Activity-Regulated Cytoskeleton-Associated Protein Protéines (Arc)

Plays a role in the regulation of cell morphology and cytoskeletal organization. De plus, nous expédions Arc Anticorps (44) et Arc Kits (14) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
Arc 11838 Q9WV31
Arc 23237 Q7LC44
Arc 54323 Q63053
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Showing 7 out of 8 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher 11 Days
Escherichia coli (E. coli) Souris His tag   50 μg Connectez-vous pour afficher 13 to 16 Days
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
Levure Poulet His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
Escherichia coli (E. coli) Souris Inconjugué   100 μg Connectez-vous pour afficher 11 to 18 Days
Escherichia coli (E. coli) Humain Inconjugué 100 μg Connectez-vous pour afficher 13 to 16 Days
Escherichia coli (E. coli) Rat Inconjugué   100 μg Connectez-vous pour afficher 11 to 18 Days

Arc Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)

Human ,

Rat (Rattus) ,

Plus protéines pour Activity-Regulated Cytoskeleton-Associated Protein (Arc) partenaires d'interaction

Mouse (Murine) Activity-Regulated Cytoskeleton-Associated Protein (Arc) interaction partners

  1. These data indicate that suppression of CHOP by endogenous levels of ARC is critical for beta-cell viability and maintenance of normal islet structure in this model of type 2 diabetes.

  2. Arc expression increased in the amygdala and prefrontal cortex following conditioned stimulus presentation.

  3. These results demonstrate that Arc/Arg3.1 mediates a critical period for spatial learning, during which Arc/Arg3.1 fosters maturation of hippocampal network activity necessary for future learning and memory storage.

  4. Arc extracellular vesicles mediate intercellular transfer of Arc mRNA in neurons.

  5. Specific acetylation of lysine residues on Arc promote Arc protein stability.

  6. Stress from escapable electroshock (ES) was associated with up-regulation of brain-derived neurotrophic factor in amygdala as well as medial prefrontal cortex (mPFC). Stres from inescapable shock suppressed c-fos in mPFC (0 h) but induced more Arc in amygdala (2 h) in comparison with ES.

  7. Our data support the hypothesis that the kinetics of Arc induction to refine cortical representations of sensory categories is sensitive to the familiarity of the sensory experience.

  8. PSD95 was essential for Arc assembly into 1.5-MDa complexes and activity-dependent recruitment to excitatory synapses.

  9. Data show that although activity-dependent expression of activity regulated cytoskeletal-associated protein (Arc) mRNA does not change with age, expression of Arc protein is maximal during the critical period and declines in adulthood.

  10. It appears that palmitoylation regulates at least a subset of Arc functions in synaptic plasticity.

  11. These results indicate that dopamine is required to drive activity-dependent amplification of Arc mRNA in the developing postnatal frontal cortex.

  12. Study demonstrates in mice that explored novel spatial environments, the involvement of Egr3 in regulating the late protein-dependent phase of Arc expression in the dentate gyrus.

  13. Arc/Arg3.1 effects on memory formation are not only manifested at the level of molecular pathways regulating synaptic plasticity, but also at the systems level.

  14. CTCF knockdown attenuates fear-conditioning-induced hippocampal gene expression of key learning genes and loss of long-range interactions at the BDNF and Arc loci.

  15. Genetic disruption of Arc in mice causes alterations in dopamine and neurobehavioral phenotypes related to schizophrenia.

  16. Data indicate that ARC overexpression diminishes amyloid-induced JNK pathway activation and apoptosis in the beta-cell, a strategy that may reduce beta-cell loss in type 2 diabetes

  17. Activity-regulated cytoskeleton-associated protein accumulates in the nucleus in response to cocaine and acts as a brake on chromatin remodeling and long-term behavioral alterations.

  18. This is a promising novel therapeutic approach because it appears to be effective in a model producing severe injury by interfering with an array of proximal signals and effectors of the ischemic cascade, upstream of JNK, caspases, and BIM and BAX activation.

  19. missense mutations in TRIAD3 abolished the interaction of TRIAD3A with Arc, disrupting Arc ubiquitination, and consequently Arc degradation.

  20. The dynamics of the c-Fos and Arc expression has a biphasic pattern: the first peak was observed in 15-30 min after learning and the second less pronounced peak in 1-3 h.

Human Activity-Regulated Cytoskeleton-Associated Protein (Arc) interaction partners

  1. Our results indicated that the Arc gene would confer susceptibility to Alzheimer disease in Han Chinese, probably through changing the protein structure or affecting the Arc expression in brain tissues, which would finally contribute to the pathogenesis and development of AD.

  2. The ARC complex revealed association with verbal and total IQ in child.

  3. Study identified several rare mutations that reduced ARC expression in schizophrenia patients. Furthermore, DNA methylation of ARC in schizophrenia patients may be associated with a downregulation of ARC mRNA expression. These findings suggest that multiple rare ARC variants and DNA methylation of ARC might contribute to the pathogenesis of schizophrenia.

  4. missense mutations in TRIAD3 abolished the interaction of TRIAD3A with Arc, disrupting Arc ubiquitination, and consequently Arc degradation.

  5. ARC confers resistance to sunitinib in renal cell carcinoma through alternate angiogenesis pathways

  6. We tested whether ARC variants are associated with six measures of cognitive functioning in 670 healthy subjects in the Norwegian Cognitive NeuroGenetics (NCNG) by extracting data from its Genome-Wide Association Study (GWAS).

  7. this is the first report associating an ARC SNP with schizophrenia and supports recent large-scale GWAS findings implicating the ARC complex in schizophrenia risk

  8. we propose that the peculiar characteristics of Arc protein, such as its optimal expression after ongoing experience or familiar behavior could explain how familiarization and recognition memories are stored and preserved in the mammalian brain--{REVIEW}

  9. mRNA levels of ARC and SGK1 did not differ significantly between the schizophrenia or control samples.

  10. Arc is a flexible multi-domain protein that exists in monomeric and oligomeric forms, compatible with a diverse, hub-like role in plasticity-related processes.

  11. Degradation of Arc by clathrin-localized Triad3A regulates the availability of synaptic AMPA receptors.

  12. we report a novel ARC single nucleotide polymorphism associated with a reduced risk of developing Alzheimer disease.

  13. analysis of dynamic, multifaceted control of Arc synthesis during mAchR signaling

  14. Strong fibrinogen and Abeta deposition is demonstrated in small- and medium-sized vessels, but not in large cerebral arteries, of 24-month-old transgenic arcAbeta mice.

  15. Arc Expression Is Increased in medial frontal cortex of patients with Alzheimer's Disease.

  16. Arc/MS2 mRNA assembles into particles that move independently, bidirectionally, and intermittently. These observations identify several phases of Arc mRNA movement that serve as potential points for regulating Arc mRNA localization.

Profil protéine Arc

Profil protéine

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration (By similarity). Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors.

Gene names and symbols associated with Arc

  • activity regulated cytoskeleton associated protein (ARC)
  • activity-regulated cytoskeleton-associated protein (arc)
  • activity regulated cytoskeletal-associated protein (Arc)
  • activity-regulated cytoskeleton-associated protein (Arc)
  • ARC Protéine
  • Arc3.1 Protéine
  • ARG3.1 Protéine
  • C86064 Protéine
  • mArc Protéine
  • rg3.1 Protéine

Protein level used designations for Arc

activity-regulated cytoskeleton-associated protein , activity-regulated cytoskeleton-associated-like protein , ARC/ARG3.1 , activity-regulated gene 3.1 protein homolog , activity regulated cytoskeletal-associated protein , activity-regulated gene 3.1 protein , arg3.1

472874 Pan troglodytes
519403 Bos taurus
752001 Taeniopygia guttata
100271754 Xenopus (Silurana) tropicalis
11838 Mus musculus
23237 Homo sapiens
54323 Rattus norvegicus
395075 Gallus gallus
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