Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) Kits ELISA

CBLB encodes a protein that catalyzes the final step in the conversion of vitamin B(12) into adenosylcobalamin (AdoCbl), a vitamin B12-containing coenzyme for methylmalonyl-CoA mutase. De plus, nous expédions Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Anticorps (71) et Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Protéines (6) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
CBLB 208650 Q3TTA7
CBLB 171136 Q8K4S7
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Fournisseur Livraison Prix Détails
Humain 25 pg/mL 78-5000 pg/mL   96 Tests Connectez-vous pour afficher 2 to 3 Days
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Plus Kits ELISA pour Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase partenaires d'interaction

Mouse (Murine) Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) interaction partners

  1. The establishment of a new model of concurrent tissue-selective CBL/CBL-B deletion should allow a clear assessment of the tumor-intrinsic roles of CBL/CBL-B in non-myeloid malignancies and help test the potential for CBL/CBL-B inactivation in immunotherapy of tumors.

  2. GSK3 catalyzes two previously unreported phosphorylation events at Ser(476) and Ser(480) of Cbl-b. Constitutive activation of PKB in vivo results in a loss of tolerance that is mediated through the downregulation of Cbl-b. The PI3K-PKB-GSK-3 pathway is a novel regulatory axis that is important for controlling the decision between T cell activation and tolerance via Cbl-b.

  3. These studies reveal a novel, cell-autonomous requirement of CBL and CBL-B in epithelial stem cell maintenance during organ development and remodeling through modulation of mTOR signaling.

  4. CBLB directs polyubiquitination of dectin-1 and dectin-2, two key pattern-recognition receptors for sensing Candida albicans, and their downstream kinase SYK, thus inhibiting dectin-1- and dectin-2-mediated innate immune responses.

  5. CBLB controls proximal C-type lectin receptor signaling in macrophages and dendritic cells. CBLB associates with SYK and ubiquitinates SYK, dectin-1, and dectin-2 after fungal recognition. CBLB deficiency results in increased inflammasome activation, enhanced reactive oxygen species production, and increased fungal killing.

  6. study indicates that Cbl-b negatively regulates CLR-mediated antifungal innate immunity

  7. Fasudil, a clinically safe ROCK inhibitor, decreases disease burden in a Cbl/Cbl-b deficiency-driven murine model of myeloproliferative disorders.

  8. Mechanistically, NFATc1 induces Nur77 expression at late stage of osteoclast differentiation; in turn, Nur77 transcriptionally up-regulates E3 ubiquitin ligase Cbl-b, which triggers NFATc1 protein degradation.

  9. Silencing Cbl-b significantly enhanced T lymphocyte function and T lymphocyte cytotoxicity activity

  10. mechanisms have therapeutic implications for reducing beta-cell proliferation in insulinomas by inhibiting phospho-HLXB9 or its interaction with Nono and modulating the expression of its direct (Cblb) or indirect (c-Met) targets

  11. SHP-1 regulates Cbl-b-mediated T cell responses by controlling its tyrosine phosphorylation and ubiquitination

  12. Cbl-b and c-Cbl regulate the degradation of Osterix through the ubiquitin-proteasome pathway.

  13. Cbl-b(-/-) T cells demonstrate significant lymph node trafficking abnormalities.

  14. These results indicated that NF-kappaB downregulated Cbl-b by binding and suppressing Cbl-b promoter in T cell activation

  15. Cbl-b, together with Stub1, ubiquitinate Foxp3, and regulate tTreg development.

  16. Whereas Cbl-PI3K interaction regulates differentiation and survival, bone resorption is predominantly regulated by Cbl-b in osteoclasts.

  17. Cbl-b acts as a scaffolding molecule to coordinate the delivery of the BCR and TLR9 into subcellular compartments required for productively delivering BCR-captured ligands to TLR9.

  18. Cbl-b is the E3 ubiquitin ligase for Stat6. Cbl-b regulates Th9 in both Stat6-dependent and -independent mechanisms.

  19. The results demonstrate an essential and non-redundant role for Cbl-b in controlling TGFbetaR signaling by directly targeting SMAD7 for degradation during T cell responses in vitro and in vivo.

  20. Cbl-b, by promoting the ubiquitination and degradation of DDR2, functions as a negative regulator in the DDR2 signaling pathway.

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB) profil antigène

Antigen Summary

E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B- cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T- cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. {ECO:0000269|PubMed:10646608, ECO:0000269|PubMed:10646609, ECO:0000269|PubMed:11070165, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:12771181, ECO:0000269|PubMed:15308098}.

Gene names and symbols associated with CBLB

  • Cbl proto-oncogene B, E3 ubiquitin protein ligase L homeolog (cblb.L) anticorps
  • Casitas B-lineage lymphoma b (Cblb) anticorps
  • Cbl proto-oncogene B (Cblb) anticorps
  • Cbl proto-oncogene B (CBLB) anticorps
  • AI429560 anticorps
  • AI851073 anticorps
  • Cbl-b anticorps
  • cblb anticorps
  • rnf56 anticorps

Protein level used designations for CBLB

Cas-Br-M (murine) ecotropic retroviral transforming sequence b , Cbl proto-oncogene, E3 ubiquitin protein ligase B , E3 ubiquitin-protein ligase CBL-B-A , SH3-binding protein CBL-B-A , signal transduction protein CBL-B-A , Casitas B-lineage lymphoma proto-oncogene b , E3 ubiquitin-protein ligase CBL-B , RING-type E3 ubiquitin transferase CBL-B , SH3-binding protein CBL-B , Signal transduction protein CBL-B , casitas B-lineage lymphoma proto-oncogene b , signal transduction protein CBL-B , Cas-Br-M (murine) ectropic retroviral transforming sequence b , Casitas B-lineage lymphoma b , Cbl proto-oncogene B, E3 ubiquitin protein ligase , LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL-B , Cas-Br-M ecotropic retroviral transforming sequence b

443854 Xenopus laevis
208650 Mus musculus
171136 Rattus norvegicus
100718857 Cavia porcellus
100621690 Sus scrofa
100355469 Oryctolagus cuniculus
525906 Bos taurus
100061819 Equus caballus
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