein encoded by this gene is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating the apoptotic events in the dying cell.
p21 (CDKN1A)-activated kinase 2
, p21-activated kinase 2
, serine/threonine-protein kinase PAK 2
, p21 activated kinase 2
, S6/H4 kinase
, p21-activated kinase I
, p21-activated protein kinase I