Charged Multivesicular Body Protein 4C Protéines (CHMP4C)

CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. De plus, nous expédions CHMP4C Anticorps (16) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
CHMP4C 66371 Q9D7F7
CHMP4C 92421 Q96CF2
CHMP4C 361916 Q569C1
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Top CHMP4C Protéines sur anticorps-enligne.fr

Showing 5 out of 5 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Escherichia coli (E. coli) Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,465.26
Détails
Escherichia coli (E. coli) Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 30 to 35 Days
$5,465.26
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$814.00
Détails
Levure Poisson Zèbre His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,561.17
Détails
Levure Rat His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,585.00
Détails

CHMP4C Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Mouse (Murine)

Human ,
,
Rat (Rattus)

Plus protéines pour Charged Multivesicular Body Protein 4C (CHMP4C) partenaires d'interaction

Human Charged Multivesicular Body Protein 4C (CHMP4C) interaction partners

  1. Data demonstrate the biological importance of the abscission checkpoint and suggest that dysregulation of abscission by CHMP4CT232 may synergize with oncogene (Montrer RAB1A Protéines)-induced mitotic stress to promote genomic instability and tumorigenesis.

  2. Results show that CHMP4C, under the regulation of the chromosomal passenger complex, binds to highly curved membranes and promotes the closure of membrane gaps. Two distinctly localized pools of phosphorylated CHMP4C exist during cytokinesisI but the phosphorylation is not required for its assembly into spiral filaments. Also, the centralspindlin complex associates preferentially with the with unphosphorylated form.

  3. CHMP4C mediates radiation resistance in lung cancer cells.

  4. The ESCRT-III subunit CHMP4B (Montrer CHMP4A Protéines) is a key effector in abscission, whereas its paralogue, CHMP4C, is a component in the abscission checkpoint that delays abscission until chromatin is cleared from the intercellular bridge.

  5. AURKB (Montrer AURKB Protéines) phosphorylates CHMP4C at 3 serines its C-terminal tail.Phosphorylation at these sites appears essential for CHMP4C function because their mutation leads to cytokinesis defects.

  6. Single nucleotide polymorphisms in CHMP4C gene is associated with ovarian cancer.

  7. findings show CHMP4C is involved in abscission timing; this function correlated with its differential spatiotemporal distribution during late stages of cytokinesis; CHMP4C functioned in the Aurora B (Montrer AURKB Protéines)-dependent abscission checkpoint

  8. The Bro1 (Montrer HMGCR Protéines) domain of ALIX (Montrer PDCD6IP Protéines) binds specifically to C-terminal residues of the human CHMP4C.

Profil protéine CHMP4C

Profil protéine

CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006

Gene names and symbols associated with CHMP4C

  • charged multivesicular body protein 4C (Chmp4c)
  • charged multivesicular body protein 4C (CHMP4C)
  • charged multivesicular body protein 4C (chmp4c)
  • charged multivesicular body protein 4C L homeolog (chmp4c.L)
  • 2010012P02Rik Protéine
  • 2210015K02Rik Protéine
  • 2310010I16Rik Protéine
  • chmp4c Protéine
  • Shax3 Protéine
  • SNF7-3 Protéine
  • VPS32C Protéine
  • zgc:110173 Protéine

Protein level used designations for CHMP4C

Snf7 homologue associated with Alix 3 , charged multivesicular body protein 4c , chromatin modifying protein 4C , chromatin-modifying protein 4c , SNF7 homolog associated with Alix 3 , hSnf7-3 , hVps32-3 , vacuolar protein sorting-associated protein 32-3 , vps32-3 , charged multivesicular body protein 4C , Chromatin-modifying protein 4c

GENE ID SPECIES
66371 Mus musculus
92421 Homo sapiens
361916 Rattus norvegicus
550542 Danio rerio
100723062 Cavia porcellus
507572 Bos taurus
444307 Xenopus laevis
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