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a new AHI-1 (Montrer AHI1 Kits ELISA)-BCR-ABL (Montrer ABL1 Kits ELISA)-DNM2 protein complex was uncovered, which regulates leukemic properties of these cells through a unique mechanism of cellular endocytosis and ROS (Montrer ROS1 Kits ELISA)-mediated autophagy. Thus, targeting this complex may facilitate eradication of LSCs for curative therapies
dynamin-2, as a tetramer, might help to establish hemi-fusion and stabilizes the pore during HIV-1 fusion.
Data suggest DNM2/RRAGB (Montrer RRAGB Kits ELISA)- (or DNM2/RRAGC (Montrer RRAGC Kits ELISA)-)dependent endocytosis of extracellular amino acids (AAs (Montrer FGD1 Kits ELISA)) plays critical role in mTORC1 transport/activation; recruitment of mTORC1 from cytoplasm to lysosome is suppressed by DNM2 inhibition; AA deprivation appears to be main cause of mTORC1 inactivation via DNM2 inhibition. (RHEB (Montrer RHEB Kits ELISA) = Ras homolog enriched in brain (Montrer RHEB Kits ELISA); DNM2 = dynamin II; RRAG = Ras-related GTP binding protein (Montrer RAB10 Kits ELISA))
Study showed that dynamin 2 and cortactin participate in the formation of F-actin bundles, which stabilize filopodia in migrating cancer cells.
Data demonstrate that dynamin II is required for the E2:ERalpha (Montrer ESR1 Kits ELISA) signaling of physiological functions and uncovers a role for autophagy in the control of ERalpha (Montrer ESR1 Kits ELISA) turnover.
This study reported the clinical characteristics, molecular diagnosis strategy, and DNM2 gene mutations of four Chinese Han patients with centronuclear myopathy.
uncover a link between the dynamin 2 function and JNK (Montrer MAPK8 Kits ELISA) signaling which leads to AP-1 (Montrer FOSB Kits ELISA) induction
results provide evidence for a novel Arf6 (Montrer ARF6 Kits ELISA) activation mechanism by Dyn2 through EFA6B and EFA6D in CME in a manner dependent upon the GTPase (Montrer RACGAP1 Kits ELISA) activity of Dyn2
We conclude that DNM2 is a novel negative regulator of NO production in mouse collecting ducts.
In marked contrast to invadopodia, this degradation does not require the action of Src kinase (Montrer CSK Kits ELISA), Cdc42 (Montrer CDC42 Kits ELISA) or Dyn2. Rather, inhibition of Dyn2 causes a marked upregulation of stromal matrix degradation
Loss of Dynamin 2 GTPase (Montrer RACGAP1 Kits ELISA) function results in microcytic anaemia.
DNM2 mutations cooperate with Lmo2 (Montrer LMO2 Kits ELISA) T-cell oncogenes by enhancing IL-7 (Montrer IL7 Kits ELISA) signalling.
Genetic disruption of Dyn2 GTPase (Montrer RACGAP1 Kits ELISA) activity selectively in hepatic stellate cells enhances fibrogenesis.
Oxidative stress-induced (Montrer SQSTM1 Kits ELISA) apoptosis and reactive oxygen species production are attenuated by not only Drp1 (Montrer CRMP1 Kits ELISA) inhibition but also Dynamin 2 inhibition, implicating Dynamin 2 as a mediator of oxidative stress in cardiomyocytes.
Results show that centronuclear myopathy associated Dyn2 mutants are gain-of-function mutations, and their primary effect in muscle is T-tubule disorganization, which explains the susceptibility of muscle to Dyn2 hyperactivity.
Dynamin 2 might participate in the early embryonic development through an actin-based cytokinesis
Dynamin 2 has a role in endocytosis and in sustaining T-cell receptor signaling and driving metabolic reprogramming in T lymphocytes
DNM2-dependent endocytosis in megakaryocytes regulates megakaryopoiesis, thrombopoiesis, and bone marrow homeostasis.
Thus dynamin (Montrer DNM1 Kits ELISA) that was recently found to control late stages of myoblast fusion also controls late stages of macrophage fusion, revealing an intriguing conserved mechanistic motif shared by diverse cell-cell fusion processes.
Using an inducible knockout mouse model to generate dynamin 1 (Montrer DNM1 Kits ELISA)- and 2-deficient primary osteoclast precursors and myoblasts, it was shown that fusion of both cell types requires dynamin (Montrer DNM1 Kits ELISA).
Dynamin-2 directs actin polymerization at the exocytosis site where both, in concert, adjust the hormone quantal release.
role of the proline-rich domain of dynamin-2 in in vitro potentiation of endothelial nitric-oxide synthase (Montrer NOS3 Kits ELISA) activity.
Knocking down dynamin-2 by small interfering RNA reduced both leukotoxin internalization and cytotoxicity.
LKT-mediated cell death involve dynamin-2 and cyclophilin D
DNM2-S619L causes disease, in part, by interfering with membrane tubulation
Our findings suggest that dnm2 and dnm2-like are orthologs to human DNM2, and that they are required for normal zebrafish development.
Upregulation of miR (Montrer MYLIP Kits ELISA)-124 expression corresponded to decreased expression of its target, DNM2, in the Japanese encephalitis virus -infected PK15 cells.
Dynamin 2 possibly regulates porcine oocyte maturation through its effects on actin-mediated spindle positioning and cytokinesis, and that this may depend on regulating ARP2 (Montrer ACTR2 Kits ELISA) localization.
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined.
, dynamin 2
, dynamin II