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The protein encoded by CD63 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. De plus, nous expédions CD63 Anticorps (646) et CD63 Kits (40) et beaucoup plus de produits pour cette protéine.
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In renal proximal tubules, CD63 determines the insertion of OCT2 (Montrer SLC22A2 Protéines) into the proper membrane domain and mediates transporter regulation by trafficking processes.
TIMP1 (Montrer TIMP1 Protéines) signaling via CD63 leads to activation of hepatic stellate cells, which create an environment in the liver that increases its susceptibility to pancreatic tumor cells.
The Muted protein (Montrer MUTED Protéines) is important for the steady-state level of CD63.
Data show that CD63 is a crucial player in the regulation of the tumor cell-intrinsic metastatic potential by affecting cell plasticity.
These findings identify CD63 as an important component of allergic inflammation.
CD63 serves to bridge between beta1 integrin and VEGFR2 (Montrer KDR Protéines) because CD63 silencing disrupted VEGFR2 (Montrer KDR Protéines)-beta1 integrin complex formation identified using proximity ligation assay
Loss of CD63 is associated impairment of amyloidogenesis and downstream melanosome morphogenesis.
Loss of CD63 has a similar phenotype to loss of P-selectin (Montrer SELP Protéines) itself, thus CD63 is an essential cofactor to P-selectin (Montrer SELP Protéines).
CXCR4 (Montrer CXCR4 Protéines) can be downregulated on activated B cells by IL-21 (Montrer IL21 Protéines)-induced endocytosis and CD63-mediated endosomal recruitment.
The findings identify palmitoylation-dependent association with the tetraspanin CD63 as the mechanism by which Syt VII (Montrer SYT7 Protéines) is targeted to lysosomes.
Human CD63-GFP expression was controlled under the rat Sox2 (Montrer SOX2 Protéines) promoter (Sox2 (Montrer SOX2 Protéines)/human CD63-GFP), and it was expressed in undifferentiated fetal brains.
our results identify the CD63-syntenin-1 (Montrer SDCBP Protéines)-ALIX (Montrer PDCD6IP Protéines) complex as a key regulatory component in post-endocytic HPV trafficking.
Exosomal markers CD63 and CD9 (Montrer CD9 Protéines) are elevated in pancreatic tumor tissues.
CD63 and exosome expression is altered in scleroderma dermal fibroblasts
CD63 is a critical player in LMP1 (Montrer PDLIM7 Protéines) exosomal trafficking and LMP1 (Montrer PDLIM7 Protéines)-mediated enhancement of exosome production and may play further roles in limiting downstream LMP1 (Montrer PDLIM7 Protéines) signaling.
Concentrations of Cd63 were elevated in gingival crevicular fluid of patients with pre-eclampsia.
CD163 (Montrer CD163 Protéines)(+) TAMs in oral premalignant lesions coexpress CD163 (Montrer CD163 Protéines) and STAT1 (Montrer STAT1 Protéines), suggesting that the TAMs in oral premalignant lesions possess an M1 phenotype in a Th1 (Montrer TH1L Protéines)-dominated micromilieu.
Our findings reveal that elevated levels of TIMP-1 (Montrer TIMP1 Protéines) impact on neutrophil homeostasis via signaling through CD63.
These findings indicate that rhTIMP-1 promotes clonogenic expansion and survival in human progenitors via the activation of the CD63/PI3K (Montrer PIK3CA Protéines)/pAkt (Montrer AKT1 Protéines) signaling pathway
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms.
melanoma 1 antigen
, CD63 antigen
, CD63 antigen (melanoma 1 antigen)
, lysosomal-associated membrane protein 3
, lysosome-associated membrane glycoprotein 3
, melanoma-associated antigen ME491
, melanoma-associated antigen MLA1
, ocular melanoma-associated antigen
, ME491/CD63 antigen
, mast cell antigen AD1