Anoctamin 6 (ANO6) Kits ELISA

ANO6 encodes a multi-pass transmembrane protein that belongs to the anoctamin family. De plus, nous expédions Anoctamin 6 Anticorps (32) et Anoctamin 6 Protéines (6) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
Anti-Souris ANO6 ANO6 105722 Q6P9J9
Anti-Rat ANO6 ANO6 315272  
ANO6 196527 Q4KMQ2
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Humain 0.127 ng/mL 0.31 ng/mL - 20 ng/mL 96 Tests 13 to 16 Days
$736.84
Détails

Plus Kits ELISA pour Anoctamin 6 partenaires d'interaction

Mouse (Murine) Anoctamin 6 (ANO6) interaction partners

  1. Study identified an inner activation gate, which is established by three hydrophobic residues, F518, Y563 and I612, in the middle of the phospholipid permeation pathway of TMEM16F-CaPLSase. Disrupting the inner gate profoundly alters TMEM16F phospholipid permeation.

  2. TMEM16F knockout did not affect Ca2+ signaling and Ca2+-activated whole cell currents in podocytes. TMEM16F shows little effect on basal properties of podocytes and does not appear to be essential for renal function.

  3. TMEM16F interaction with phosphatidylinositol-(4, 5)-bisphosphate works synergistically with membrane depolarization to facilitate Ca(2+)-gating of TMEM16F.

  4. TMEM16F is an essential component of the microglial response to injury and suggest the importance of microglial phagocytosis in the pathogenesis of neuropathic pain.

  5. The present data demonstrate the activation of ANO6 during necroptosis, which, however, is not essential for cell death.

  6. TMEM16F deficiency results in sustained signaling and augmented T cell activation.

  7. Platelet TMEM16F activity contributes significantly to hemostasis and thrombosis but not cerebral thromboinflammation.

  8. ANO6 produces volume-regulated anion currents and controls cell volume in four unrelated cell types.

  9. deficiency in Ano6 resulted in reduced viability with increased bleeding time

  10. Although broadly expressed, Ano6 has no role in intestinal cholinergic Cl- secretion.

  11. Ano6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages.

  12. TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets.

  13. Ano6 and Ano2 proteins co-localize in the ciliary membrane microdomains, which indicates a role for Ano6 in olfactory signaling.

  14. human osteoblasts and osteoblasts from Ano6(-/-) and WT mice, we demonstrate that NCX1 requires Ano6 to efficiently translocate Ca(2+) out of osteoblasts into the calcifying bone matrix

  15. Ano6 plays an essential role in C2C12 myoblast proliferation

  16. findings show TMEM16A and TMEM16F have an important function in cell migration-TMEM16A in directional migration, TMEM16F in determination of speed of migration; conclude that TMEM16A and TMEM16F channels have a distinct impact on steering and motor mechanisms of migrating ELA cells

  17. TMEM16A and -16F use a similar mechanism for sorting to plasma membrane and protein stabilization, but their functional domains significantly differ

  18. The mTMEM16F-associated ICl,Ca was abolished in one mutant of the putative pore region (R592E.

  19. In primary Ano6(-/-) osteoblasts, mineralization is delayed, indicating a cell autonomous function of Ano6.

  20. TMEM16F forms a SCAN channel with considerable Ca2+ selectivity-an unprecedented finding of a cation channel as a closely related family member of anion channels; loss of TMEM16F function greatly reduced the propensity to thrombosis.

Human Anoctamin 6 (ANO6) interaction partners

  1. GD-N induced cell death in HEK293 and HAP1 cells was depending on expression of endogenous TMEM16F.

  2. Study identified an inner activation gate, which is established by three hydrophobic residues, F518, Y563 and I612, in the middle of the phospholipid permeation pathway of TMEM16F-CaPLSase. Disrupting the inner gate profoundly alters TMEM16F phospholipid permeation.

  3. We conclude that ANO6, by virtue of its scramblase activity, may play a role as an important regulator of the ADAM-network in the plasma membrane.

  4. Both inactivating and activating mutants that elucidate the mechanism for TMEM16F activation.

  5. ANO6 current shows sluggish activation even with high [Ca2+]i, and inactivation. Actin cytoskeleton disruption accelerate both activation and inactivation of ANO6. Intracellular MgATP further delays ANO6 activation, and prevent inactivation.

  6. The authorsreport the first association in two sisters of a deletion and a nonsense variation explaining the pathophysiology of Scott syndrome.

  7. ICl,Swell, and cell volume are regulated by Ano6. The findings suggest a novel clinically-relevant approach for altering cell volume, and thereby outflow resistance, by targeting Ano6.

  8. TMEM16F modifies viability of Human Embryonic Kidney cells via its function as a phospholipid scramblase and activation of AKT signaling pathways.

  9. Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms

  10. deficiency in Ano6 resulted in reduced viability with increased bleeding time

  11. ANO6 is highly expressed in apoptotic cyst epithelial cells of human polycystic kidneys.

  12. facilitates transbilayer migration of lipids [review]

  13. Homology modeling shows that the scramblase domain forms an unusual hydrophilic cleft that faces the lipid bilayer and may function to facilitate translocation of phospholipid between membrane leaflets.

  14. Ano6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages.

  15. using human osteoblasts and osteoblasts from Ano6(-/-) and WT mice, we demonstrate that NCX1 requires Ano6 to efficiently translocate Ca(2+) out of osteoblasts into the calcifying bone matrix

  16. TMEM16A and -16F use a similar mechanism for sorting to plasma membrane and protein stabilization, but their functional domains significantly differ

  17. Anoo6 induces a chloride ion conductance along with a smaller nonselective cation conductance that is activated either calcium ion dependently (ionomycin) or calcium independently(fas receptor), but not during mitochondrial apoptosis.

  18. a significant association between rs17095830 and inflammatory bowel disease was observed in a Taiwanese population

  19. TMEM16F is an essential component of a divalent calcium ion-activated Cl- channel with a divalent calcium ion sensitivity that is distinct from that of TMEM16A/B and not related to volume-sensitive outwardly rectifying Cl- channel (VSOR) activity.

  20. It scrambles phospholipids in cell membrane and its mutation leads to Scott syndrome. (review)

Anoctamin 6 (ANO6) profil antigène

Antigen Summary

This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Anoctamin 6 (ANO6) Kits ELISA

  • anoctamin 6 (ANO6) anticorps
  • anoctamin 6 (ano6) anticorps
  • anoctamin 6 (Ano6) anticorps
  • 2900059G15Rik anticorps
  • AA407480 anticorps
  • AW554778 anticorps
  • BDPLT7 anticorps
  • F730003B03Rik anticorps
  • SCTS anticorps
  • Tmem16f anticorps

Protein level used designations for Anoctamin 6 (ANO6) Kits ELISA

anoctamin 6 , transmembrane protein 16F , abnormal X segregation-like , Transmembrane protein 16F , anoctamin-6-like , SCAN channel , anoctamin-6 , small-conductance calcium-activated nonselective cation channel

GENE ID SPECIES
451845 Pan troglodytes
486597 Canis lupus familiaris
521784 Bos taurus
701540 Macaca mulatta
100084251 Ornithorhynchus anatinus
100155593 Sus scrofa
100227071 Taeniopygia guttata
100337802 Oryctolagus cuniculus
100449080 Pongo abelii
100467950 Ailuropoda melanoleuca
100486935 Xenopus (Silurana) tropicalis
100555469 Anolis carolinensis
100599841 Nomascus leucogenys
105722 Mus musculus
315272 Rattus norvegicus
196527 Homo sapiens
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