Aperçu des produits pour anti-HER2 (ERBB2) Anticorps

Full name:
anti-V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) Anticorps (ERBB2)
Chez www.anticorps-enligne.fr sont 1582 V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Anticorps de 44 de différents fournisseurs disponibles. De plus, nous expédions HER2 Protéines (101) et HER2 Kits (48) et beaucoup plus de produits pour cette protéine. Un total de 1815 HER2 produits sont actuellement listés.
Synonymes:
c-erbB2, c-neu, CD340, Erbb-2, HER-2, HER-2/neu, HER2, mKIAA3023, MLN 19, Neu, NGL, TKR1
afficher tous les anticorps Gène GeneID UniProt
ERBB2 24337  
ERBB2 2064 P04626
ERBB2 13866 P70424

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Tous anti-HER2 Anticorps disponible

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anti-HER2 Anticorps mieux référencés

  1. Human Monoclonal HER2 Primary Antibody pour IHC (p) - ABIN1688892 : Savci-Heijink, Halfwerk, Hooijer, Horlings, Wesseling, van de Vijver: Retrospective analysis of metastatic behaviour of breast cancer subtypes. dans Breast cancer research and treatment 2015 (PubMed)
    Show all 50 references for 1688892

  2. Human Monoclonal HER2 Primary Antibody pour IF, IHC (p) - ABIN180514 : DiGiovanna, Stern: Activation state-specific monoclonal antibody detects tyrosine phosphorylated p185neu/erbB-2 in a subset of human breast tumors overexpressing this receptor. dans Cancer research 1995 (PubMed)
    Show all 11 references for 180514

  3. Human Polyclonal HER2 Primary Antibody pour IHC (p), WB - ABIN391947 : Ehsani, Low, Wallace, Wu: Characterization of a new allele of the human ERBB2 gene by allele-specific competition hybridization. dans Genomics 1993 (PubMed)
    Show all 4 references for 391947

  4. Human Polyclonal HER2 Primary Antibody pour FACS, IF - ABIN391948 : Yamamoto, Ikawa, Akiyama, Semba, Nomura, Miyajima, Saito, Toyoshima: Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. dans Nature 1986 (PubMed)
    Show all 4 references for 391948

  5. Human Polyclonal HER2 Primary Antibody pour FACS, IHC (p) - ABIN391945 : Coussens, Yang-Feng, Liao, Chen, Gray, McGrath, Seeburg, Libermann, Schlessinger, Francke: Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. dans Science (New York, N.Y.) 1985 (PubMed)
    Show all 4 references for 391945

  6. Human Polyclonal HER2 Primary Antibody pour IF, ELISA - ABIN1532607 : King, Kraus, Aaronson: Amplification of a novel v-erbB-related gene in a human mammary carcinoma. dans Science (New York, N.Y.) 1985 (PubMed)
    Show all 3 references for 1532607

  7. Human Polyclonal HER2 Primary Antibody pour IF, ELISA - ABIN1531590 : Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. dans Cell 2006 (PubMed)
    Show all 3 references for 1531590

  8. Human Polyclonal HER2 Primary Antibody pour IHC (fro), IHC (p) - ABIN115291 : Schechter, Hung, Vaidyanathan, Weinberg, Yang-Feng, Francke, Ullrich, Coussens: The neu gene: an erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor. dans Science (New York, N.Y.) 1985 (PubMed)
    Show all 3 references for 115291

Plus d’anticorps contre HER2 partenaires d’interaction

Human V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) interaction partners

  1. Data suggest that NDRG1 (Montrer NDRG1 Anticorps) attenuates oncogenic signaling by inhibiting formation of EGFR (Montrer EGFR Anticorps)/HER2 and HER2/HER3 (Montrer ERBB3 Anticorps) heterodimers and by down-regulating EGFR (Montrer EGFR Anticorps) via a mechanism involving its degradation. (NDRG1 (Montrer NDRG1 Anticorps) = N-myc downstream regulated gene 1 protein (Montrer NDRG1 Anticorps); EGFR (Montrer EGFR Anticorps) = epidermal growth factor receptor (Montrer EGFR Anticorps); HER = human epidermal growth factor receptor (Montrer EGFR Anticorps)) [REVIEW]

  2. Elevated levels of sHER2 are associated with worse survival, irrespective of the HER2 status of the tumor, but do not provide additional prognostic information in patients with known circulating tumor cell status.

  3. Report concordance between immunohistochemistry and fluorescence I situ hybridization for HER2 on tissue microarray sections.

  4. Simultaneous suppression of ErbB (Montrer EGFR Anticorps) kinases and androgen signaling by Celecoxib represents a novel strategy to interrupt the vicious cycle of AR/ErbB (Montrer EGFR Anticorps) cross-talk with the primary purpose of undermining their resilient signaling in prostate cancer progression.

  5. An interdisciplinary group of German experts has taken on the challenges of HER2 testing in gastric cancer as an opportunity to address essential aspects and questions on the practical use of HER2 testing in this indication from the perspective of pathologists and therapists.

  6. in HER2-overexpressing D492 cells, EGFR (Montrer EGFR Anticorps) can behave as a tumor suppressor, by pushing the cells towards epithelial differentiation

  7. an important role for MUCL1 (Montrer SBEM Anticorps) in the proliferation of breast cancer cells

  8. Our study suggests that HER2 overexpression or amplification is a poor prognostic factor in lung adenocarcinoma, although the frequency of such events is low.

  9. High serum HER2 extracellular domain (ECD (Montrer SHFM1 Anticorps)) had a negative impact on overall survival in patients with gastric cancer. Serum HER2 ECD (Montrer SHFM1 Anticorps) could be a highly specific surrogate biomarker for tissue HER2 status in gastric cancer.

  10. CRISPR-mediated targeting of HER2 inhibits breast cancer cell proliferation through a dominant negative mutation.

Mouse (Murine) V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) interaction partners

  1. Combined targeting of TGF-beta (Montrer TGFB1 Anticorps), EGFR (Montrer EGFR Anticorps) and HER2 signaling suppresses lymphangiogenesis and metastasis in a pancreatic ductal adenocarcinoma model.

  2. The conjugation of benzylguanine-modified auristatin F to EGFR (Montrer EGFR Anticorps)-specific 425(scFv)-SNAP and HER2-specific alphaHER2(scFv)-SNAP resulted in two potent recombinant antibody-drug conjugates that specifically killed breast cancer cell lines by inducing apoptosis when applied at nanomolar concentrations.

  3. ErbB2 is required for neonatal cardiomyocyte proliferation. ErbB2 conditional knockout heart exhibited an upregulation of negative cell cycle regulators.

  4. Despite previous evidence suggesting that ErbB (Montrer EGFR Anticorps) receptors can bind and activate IRSs, our findings indicate that ErbB2 does not cooperate with the IRS (Montrer IARS Anticorps) pathway in mouse breast cancer model.

  5. It was suggested that transgenic HER-2/neu involves in initiation of malignization of mammary epithelial cells but also in acceleration of age-related hormonal and metabolic changes in turn promoting mammary carcinogenesis

  6. Study showed that suppression of STAT3 (Montrer STAT3 Anticorps), STAT5 (Montrer STAT5A Anticorps), and STAT6 (Montrer STAT6 Anticorps) and overexpression of the proapoptotic factor STAT1 (Montrer STAT1 Anticorps), which provides p53 (Montrer TP53 Anticorps)-mediated apoptosis, are the causes for increasing the number of apoptotic neurons in physiological aging. HER-2 tyrosine kinase receptor (Montrer KDR Anticorps) overexpression promotes neuronal survival through activation of STAT (Montrer STAT1 Anticorps)-signaling pathway with simultaneous suppression of the proapoptotic factor STAT1 (Montrer STAT1 Anticorps)

  7. that myocardial ErbB2 and beta-adrenergic receptors signalling are linked in a feedback loop with beta-adrenergic receptors activation leading to increased ErbB2 expression and activity

  8. Metformin inhibits breast tumor angiogenesis and suggest role of HIF-1alpha (Montrer HIF1A Anticorps)-VEGF (Montrer VEGFA Anticorps) signaling axis in mediating HER2-induced tumor angiogenesis.

  9. In trastuzumab-doxorubicin combination therapy in a murine model of HER2+ breast cancer.

  10. Data indicate that Sonic hedgehog (Shh (Montrer SHH Anticorps)) stimulate branching morphogenesis (BrM (Montrer SMARCA2 Anticorps)) and induced synthesis of mRNAs for Ptch1 (Montrer PTCH1 Anticorps) protein, epidermal growth factor (EGF (Montrer EGF Anticorps)) and receptors of the ErbB (Montrer EGFR Anticorps) receptors ErbB1 (Montrer EGFR Anticorps), ErbB2 and ErbB3 (Montrer ERBB3 Anticorps).

HER2 (ERBB2) profil antigène

Antigen Summary

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Alternative names and synonyms associated with HER2 (ERBB2)

  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (ERBB2) anticorps
  • v-erb-b2 avian erythroblastic leukemia viral oncogene 2 (Erbb2) anticorps
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2) anticorps
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (Erbb2) anticorps
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2) anticorps
  • c-erbB2 anticorps
  • c-neu anticorps
  • CD340 anticorps
  • Erbb-2 anticorps
  • HER-2 anticorps
  • HER-2/neu anticorps
  • HER2 anticorps
  • mKIAA3023 anticorps
  • MLN 19 anticorps
  • Neu anticorps
  • NGL anticorps
  • TKR1 anticorps

Protein level used designations for ERBB2

receptor tyrosine-protein kinase erbB-2 , Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog) , C-erbB-2 , NEU proto-oncogene , epidermal growth factor receptor-related protein , p185erbB2 , p185neu , proto-oncogene NEU , proto-oncogene c-ErbB-2 , v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog , c-erb B2/neu protein , herstatin , metastatic lymph node gene 19 protein , neuro/glioblastoma derived oncogene homolog , neuroblastoma/glioblastoma derived oncogene homolog , proto-oncogene Neu , tyrosine kinase-type cell surface receptor HER2 , Neu oncogene , avian erythroblastosis oncogene B 2 , c-erbB-2 , erbB-2

GENE ID SPECIES
426130 Gallus gallus
24337 Rattus norvegicus
2064 Homo sapiens
13866 Mus musculus
403883 Canis lupus familiaris
Fournisseurs de qualité sélectionnés pour anti-HER2 (ERBB2) Anticorps
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