anti-BMP Binding Endothelial Regulator (BMPER) Anticorps

Fruit Fly (Drosophila melanogaster) BMP Binding Endothelial Regulator (BMPER) interaction partners

1. The bone morphogenetic protein- binding protein Cv-2 negatively regulates bone morphogenetic protein signaling.

2. Cv-2 is a short-range, concentration-dependent, biphasic modulator of BMP signaling.

Zebrafish BMP Binding Endothelial Regulator (BMPER) interaction partners

1. The NMR structure of the Danio rerio CV2 VWC1 (Montrer VWCE Anticorps) domain in its unbound state shows the key features for high affinity binding to BMP-2 (Montrer BMP4 Anticorps) are a pre-oriented peptide loop.

2. Crossveinless 2 functions in a positive-feedback loop to locally enhance BMP activity and is required for neural crest fate determination.

3. LRP1 (Montrer LRP1 Anticorps) acts as an endocytic receptor for Bmper and a coreceptor of Bmp4 (Montrer BMP4 Anticorps) to mediate the endocytosis of the Bmper/Bmp4 (Montrer BMP4 Anticorps) signaling complex.

4. Binding of CV2 to Chordin (Montrer CHRD Anticorps) promotes BMP-2 (Montrer BMP4 Anticorps) signaling.

5. Cvl2 was identified as an essential pro-bone morphogenetic protein factor during zebrafish embryogenesis.

6. Bmper is a conserved regulator of hematopoietic and vascular development in zebrafish.

7. Initial crystallographic analysis suggests that a complete binary complex consisting of one BMP2 (Montrer BMP4 Anticorps) dimer bound to two crossveinless 2 (CV2) von Willebrand type C (VWC1 (Montrer VWCE Anticorps)) domains is present in the asymmetric unit.

8. The structure of the complex between CV-2 Von Willebrand factor (Montrer VWF Anticorps) type C (VWC) domain 1 and BMP-2 (Montrer BMP4 Anticorps), is reported.

Xenopus laevis BMP Binding Endothelial Regulator (BMPER) interaction partners

1. CV2/Chordin interaction may help coordinate bone morphogenetic protein (BMP) diffusion to the ventral side of the embryo, ensuring that BMPs liberated from Chordin inhibition by tolloid proteolysis cause peak signaling levels.

Human BMP Binding Endothelial Regulator (BMPER) interaction partners

1. Overexpression of BMPER remarkably enhanced BMP-2 (Montrer BMP2 Anticorps)-induced osteogenic differentiation, while suppression of BMPER effectively inhibited this process both in vitro and in vivo.

2. that BMPER-modulated BMP pathway activity regulates VE-cadherin (Montrer CDH5 Anticorps) expression and vascular barrier function

3. BMPER variants associated with a novel, attenuated subtype of diaphanospondylodysostosis.

4. BMPER-dependent pathway involved in high glucose induced alkaline phosphatase expression in vascular smooth muscle cells.

5. The proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 (Montrer THBS1 Anticorps) and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis.

6. these results suggest that BMPER and Tsg maintain a fine-tuned equilibrium that controls BMP pathway activity and is necessary for vascular cell homeostasis.

7. BMPER is a novel regulator of the osteoblast-like differentiation of HCASMCs.

8. Bmper is a critical regulator of Bmp-mediated vascular inflammation and that the fine-tuning of Bmp and Bmper levels is essential in the maintenance of normal vascular homeostasis.

9. The data unequivocally demonstrated that BMPER is highly expressed in malignant tumors and that the growth of lung, colon, and uterine carcinomas is dependent on the presence of BMPER.

10. Mutual regulation by BMP-9 (Montrer GDF2 Anticorps) and CV2 is essential in regulating the development of the vascular endothelium.

Cow (Bovine) BMP Binding Endothelial Regulator (BMPER) interaction partners

1. Results identified variant SNPs in BMPER gene associated with phenotypic variation in cattle that can be used as genetic markers for breeding.

Pig (Porcine) BMP Binding Endothelial Regulator (BMPER) interaction partners

1. BMPER promoter polymorphisms have an effect on the intramuscular fat deposition in longissimus dorsi muscle content.

Mouse (Murine) BMP Binding Endothelial Regulator (BMPER) interaction partners

1. BMPER contributes to the precise control of BMP activity within the aorta-gonad-mesonephros region, enabling the maturation of hematopoietic stem cells within a BMP-negative environment.

2. CV2 binds directly to BMP10 (Montrer BMP10 Anticorps), as determined by co-immunoprecipitation, and inhibits BMP10 (Montrer BMP10 Anticorps) from initiating SMAD (Montrer SMAD1 Anticorps) signaling, as determined by luciferase reporter gene assays. BMP10 (Montrer BMP10 Anticorps) and CV2 have important roles in coordinating cardiomyogenesis in progenitor cells.

3. BMPER/low-density lipoprotein receptor-related protein 1 (Montrer LRP1 Anticorps) axis plays a pivotal role in pulmonary inflammatory response.

4. The proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 (Montrer THBS1 Anticorps) and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis.

5. BMPER-induced BMP signaling promotes coronary artery remodeling.

6. BMPER appears to play a role in regulating both vessel density and cardiac development

7. BMPER expression is decreased following lung injury, which in turn impairs epithelial integrity, characterized by reduction of E-cadherin (Montrer CDH1 Anticorps) and epithelial leakage in vitro and in vivo.

8. Bmper is a critical regulator of Bmp-mediated vascular inflammation and that the fine-tuning of Bmp and Bmper levels is essential in the maintenance of normal vascular homeostasis.

9. The data unequivocally demonstrated that BMPER is highly expressed in malignant tumors and that the growth of lung, colon, and uterine carcinomas is dependent on the presence of BMPER.

10. Bmper may play an important role in suppressing hepcidin (Montrer HAMP Anticorps) production in hypotransferrinemic mice.