Activity-Regulated Cytoskeleton-Associated Protein Protéines (Arc)

Mouse (Murine) Activity-Regulated Cytoskeleton-Associated Protein (Arc) interaction partners

1. Specific acetylation of lysine residues on Arc (Montrer NOL3 Protéines) promote Arc (Montrer NOL3 Protéines) protein stability.

2. Stress from escapable electroshock (ES) was associated with up-regulation of brain-derived neurotrophic factor (Montrer BDNF Protéines) in amygdala as well as medial prefrontal cortex (mPFC). Stres from inescapable shock suppressed c-fos in mPFC (0 h) but induced more Arc (Montrer NOL3 Protéines) in amygdala (2 h) in comparison with ES.

3. Our data support the hypothesis that the kinetics of Arc (Montrer NOL3 Protéines) induction to refine cortical representations of sensory categories is sensitive to the familiarity of the sensory experience.

4. PSD95 (Montrer DLG4 Protéines) was essential for Arc (Montrer NOL3 Protéines) assembly into 1.5-MDa complexes and activity-dependent recruitment to excitatory synapses.

5. Data show that although activity-dependent expression of activity regulated cytoskeletal-associated protein (Arc) mRNA does not change with age, expression of Arc (Montrer NOL3 Protéines) protein is maximal during the critical period and declines in adulthood.

6. It appears that palmitoylation regulates at least a subset of Arc (Montrer NOL3 Protéines) functions in synaptic plasticity.

7. These results indicate that dopamine is required to drive activity-dependent amplification of Arc (Montrer NOL3 Protéines) mRNA in the developing postnatal frontal cortex.

8. Study demonstrates in mice that explored novel spatial environments, the involvement of Egr3 (Montrer EGR3 Protéines) in regulating the late protein-dependent phase of Arc (Montrer NOL3 Protéines) expression in the dentate gyrus.

9. Arc/Arg3.1 effects on memory formation are not only manifested at the level of molecular pathways regulating synaptic plasticity, but also at the systems level.

10. CTCF (Montrer CTCF Protéines) knockdown attenuates fear-conditioning-induced hippocampal gene expression of key learning genes and loss of long-range interactions at the BDNF (Montrer BDNF Protéines) and Arc (Montrer NOL3 Protéines) loci.

Human Activity-Regulated Cytoskeleton-Associated Protein (Arc) interaction partners

1. The ARC (Montrer NOL3 Protéines) complex revealed association with verbal and total IQ in child.

2. Study identified several rare mutations that reduced ARC (Montrer NOL3 Protéines) expression in schizophrenia patients. Furthermore, DNA methylation (Montrer HELLS Protéines) of ARC (Montrer NOL3 Protéines) in schizophrenia patients may be associated with a downregulation of ARC (Montrer NOL3 Protéines) mRNA expression. These findings suggest that multiple rare ARC (Montrer NOL3 Protéines) variants and DNA methylation (Montrer HELLS Protéines) of ARC (Montrer NOL3 Protéines) might contribute to the pathogenesis of schizophrenia.

3. missense mutations in TRIAD3 abolished the interaction of TRIAD3A with Arc (Montrer NOL3 Protéines), disrupting Arc (Montrer NOL3 Protéines) ubiquitination, and consequently Arc (Montrer NOL3 Protéines) degradation.

4. ARC (Montrer NOL3 Protéines) confers resistance to sunitinib in renal cell carcinoma (Montrer MOK Protéines) through alternate angiogenesis pathways

5. We tested whether ARC (Montrer NOL3 Protéines) variants are associated with six measures of cognitive functioning in 670 healthy subjects in the Norwegian Cognitive NeuroGenetics (NCNG) by extracting data from its Genome-Wide Association Study (GWAS).

6. this is the first report associating an ARC (Montrer NOL3 Protéines) SNP with schizophrenia and supports recent large-scale GWAS findings implicating the ARC (Montrer NOL3 Protéines) complex in schizophrenia risk

7. we propose that the peculiar characteristics of Arc (Montrer NOL3 Protéines) protein, such as its optimal expression after ongoing experience or familiar behavior could explain how familiarization and recognition memories are stored and preserved in the mammalian brain--{REVIEW}

8. mRNA levels of ARC (Montrer NOL3 Protéines) and SGK1 (Montrer SGK1 Protéines) did not differ significantly between the schizophrenia or control samples.

9. Arc (Montrer NOL3 Protéines) is a flexible multi-domain protein that exists in monomeric and oligomeric forms, compatible with a diverse, hub-like role in plasticity-related processes.

10. Degradation of Arc (Montrer NOL3 Protéines) by clathrin-localized Triad3A regulates the availability of synaptic AMPA (Montrer GRIA3 Protéines) receptors.