Fc Receptor (FcRn) anticorps

N° du produit ABIN1774762

Détail du produit

Antigène: Fc Receptor (FcRn)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Application: Cell-ELISA (cELISA), Flow Cytometry (FACS), ELISA

Attributs du produit: based on recognition of the complete native protein expressed on transfected mammalian cells

Purification: Purified, Protein A

Immunogène: Antibodies were generated by immunizing mouse FcRn-deficient mice with spleen cells from mice transgenic for human FcRn.

Clone: ADM31

Isotype: IgG2b

Information d'application

Indications d'application:

• Flow cytometry: 1.2 μg/10^6 cells
• ELISA: 1:200 - 1:400
• CELISA: 1:200 - 1:400

For each application a titration should be performed to determine the optimal concentration.

Restrictions: For Research Use only

Stockage

Buffer: phosphate buffered saline, pH 7.2

Conseil sur la manipulation: avoid repeated freezing and thawing

Stock: 4 °C

Référence

Christianson, Sun, Akilesh, Pesavento, Proetzel, Roopenian: "Monoclonal antibodies directed against human FcRn and their applications." dans: mAbs, Vol. 4, Issue 2, pp. 208-16, 2014 (PubMed).

Détail du antigène

Antigène: Fc Receptor (FcRn)

Sujet: The MHC class I-like Fc receptor (FcRn) is an intracellular trafficking Fc receptor that is uniquely responsible for the extended serum half-life of antibodies of the IgG subclass and their ability to transport across cellular barriers. By performing these functions, FcRn affects numerous facets of antibody biology and pathobiology. Its critical role in controlling IgG pharmacokinetics has been leveraged for the design of therapeutic antibodies and related biologics. FcRn also traffics serum albumin and is responsible for the enhanced pharmacokinetic properties of albumin-conjugated therapeutics.
Synonyms: IgG receptor FcRn large subunit p51, Neonatal Fc receptor, FCGRT

UniProt: P55899