For each application a titration should be performed to determine the optimal concentration.
For Research Use only
phosphate buffered saline, pH 7.2
Conseil sur la manipulation
avoid repeated freezing and thawing
Christianson, Sun, Akilesh, Pesavento, Proetzel, Roopenian: "Monoclonal antibodies directed against human FcRn and their applications." dans: mAbs, Vol. 4, Issue 2, pp. 208-16, (2014) (PubMed).
Fc Receptor (FcRn)
The MHC class I-like Fc receptor (FcRn) is an intracellular trafficking Fc receptor that is uniquely responsible for the extended serum half-life of antibodies of the IgG subclass and their ability to transport across cellular barriers. By performing these functions, FcRn affects numerous facets of antibody biology and pathobiology. Its critical role in controlling IgG pharmacokinetics has been leveraged for the design of therapeutic antibodies and related biologics. FcRn also traffics serum albumin and is responsible for the enhanced pharmacokinetic properties of albumin-conjugated therapeutics. Synonyms: IgG receptor FcRn large subunit p51, Neonatal Fc receptor, FCGRT