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May be a Rab21 guanine exchange factor and regulate endosome dynamics.. De plus, nous expédions ANKRD27 Anticorps (23) et beaucoup plus de produits pour cette protéine.
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VARP regulates endosomal trafficking and and retromer-mediated endosome-to-plasma membrane sorting of transmembrane proteins by binding to rab GTP-Binding Proteins and R-SNARE VAMP7 [review].
Eosinophilic esophagitis was associate with increased expression of ANKRD27.
VAMP7-SNARE motif is trapped between Varp and the VAMP7 longin domain, and hence Varp kinetically inhibits the ability of VAMP7 to form SNARE complexes
Varp physically interacts with Rab38, and preferentially binds to the active GTP-bound form of Rab38 both in vitro and in vivo.
show that TI-VAMP interacts with the Vps9 domain and ankyrin-repeat-containing protein Varp, a guanine nucleotide exchange factor of the small GTPase Rab21, through a specific domain herein called the interacting domain.
RACK1 competes with Rab40C for binding to the ANKR2 domain of Varp and regulates dendrite outgrowth through stabilization of Varp in mouse melanocytes
both the Rab32/38 binding activity and VAMP7 binding activity of Varp are essential for trafficking of Tyrp1 in melanocytes but activation of Rab21 by the VPS9 domain is not necessary for Tyrp1 trafficking
Varp is a potential Rab21 guanine nucleotide exchange factor and might regulate endosome dynamics in vivo
Varp functions as the Rab32/38 effector that controls trafficking of Tyrp1 in melanocytes.
May be a Rab21 guanine exchange factor and regulate endosome dynamics.
VPS9 domain-containing protein
, VPS9-ankyrin-repeat protein
, Vps9 domain and ankyrin-repeat-containing protein
, ankyrin repeat domain-containing protein 27
, VPS9-ankyrin repeat-containing protein
, mFLJ00040 protein