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The protein encoded by DNAJB8 belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity. De plus, nous expédions DNAJB8 Anticorps (30) et et beaucoup plus de produits pour cette protéine.
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DNAJB8 is a central and versatile player in the protein aggregation and degradation system.DNAJB8 protein keeps Parkin C289G mutant protein in a soluble, degradation-competent form.
Results show that DNAJB8 expression is induced by heat shock stress which increases side population cells and cancer stem-like cells.
Taken together, the results indicate that DNAJB8 is expressed and has role in CRC CSC/CIC and that DNAJB8 is a novel target of CRC CSC/CIC-targeting immunotherapy.
The mechanism of DNAJB6 and DNAJB8 is suppression of polyQ protein aggregation by directly binding the polyQ tract.
Cancer stem-like cell (CSC) maintenance and that it offers a candidate for CSC-targeting immunotherapy in renal cell carcinoma
DNAJB6b and DNAJB8 are superior suppressors of aggregation and toxicity of disease-associated polyglutamine proteins.
Dnajb8 has a role in tumor initiation, side population ratio and sphere formation but it is dispensable for stress responses
findings suggest that DNAJB8 plays a role in Cancer stem-like cell (CSC) maintenance and that it offers a candidate for CSC-targeting immunotherapy in renal cell carcinoma
The protein encoded by this gene belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity. This family member suppresses aggregation and toxicity of polyglutamine proteins, and the C-terminal tail is essential for this activity. It has been implicated as a cancer-testis antigen and as a cancer stem-like cell antigen involved in renal cell carcinoma.
dnaJ homolog subfamily B member 8
, DnaJ homolog 6