Aperçu des produits pour anti-Ataxin 1 (ATXN1) Anticorps

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anti-Ataxin 1 Anticorps (ATXN1)
Chez www.anticorps-enligne.fr sont 212 Ataxin 1 (ATXN1) Anticorps de 24 de différents fournisseurs disponibles. De plus, nous expédions Ataxin 1 Kits (31) et Ataxin 1 Protéines (8) et beaucoup plus de produits pour cette protéine. Un total de 263 Ataxin 1 produits sont actuellement listés.
Synonymes:
2900016G23Rik, ataxin 1b, Atx1, atxn1, C85907, CG4547, D6S504E, dAtx-1, dAtx1, Dmel\\CG4547, ENSMUSG00000074917, Gm10786, sca1

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anti-Ataxin 1 Anticorps mieux référencés

  1. Human Monoclonal Ataxin 1 Primary Antibody pour EIA, FACS - ABIN1105458 : Krishna, Mohan, Yashavantha, Rammurthy, Kiran Kumar, Mittal, Tyagi, Mukerji, Jain, Pal, Purushottam: SCA 1, SCA 2 & SCA 3/MJD mutations in ataxia syndromes in southern India. dans The Indian journal of medical research 2007 (PubMed)
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  2. Human Polyclonal Ataxin 1 Primary Antibody pour EIA, WB - ABIN357975 : Lim, Crespo-Barreto, Jafar-Nejad, Bowman, Richman, Hill, Orr, Zoghbi: Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1. dans Nature 2008 (PubMed)
    Show all 2 references for 357975

  3. Human Polyclonal Ataxin 1 Primary Antibody pour IF, WB - ABIN389309 : Hong, Lee, Cho, Kang: UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1. dans Biochemical and biophysical research communications 2008 (PubMed)
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  4. Human Polyclonal Ataxin 1 Primary Antibody pour IF, IHC - ABIN1532502 : Mungall, Palmer, Sims, Edwards, Ashurst, Wilming, Jones, Horton, Hunt, Scott, Gilbert, Clamp, Bethel, Milne, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey, Banerjee, Barker et al.: The DNA sequence and analysis of human chromosome 6. ... dans Nature 2003 (PubMed)

Plus d’anticorps contre Ataxin 1 partenaires d’interaction

Fruit Fly (Drosophila melanogaster) Ataxin 1 (ATXN1) interaction partners

  1. Ataxin-1 induces intranuclear accumulation of dAtx2/hAtaxin-2 in both Drosophila and SCA1 postmortem neurons

  2. mutant ataxin-1 and huntingtin (Montrer HTT Anticorps) induce developmental and late-onset neuronal pathologies in Drosophila models

Human Ataxin 1 (ATXN1) interaction partners

  1. In cervical cancer cells, ATXN1 knockdown induced EMT by directly regulating Snail expression, leading to matrix metalloproteinase activation and the promotion of cell migration and invasion.

  2. ATXN1 underexpression is associated with metabolic diseases.

  3. data suggest GSK3b (Montrer GSK3b Anticorps) and mTOR (Montrer FRAP1 Anticorps) pathways modulate this ATXN1 function in spinocerebellar ataxia type-1 (SCA1)pathogenesis that could be targeted therapeutically prior to the onset of disease symptoms in SCA1 and other pathologies involving dysregulation of ATXN1 functions.

  4. SCA1 phenotypes could be reversed by partial suppression of human mutant ATXN1 mRNA by rAAV.miS1 when delivered after symptom onset in mice.

  5. SCA1 relative frequency in Poland shows the highest value compared with the data from other countries worldwide in patient with Spinocerebellar ataxias

  6. Studied Ataxin-1 using molecular modeling to investigate the protein-protein interactions contributing to the AXH domain dimer stability.

  7. Data indicate that in spinocerebellar ataxia type 1 patients the spinocerebellar ataxia type 1 protein trinucleotide repeat expansion (CAG)n was great than 39, comparing with normal 6-38.

  8. This study reports the results of molecular dynamics simulations of AXH monomer of Ataxin-1.

  9. Systematic replacement of each lysine residue in the AXH domain revealed that the lysine at 589 (K589) of ATXN1 is essential for its ubiquitylation by UbcH6 (Montrer UBE2E1 Anticorps).

  10. Results show that two SNPs in ATXN1 gene have a founder effect of the same repeat carrying allele as in the general Indian population suggesting that that Spinocerebellar ataxia type 1 disease onset is significantly delayed when transmission is maternal.

Mouse (Murine) Ataxin 1 (ATXN1) interaction partners

  1. data suggest GSK3b (Montrer GSK3b Anticorps) and mTOR (Montrer FRAP1 Anticorps) pathways modulate this ATXN1 function in spinocerebellar ataxia type-1 (SCA1)pathogenesis that could be targeted therapeutically prior to the onset of disease symptoms in SCA1 and other pathologies involving dysregulation of ATXN1 functions.

  2. Maternal diabetes induced caspase 3 (Montrer CASP3 Anticorps)-dependent apoptosis in Sca1(+) cardiac progenitor cells derived from embryonic day 17.5 (E17.5). Both maternal diabetes and high glucose in vitro activated the pro-apoptotic transcription factor, Forkhead O 3a (FoxO3a (Montrer FOXO3 Anticorps)) via dephosphorylation at threonine 32 (Thr (Montrer TRH Anticorps)-32) residue.

  3. Data establish a novel role for ATXN1 in the hippocampus as an intrinsic regulator of precursor cell proliferation, and suggest a mechanism by which polyQ expansion and loss of ATXN1 affect hippocampal function, potentially contributing to cognitive deficits and depression

  4. The results of this study found that upregulation of cholecystokinin (Cck (Montrer CCK Anticorps)) and subsequent interaction with the Cck1 (Montrer CCL28 Anticorps) receptor likely underlies the lack of progressive Purkinje cell pathology in Pcp2-ATXN1[30Q]D776 mice.

  5. Mutant ATXN1 forms oligomers whose levels correlate with disease progression in the Atxn1154Q/+ mice.

  6. The study showed that Sca1(+)Lin(-) bone marrow contains an endodermal precursor population of cells that differentiates into hepatocytes.

  7. HMGB1 (Montrer HMGB1 Anticorps) facilitates repair of mitochondrial DNA damage of mutant ataxin-1 knock-in mice.

  8. The RNA-binding protein PUMILIO1 (PUM1 (Montrer PUM1 Anticorps)) not only directly regulates ATAXIN1 but also plays an unexpectedly important role in neuronal function. Loss of Pum1 (Montrer PUM1 Anticorps) caused progressive motor dysfunction and SCA1-like neurodegeneration with motor impairment, primarily by increasing Ataxin1 levels.

  9. study found a new function of ataxin-1: the modulation of Pp2a activity and the regulation of its holoenzyme composition, with the polyglutamine mutation within Atxn1 altering this function in the spinocerebellar ataxia type 1 mouse cerebellum before disease onset

  10. Delivery of either ataxin-1-like viral vectors to Spinocerebellar Ataxia Type 1 mice cerebella resulted in widespread cerebellar Purkinje cell transduction

Ataxin 1 (ATXN1) profil antigène

Antigen Summary

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene.

Alternative names and synonyms associated with Ataxin 1 (ATXN1)

  • ataxin 1 (ATXN1) anticorps
  • ataxin 1b (atxn1b) anticorps
  • Ataxin 1 (Atx-1) anticorps
  • ataxin 1 (Atxn1) anticorps
  • ataxin 1-like (ATXN1L) anticorps
  • 2900016G23Rik anticorps
  • ataxin 1b anticorps
  • Atx1 anticorps
  • atxn1 anticorps
  • C85907 anticorps
  • CG4547 anticorps
  • D6S504E anticorps
  • dAtx-1 anticorps
  • dAtx1 anticorps
  • Dmel\\CG4547 anticorps
  • ENSMUSG00000074917 anticorps
  • Gm10786 anticorps
  • sca1 anticorps

Protein level used designations for anti-Ataxin 1 (ATXN1) Anticorps

ataxin 1 , spinocerebellar ataxia type 1 , Ataxin1 , Atx-1-PB , CG4547-PB , ataxin-1 , ataxin-1-like , spinocerebellar ataxia type 1 protein , spinocerebellar ataxia 1 homolog , spinocerebellar ataxia 1 , spinocerebellar ataxia type 1 protein homolog , spinocerebellar ataxia type 1 protien

GENE ID SPECIES
100065748 Equus caballus
493678 Felis catus
565841 Danio rerio
747421 Pan troglodytes
31624 Drosophila melanogaster
100025666 Monodelphis domestica
100402564 Callithrix jacchus
100437511 Pongo abelii
100467930 Ailuropoda melanoleuca
100588152 Nomascus leucogenys
6310 Homo sapiens
20238 Mus musculus
25049 Rattus norvegicus
488232 Canis lupus familiaris
100154571 Sus scrofa
616399 Bos taurus
100719683 Cavia porcellus
420843 Gallus gallus
101113284 Ovis aries
489725 Canis lupus familiaris
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