Atonal Homolog 1 (Drosophila) (ATOH1) Kits ELISA

This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. De plus, nous expédions ATOH1 Anticorps (133) et ATOH1 Protéines (9) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
ATOH1 474 Q92858
ATOH1 11921 P48985
Anti-Rat ATOH1 ATOH1 500156  
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
Humain 0.469 ng/mL 0.78 ng/mL - 50 ng/mL A typical standard curve 96 Tests 13 to 16 Days
  96 Tests 15 to 18 Days

Plus Kits ELISA pour ATOH1 partenaires d'interaction

Zebrafish Atonal Homolog 1 (Drosophila) (ATOH1) interaction partners

  1. A genetic network of sensory determinant, Atoh1 (and Sox9a), play critical roles in otic neural development.

  2. Sox2 and Fgf interact with Atoh1 to promote sensory competence throughout the zebrafish inner ear.

  3. Atoh1a expression must be restricted by Notch signaling for effective morphogenesis of the posterior lateral line primordium in zebrafish.

  4. in the zebrafish, two proneural genes are essential for differentiation of the hair cells, neuroD and atonal homolog 1

  5. atoh1a and atoh1b are together necessary for hair cell development. These genes crossregulate each other but are differentially required during distinct developmental periods

  6. atoh1.2 and beta3.1 are transcribed in distinct precursors.

Human Atonal Homolog 1 (Drosophila) (ATOH1) interaction partners

  1. Atoh1 promotes ciliogenesis by transcriptionally regulating Cep131, which facilitates centriolar satellite clustering to the basal body

  2. ATOH1 role in colon cancer.Positive ATOH1 expression in colon cancer tissues was significantly associated with lower grade and better overall survival.ATOH1 was the target mRNA of miR-613.

  3. Data indicate that transcription factor atonal bHLH transcription factor 1 protein (Atoh1) is critical for hair cell development and regeneration [Review].

  4. Our results suggest that KN promotes goblet cell differentiation by regulating Wnt, Notch, and AhR signals and expression of Hes1 and Hath1.

  5. The authors discovered tyrosine 78 of Atoh1 is phosphorylated by a Jak2-mediated pathway only in tumor-initiating cells and in human Sonic Hedgehog-type medulloblastoma.

  6. ATOH1 expression was detected consistently in recurrent and metastatic SHH medulloblastoma. Chromatin immunoprecipitation sequencing and gene expression profiling identified candidate ATOH1 targets in tumor cells involved in development and tumorigenesis.

  7. These data indicate that the regulation of Atoh1 by the ubiquitin proteasome pathway is necessary for hair cell fate determination and survival.

  8. ATOH1 is increased in advanced Merkel cell carcinoma (MCC) indicating that ATOH1 is involved in MCC progression.

  9. Study provides evidence that Sox2 expression is required for the late stages of progenitor cell differentiation to hair cells and stimulates Atoh1 expression through a concentration dependent molecular interaction with the 3' enhancer of Atoh1.

  10. mutation not found in group of children with sensorineural hearing loss

  11. Downregulation of Hath1 expression promoted the proliferation and reduced the apoptosis of KUMA5 squamous cell carcinoma cells.

  12. ATOH1 can induce the differentiation of gastric cancer stem cells.

  13. ATOH1 acts in concert with other transcription factors to directly regulate the cochlear hair cell phenotype.

  14. Testosterone-bovine serum albumin and Math1 treatment could promote an increase in hair-cell like cells in the lesser epithelial ridge through proliferation and transdifferentiation.

  15. Atoh1 epigenetic regulation guides hair cell development in the mammalian cochlea

  16. Atoh1 protein stabilization induced both a cancer stem cell phenotype and a mucinous phenotype, resulting in the acquisition of chemoresistance in colorectal cancer

  17. Chicken Atoh1 might have intrinsic functional differences to mammalian Atoh1.

  18. In this review, expression of the Atoh1 gene in supporting cells, results in their transformation into immature hair cells.

  19. Data suggest that Atoh1 high expression correlates with a good prognosis and it may serve as a favorable prognostic factor for GIST.

  20. Expression of Hath1, Muc2, cyclin D1 and p27 in the xenograft tumors was also detected.

Mouse (Murine) Atonal Homolog 1 (Drosophila) (ATOH1) interaction partners

  1. Atoh1 (+) cells contributed minimally to other lineages during homeostasis, they displayed plasticity and contributed to epithelial repair during injury, independent of Lgr5 (+) cells

  2. Progenitor plasticity maintains robust self-renewal in the intestinal epithelium, and the balance between stem and progenitor fate is directly coordinated by ATOH1 multisite phosphorylation.

  3. Meis1 regulates degradation of Atoh1 via bone morphogenic protein signaling, contributing to granule cells differentiation in the inner external granule

  4. Atoh1 thus promotes the development of the neural circuits governing hypoxic and hypercapnic chemoresponses.

  5. Study identified 51 key reprogramming transcription factors that may increase the efficiency and completion of the regeneration process and confirmed that Isl1 in transgenic mice promotes Atoh1-mediated sensory regeneration as a co-reprogramming factor.

  6. Sox4 promoted tuft and enteroendocrine cell lineage allocation independently of Atoh1. These results challenge the longstanding model in which Atoh1 is the sole regulator of secretory differentiation in the intestine and are relevant for understanding epithelial responses to parasitic infection.

  7. The results of this study presented here from various Atoh1 mutants demonstrate that neither peripheral nor central target cell differentiation is necessary for cochlear afferent segregation from vestibular afferents or for some degree of a cochleotopic segregation

  8. Atoh1 function in hair cell differentiation is modulated by interaction with other transcription factors, such as Gfi1 and Pou4f3. (Review)

  9. The data suggest that ErbB3 restricts Paneth cells numbers through PI3K-mediated suppression of Atoh1 levels leading to inhibition of Paneth cells differentiation, with important implications for regulation of the intestinal stem cells niche.

  10. This study illustrates a SHH-Stox1-Math1 regulatory axis in normal cerebellar development and medulloblastoma formation.

  11. This work reveals a dynamic ATOH1-driven molecular cascade underlying medulloblastoma metastasis that offers possible therapeutic opportunities

  12. The discovery that Atonal homolog 1 (Atoh1) governs the development of the sensory hair cells in the inner ear led to therapeutic efforts to restore these cells in cases of human deafness.

  13. miR-183 family expression in combination with Atoh1 not only appears to fine tune gene expression in favor of hair cells fate, but is also required for the expression of some hair cell-specific genes.

  14. These data illuminate a genetic pathway that initiates auditory HC regeneration and suggest p27(Kip1), GATA3, and POU4F3 as additional therapeutic targets for ATOH1-mediated auditory hair cells regeneration.

  15. Study provides evidence that Sox2 expression is required for the late stages of progenitor cell differentiation to hair cells and stimulates Atoh1 expression through a concentration dependent molecular interaction with the 3' enhancer of Atoh1.

  16. Hes/Hey signaling at the Atoh1 promoter has a role in selection of cell fate in the organ of Corti

  17. The retrotrapezoid nucleus neurons expressing Atoh1 and Phox2b are essential for the respiratory response to CO2.

  18. propose Atoh1 neurons tune the sequential activation of independent oscillators essential for the fine control of different muscles during breathing

  19. our data indicate that beta-catenin and Atoh1 mediate synergistic effects on both proliferation and differentiation of a subset of neonatal cochlear Lgr5+ cells

  20. Atoh1 expression is sufficient to produce new Merkel cells in the epidermis

ATOH1 profil antigène

Antigen Summary

This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47.

Gene names and symbols associated with ATOH1

  • atonal bHLH transcription factor 1a (atoh1a) anticorps
  • atonal homolog 1 (Drosophila) (ATOH1) anticorps
  • atonal bHLH transcription factor 1b (atoh1b) anticorps
  • absent MD neurons and olfactory sensilla (LOC663144) anticorps
  • atonal bHLH transcription factor 1 (ATOH1) anticorps
  • atonal bHLH transcription factor 1 (Atoh1) anticorps
  • ATH1 anticorps
  • ATOH1 anticorps
  • Atoh1.1 anticorps
  • Atoh1.2 anticorps
  • bHLHa14 anticorps
  • CATH1 anticorps
  • Hath1 anticorps
  • MATH-1 anticorps
  • Math1 anticorps
  • RGD1565171 anticorps
  • Tath1 anticorps
  • ZATH-1 anticorps
  • zath1 anticorps
  • zgc:136417 anticorps

Protein level used designations for ATOH1

Zath1a , protein atonal homolog 1 , atonal homolog 1 (Drosophila) , Zath1b , absent MD neurons and olfactory sensilla , GLEAN_03170 , atonal homolog 1 , class A basic helix-loop-helix protein 14 , helix-loop-helix protein hATH-1 , helix-loop-helix protein mATH-1 , atonal 1

30303 Danio rerio
428742 Gallus gallus
493915 Danio rerio
663144 Tribolium castaneum
704893 Macaca mulatta
100354967 Oryctolagus cuniculus
474 Homo sapiens
11921 Mus musculus
500156 Rattus norvegicus
487864 Canis lupus familiaris
539158 Bos taurus
461380 Pan troglodytes
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