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polymorphisms c.98T>C in the UGT1A9 (Montrer UGT1A9 Anticorps) and c.1075A>C in the CYP2C9 genes did not affect the pharmacokinetic profile of propofol
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Possession of CYP2C9*2 and/or CYP2C9*3 allele variants is associated with lower time of international normalized ratio (INR (Montrer INSR Anticorps)) in the therapeutic range (TTR (Montrer TTR Anticorps)) values and warfarin dose variations in aortic valve replacement patients, the latter affected also by VKORC1 (Montrer VKORC1 Anticorps) c.-1693G>A polymorphism
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Three SNPs (CYP2C9 *2, *3 and VKORC1 (Montrer VKORC1 Anticorps) c.-1639G > A) were genotyped by electrochemical detection using a sandwich-type format that included a 3' short thiol capture probe and a 5' ferrocene-labeled signal probe.
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This study was aimed to describe the distribution of CYP2C9 and CYP2C19 (Montrer CYP2C19 Anticorps) alleles and haplotypes in four Mestizo populations from Western Mexico. Frequencies ranged from 2.2-3.0% and 4.8-8.9% for CYP2C9*3 and CYP2C9*2 alleles, respectively, and 5.4-12.0% for CYP2C19 (Montrer CYP2C19 Anticorps)*2, whereas the CYP2C19 (Montrer CYP2C19 Anticorps)*3 allele was not found.
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CYP2C9 IVS8-109 T carriers showed significantly higher dose-corrected phenoytoin blood concentrations and this allele was found in a higher frequency in epileptic patients with supratherapeutic phenytoin levels.
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Med25 (Montrer MED9 Anticorps), a variable member of the Mediator complex, is a coactivator of ligand-activated ERalpha (Montrer ESR1 Anticorps) that interacts with ERalpha (Montrer ESR1 Anticorps) through its C-terminal LXXLL motif after BPA (Montrer DST Anticorps) exposure, and is functionally involved in BPA (Montrer DST Anticorps)-induced transcriptional regulation of CYP2C9 expression and enzyme activity.
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We conclude that CYP2C9/2C19 genotype is not relevant for variability in valproic acid exposure.
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Our results show that anticoagulated patients have a high risk of adverse events if they are carriers of 1 or more genetic polymorphisms in the VKORC1 (Montrer VKORC1 Anticorps) (rs9923231) and CYP2C9 (rs1799853 and rs1057910) genes.
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Review/Meta-analysis: CYP2C9 gene polymorphism was significantly associated with decreased warfarin maintenance dose requirements in pediatric patients.
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The intrinsic clearance (Vmax/Km) values of all variants, with the exception of CYP2C9*2, CYP2C9*11, CYP2C9*23, CYP2C9*29, CYP2C9*34, CYP2C9*38, CYP2C9*44, CYP2C9*46 and CYP2C9*48, were significantly different from CYP2C9*1. CYP2C9*27, *40, *41, *47, *49, *51, *53, *54, *56 and N418T variant exhibited markedly larger values than CYP2C9*1.
