DAN Domain Family, Member 5 Protéines (DAND5)

DAND5 encodes a member of the BMP (bone morphogenic protein) antagonist family. De plus, nous expédions DAND5 Anticorps (62) et DAND5 Kits (5) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
DAND5 199699 Q8N907
DAND5 23863 Q76LW6
DAND5 594864  
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Showing 6 out of 6 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,869.04
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
$6,869.04
Détails
Escherichia coli (E. coli) Humain His-SUMO Tag 100 μg Connectez-vous pour afficher 11 Days
$411.40
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
Levure Xenopus laevis His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,480.50
Détails
Levure Xenopus tropicalis His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,486.00
Détails

DAND5 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
, ,
Mouse (Murine)

Xenopus laevis

Plus protéines pour DAN Domain Family, Member 5 (DAND5) partenaires d'interaction

Human DAN Domain Family, Member 5 (DAND5) interaction partners

  1. High DAND5 expression is associated with tumor growth and angiogenesis in breast cancer.

  2. In this work, we report two patients with a DAND5 heterozygous non-synonymous variant (c.455G > A) in the functional domain of the DAND5 protein (p.R152H), a master regulator of Nodal signaling. Patient 1 presents left isomerism, ventricular septal defect with overriding aorta and pulmonary atresia, while patient 2 presents ventricular septal defect with overriding aorta, right ventricular hypertrophy

  3. A gain-of-function cDNA screen reveals that Coco, a secreted antagonist of TGF-beta (Montrer TGFB1 Protéines) ligands, induces dormant breast cancer cells to undergo reactivation in the lung.

Xenopus laevis DAN Domain Family, Member 5 (DAND5) interaction partners

  1. Coco binds to TGFbeta1 (Montrer TGFB1 Protéines) and enhances TGFbeta1 (Montrer TGFB1 Protéines) binding to its receptor Alk5 (Montrer TGFBR1 Protéines) thus acting as both an inhibitor and an enhancer of signaling, depending on the ligand it binds.

  2. Coco required to prevent Activin and Nodal signals in dorsal marginal side of embryo from invading the prospective ectoderm, thereby restricting endoderm- and mesoderm-inducing signals to the vegetal and marginal zones of the pre-gastrula Xenopus embryo

  3. Data suggest that Coco acts as a critical target of flow, suggesting that symmetry is broken by flow-mediated left-asymmetric release of Nodal repression at the midline.

  4. Coco directly inhibits derriere (Montrer GDF3 Protéines) and Xnr1 (Montrer NODAL Protéines), and with them define a posttranscriptionally regulated signaling center which is a necessary link in the signaling chain leading to an increased TGF-beta (Montrer TGFB1 Protéines) signal on the left side of the embryo.

Mouse (Murine) DAN Domain Family, Member 5 (DAND5) interaction partners

  1. Cerl2 plays an important role during heart development.

  2. The consequent prolonged Nodal activity in the node by the absence of Cerl2 affects local Nodal expression and prolongs its expression in the lateral plate mesoderm.

  3. Decay of Cerl2 mRNA on the left is initiated by the leftward flow and further enhanced by the operation of Wnt (Montrer WNT2 Protéines)-Cerl2 interlinked feedback loops.

  4. Study shows the cilia protein Arl13b (Montrer ARL13B Protéines) is required for left right axis specification as its absence results in heterotaxia; the defect originates in the node where Cerl2 is not downregulated and asymmetric expression of Nodal is not maintained resulting in symmetric expression of both genes.

  5. Cerl-2 plays a key role in restricting the Nodal signaling pathway toward the left side of the mouse embryo by preventing its activity in the right side

  6. cCer and mouse Cerl-2 have evolved distinct regulatory mechanisms but retained a conserved function in left-right development, which is to restrict Nodal activity to the left side of the embryo.

Profil protéine DAND5

Profil protéine

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry.

Gene names and symbols associated with DAND5

  • DAN domain BMP antagonist family member 5 (DAND5)
  • DAN domain family member 5, BMP antagonist S homeolog (dand5.S)
  • DAN domain family member 5, BMP antagonist (Dand5)
  • 51-B6 Protéine
  • cer2 Protéine
  • Cerl-2 Protéine
  • cerl2 Protéine
  • Cerr2 Protéine
  • cktsf1b3 Protéine
  • coco Protéine
  • crl2 Protéine
  • dante Protéine
  • Dte Protéine
  • grem3 Protéine
  • SP1 Protéine
  • xCoco Protéine

Protein level used designations for DAND5

DAN domain family member 5 , DAN domain family, member 5 , cerberus 2 , cerberus-like 2 , cerberus-like protein 2 , cerl-2 , cysteine knot superfamily 1, BMP antagonist 3 , gremlin-3 , cerberus-like 2 protein , dante

GENE ID SPECIES
199699 Homo sapiens
594864 Xenopus laevis
23863 Mus musculus
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