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Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. De plus, nous expédions CBX5 Protéines (8) et CBX5 Kits (2) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal CBX5 Primary Antibody pour ChIP, IHC (p) - ABIN258235
Bawa-Khalfe, Lu, Zuo, Huang, Dere, Lin, Yeh: Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition. dans Proceedings of the National Academy of Sciences of the United States of America 2012
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Human Monoclonal CBX5 Primary Antibody pour ChIP, ICC - ABIN2668529
Shestakova, Mansuroglu, Mokrani, Ghinea, Bonnefoy: Transcription factor YY1 associates with pericentromeric gamma-satellite DNA in cycling but not in quiescent (G0) cells. dans Nucleic acids research 2004
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Human Polyclonal CBX5 Primary Antibody pour IF, WB - ABIN2452033
Wang, Koyama, Nishida, Haraguchi, Reith, Tsukamoto: The assembly and maintenance of heterochromatin initiated by transgene repeats are independent of the RNA interference pathway in mammalian cells. dans Molecular and cellular biology 2006
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Human Polyclonal CBX5 Primary Antibody pour IHC (p), IHC - ABIN250893
Rohr, Lecestre, Chasserot-Golaz, Marban, Avram, Aunis, Leid, Schaeffer: Recruitment of Tat to heterochromatin protein HP1 via interaction with CTIP2 inhibits human immunodeficiency virus type 1 replication in microglial cells. dans Journal of virology 2003
These data indicates that up-regulated HP1alpha, SUV39H1 (Montrer SUV39H1 Anticorps), and H3K9me3 in glioma cells are functionally associated with glioma pathogenesis and progression, and may serve as novel biomarkers for future diagnostic and therapeutic targeting of brain tumors.
KDM2A (Montrer KDM2A Anticorps)-SF forms distinct nuclear heterochromatic bodies in an HP1a (Montrer TFF1 Anticorps) dependent manner
Data suggest that SUMOylated heterochromatin protein 1-alpha (HP1alpha)alpha is a critical epigenetic-regulator of DNA-repair in breast cancer (BCa (Montrer BLNK Anticorps)) that could define chemotherapy responsiveness.
findings suggest that heterochromatin-mediated gene silencing may occur in part through sequestration of compacted chromatin in phase-separated HP1 (Montrer DEFA1 Anticorps) droplets, which are dissolved or formed by specific ligands on the basis of nuclear context
Data show that SALL4 (Montrer SALL4 Anticorps) promotes the expression of Glut1 (Montrer SLC2A1 Anticorps) and open chromatin through a HP1alpha-dependent mechanism.
Identify a nucleosome interaction module within KDM2A (Montrer KDM2A Anticorps) consisting of a CXXC type zinc finger, a PHD (Montrer PDC Anticorps) domain and a newly identified Heterochromatin Protein 1 (HP1 (Montrer DEFA1 Anticorps)) interaction motif that mediates direct binding between KDM2A (Montrer KDM2A Anticorps) and HP1 (Montrer DEFA1 Anticorps). This nucleosome interaction module enables KDM2A (Montrer KDM2A Anticorps) to decode nucleosomal H3K9me3 modification in addition to CpG methylation signals.
These data suggests that up-regulated HP1A (Montrer TFF1 Anticorps) and H3K9me3 in glioma cells are functionally associated with glioma pathogenesis and progression.
Loss of HP1alpha and gamma isoforms inhibits the upregulation of Suv39h1 (Montrer SUV39H1 Anticorps) and H3K9me3 that is observed under stress conditions.
we showed the essential role of HP1 (Montrer DEFA1 Anticorps) in regulating HR through BRCA1/BARD1 (Montrer BARD1 Anticorps)-mediated accumulation of FANCJ (Montrer BRIP1 Anticorps) and CtIP (Montrer RBBP8 Anticorps) at DSB sites. This mechanism may affect tumorigenesis and chemosensitivity and is thus of high clinical significance.
We demonstrate that an hnRNPA1 (Montrer HNRNPA1 Anticorps) and CBX5 bi-directional core promoter fragment does not comprise intrinsic capacity for specific CBX5 down-regulation in metastatic cells
results reveal that ADNP (Montrer ADNP Anticorps), via the recruitment of HP1 and CHD4 (Montrer CHD4 Anticorps), regulates the expression of genes that are crucial for maintaining distinct cellular states and assures accurate cell fate decisions upon external cues
HP1-alpha oligomerization is critical to the maintenance of heterochromatin and the tunable dynamics of this HP1 isoform.
demonstrate an actin-driven differential modulation of core histone H2B and heterochromatin HP1alpha protein dynamics with chromatin
the molecular behavior of HP1alpha throughout the cell cycle
There is a functional link between prelamin A, HP1alpha, chromatin remodeling, DNA repair, and early senescence in Zmpste24 (Montrer Zmpste24 Anticorps)-deficient mice, suggesting a potential therapeutic strategy for laminopathy-based premature aging via the intervention of HP1alpha.
the TIF1beta (Montrer TRIM28 Anticorps)-HP1 system functions as a critical repressive machinery that targets genes not normally activated in the hematopoietic compartment, thereby maintaining the transcriptional signature specific to HSCs.
HP1 mobility in apoptotic cells appeared to be unique.
Elimination of HP1alpha by siRNA interfered with centromere relocation from heterochromatin surrounding NPBs to pro-chromocenters at the two-cell stage but did not affect preimplantation develoment to the blastocyst stage.
Depletion of Senp7 (Montrer SENP7 Anticorps) delocalizes HP1 alpha from pericentric heterochromatin without affecting H3K9me3 levels.
The interplay between MU2 (Montrer AP2M1 Anticorps) and HP1a is dynamic and may be different in euchromatin and heterochromatin during DNA break recognition and repair.
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.
HP1 alpha homolog
, HP1Hs alpha
, antigen p25
, chromobox homolog 5 (HP1 alpha homolog, Drosophila)
, chromobox protein homolog 5
, heterochromatin protein 1 homolog alpha
, heterochromatin protein 1-alpha
, chromobox-like protein 5
, chromobox-like protein 5 (HP1 alpha homolog, Drosophila)
, HP1 alpha
, chromobox homolog 5
, heterochromatin protein 1 alpha
, chromobox homolog 5 tv3