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anti-Mouse (Murine) Gephyrin Anticorps:
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Chicken Monoclonal Gephyrin Primary Antibody pour IF, IP - ABIN968051
Feng, Tintrup, Kirsch, Nichol, Kuhse, Betz, Sanes: Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity. dans Science (New York, N.Y.) 1998
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Chicken Monoclonal Gephyrin Primary Antibody pour IF, IP - ABIN968050
Meyer, Kirsch, Betz, Langosch: Identification of a gephyrin binding motif on the glycine receptor beta subunit. dans Neuron 1995
Show all 4 Pubmed References
Chicken Monoclonal Gephyrin Primary Antibody pour IF, IP - ABIN968898
Prior, Schmitt, Grenningloh, Pribilla, Multhaup, Beyreuther, Maulet, Werner, Langosch, Kirsch: Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein. dans Neuron 1992
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duplicated gephyrin genes mediate Moco biosynthesis and control postsynaptic clustering of glycine receptor (Montrer GLRB Anticorps)
these data reveal that IQSEC3 (Montrer IQSEC3 Anticorps) acts together with gephyrin to regulate inhibitory synapse development.
A missense mutation of gephyrin that was unable to synthesize MoCo and activate MoCo-dependent enzymes was identified.
A yin-yang haplotype pattern encompassing gephyrin consists of 284 divergent nucleotide states and both variants vary drastically from their mutual ancestral haplotype, suggesting rapid evolution.
The N-terminal region of GABRA3 (Montrer GABRA3 Anticorps) and the GlyR beta subunit (Montrer POLG Anticorps) occupies the same binding site of gephyrin.
Results show that PKC (Montrer PRRT2 Anticorps)-dependent phosphorylation of GAP43 (Montrer GAP43 Anticorps) plays a critical role in regulating postsynaptic gephyrin aggregation in developing GABAergic synapses.
Structural exonic microdeletions affecting the GPHN gene constitute a rare genetic risk factor for IGE and other neuropsychiatric disorders by an impairment of the GABAergic inhibitory synaptic transmission.
The enhancement of Cb-induced gephyrin clustering by GTP (Montrer AK3 Anticorps)-TC10 (Montrer RHOQ Anticorps) does not depend on the guanine nucleotide exchange activity of Cb but involves an interaction that resembles reported interactions of other small GTPases with their effectors
abnormal accumulations of gephyrin are highly correlated with the neuropathologic diagnosis of Alzheimer disease in 17 AD versus 14 control cases. Furthermore, gephyrin accumulations were specific for AD.
Rare exonic deletions implicate the synaptic organizer Gephyrin (GPHN) in risk for autism, schizophrenia and seizures.
Extracellular signal-regulated kinase and glycogen synthase kinase 3beta regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism
Ablation of gephyrin result in the forebrain-specific loss of postsynaptic gamma2-GABAA (Montrer GABRg1 Anticorps) receptors, reduces LTP (Montrer SCP2 Anticorps) and network excitability in the dentate gyrus.
adult mice lacking interleukin-1 receptor 1 (Montrer IL1RL1 Anticorps) (IL-1R1) exhibit increased expression of both the excitatory scaffolding protein postsynaptic density-95 (PSD-95 (Montrer DLGAP2 Anticorps)) and inhibitory scaffolding proteingephyrin, respectively, in the hippocampus.
The results demonstrate that formation of GABAergic synapses containing a postsynaptic gephyrin scaffold is crucial for morphological differentiation, synaptic integration, and long-term survival of adult-born granule cells/
Data suggest that KIF5 (Montrer KIF5A Anticorps) regulates gephyrin sorting by a mechanism that involves GSK3 (Montrer GSK3b Anticorps) activity.
Pin1 (Montrer PIN1 Anticorps)-dependent signaling represents a mechanism to modulate GABAergic transmission by regulating NL2 (Montrer MMEL1 Anticorps)/gephyrin interaction.
These results reveal a homeostatic mechanism through which activity regulates the dynamics and function of perisomatic inhibitory synapses, and they identify a CaMKII (Montrer CAMK2G Anticorps)-dependent phosphorylation site on gephyrin.
study reveals that palmitoylation of gephyrin by DHHC-12 contributes to dynamic and functional modulation of GABAergic synapses
Within this network, collybistin (Montrer Arhgef9 Anticorps) can adopt open/active and closed/inactive conformations to act as a switchable adaptor that links gephyrin to plasma membrane phosphoinositides.
these findings suggest that gephyrin may be a key factor in BDNF (Montrer BDNF Anticorps)-dependent GABAAR (Montrer GABRG2 Anticorps) regulation in the amygdala.
Data suggest that the loss of neurotransmitter receptor (Montrer GRIN1 Anticorps) clustering at inhibitory synapses causes the early lethality of gephyrin deficient mice.
This gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described\; however, the full-length nature of all transcript variants is not currently known.
, putative glycine receptor-tubulin linker protein
, LOW QUALITY PROTEIN: gephyrin