ADAM Metallopeptidase with thrombospondin Type 1 Motif, 8 Protéines (ADAMTS8)

ADAMTS8 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. De plus, nous expédions ADAMTS8 Anticorps (63) et ADAMTS8 Kits (24) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
ADAMTS8 30806 P57110
ADAMTS8 11095 Q9UP79
Rat ADAMTS8 ADAMTS8 300475  
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Showing 5 out of 5 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,797.11
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,797.11
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$814.00
Détails
Escherichia coli (E. coli) Humain His tag 100 μg Connectez-vous pour afficher 15 to 18 Days
$672.00
Détails

ADAMTS8 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)

Human , , ,
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Plus protéines pour ADAM Metallopeptidase with thrombospondin Type 1 Motif, 8 (ADAMTS8) partenaires d'interaction

Mouse (Murine) ADAM Metallopeptidase with thrombospondin Type 1 Motif, 8 (ADAMTS8) interaction partners

  1. This study demonstrated that Cortical fast-spiking parvalbumin (Montrer PVALB Protéines) interneurons enwrapped in the perineuronal net express the metallopeptidases Adamts8 in mice.

  2. ADAMTS-4 (Montrer ADAMTS4 Protéines) expression was upregulated during the development of atherosclerosis in LDLR(-/-)ApoB(100/100) mice.

Human ADAM Metallopeptidase with thrombospondin Type 1 Motif, 8 (ADAMTS8) interaction partners

  1. This study showed that ADAMTS1 (Montrer ADAMTS1 Protéines), 8, and 18 are highly expressed in GC and its nodal metastases, suggesting important roles of these proteases in carcinogenesis and lymphatic metastasis. The findings from the present study indicate that these proteases may be promising candidates for novel and alternative treatments in GC (gastric cancer)

  2. ADAMTS8 hypermethylation is associated with decreased expression in gastric cancer.

  3. Study uncovers the tumor suppressive function of ADAMTS8 and its frequent methylation in certain tumors could be developed as a potential biomarker.

  4. ADAMTS 8, CCL23 (Montrer CCL23 Protéines), and TNFSF15 (Montrer TNFSF15 Protéines) are implicated in anti-angiogenic activities

  5. Ability of ADAMTS-8 to cleave aggrecan (Montrer ACAN Protéines) at aggrecanase (Montrer ADAMTS4 Protéines)-susceptible Glu373-Ala374 peptide bond. Presence of ADAMTS-8 mRNA transcripts in normal and osteoarthritic human cartilage. (ADAMTS-8)

  6. Downdownregulation of METH-2 expression in primary NSCLC, often associated with promoter hypermethylation, is a frequent event, which may be related to the development of the disease.

  7. ADAMTS8 and ADAMTS15 (Montrer ADAMTS15 Protéines) have emerged as novel predictors of survival in patients with breast carcinoma

  8. Immunohistochemistry and Western analysis indicated downregulation of ADAMTS-8 protein in >77% brain tumours. A role for ADAMTS-8 in brain tumorigenesis, warranting further investigation into its role in regulation of tumour angiogenesis.

  9. ADAMTS-4 (Montrer ADAMTS4 Protéines) and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of atherosclerotic plaques

Profil protéine ADAMTS8

Profil protéine

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms.

Gene names and symbols associated with ADAMTS8

  • ADAM metallopeptidase with thrombospondin type 1 motif 8 (ADAMTS8)
  • ADAM metallopeptidase with thrombospondin type 1 motif 8 (adamts8)
  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8 (Adamts8)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 8 (ADAMTS8)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 8 (Adamts8)
  • ADAM-TS8 Protéine
  • ADAMTS8 Protéine
  • METH-2 Protéine
  • METH2 Protéine

Protein level used designations for ADAMTS8

ADAM metallopeptidase with thrombospondin type 1 motif, 8 , A disintegrin and metalloproteinase with thrombospondin motifs 8 , ADAM-TS 8 , ADAM-TS8 , ADAMTS-8 precursor (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2) , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8 , ADAMTS-8 , METH-2 , METH-8 , a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8

GENE ID SPECIES
466852 Pan troglodytes
718962 Macaca mulatta
100076383 Ornithorhynchus anatinus
100387160 Callithrix jacchus
100456851 Pongo abelii
100469807 Ailuropoda melanoleuca
100497759 Xenopus (Silurana) tropicalis
100557571 Anolis carolinensis
30806 Mus musculus
11095 Homo sapiens
512544 Bos taurus
769222 Gallus gallus
100684302 Canis lupus familiaris
300475 Rattus norvegicus
101120031 Ovis aries
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