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Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. De plus, nous expédions ELK3, ETS-Domain Protein (SRF Accessory Protein 2) Anticorps (83) et ELK3, ETS-Domain Protein (SRF Accessory Protein 2) Protéines (5) et beaucoup plus de produits pour cette protéine.
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Dexmedetomidine attenuates pancreatic injury and inflammatory response in mice with pancreatitis possibly by reducing NLRP3 activation and up-regulating NET expression.
Elk-3 contributes to the progression of liver fibrosis by modulating the epithelial-mesenchymal transition via the regulation of Egr-1 under MAPK signaling.
Elk3 has distinct roles in maintaining retinal artery integrity.
coexpression of KLF4 led to repression of Elk-3 promoter activity
ELK3 suppresses PAI-1 expression and accumulates in the nucleus at high cell density.
Data show that Elk-1 and Net do not contribute significantly to thymocyte development in the presence of SAP-1.
Elk-3 is a strong repressor of NOS2 promoter activity and mRNA levels, and endogenous expression of Elk-3 inversely correlates with NOS2
A regulator of angiogenesis that can switch to an activator following induction by pro-angiogenic molecules.
CTP:phosphocholine cytidylyltransferase (CT) messenger RNA(mRNA) increased at S-M phase corresponding to an increase of Ets-1 protein mRNA and decrease of Net protein mRNA indicating that Net is an important endogenous repressor for CTalpha transcription
Net is a negative regulator of PAI-1 expression and is thereby involved in cell migration.
Elk-3 serves as an important repressor of heme oxygenase 1 (HO-1) gene transcription and contributes to the tight control of HO-1 gene regulation in the setting of inflammatory stimuli
Data show that hypoxia regulates Net differently from the other ternary complex factors and that Net plays a role in the hypoxic response in vivo in mice and in cells.
the Ras-Net (Elk-3) pathway involves microtubules and is inhibited by pyrazoles
Study demonstrates that miR-135a regulates cell proliferation in breast cancer by targeting ELK1 and ELK3 oncogenes, and suggests that miR-135a potentially can act as a tumor suppressor.
Decreased Net expression characterize on-small-cell lung cancer progression.
Net might play an important role in pancreatic carcinogenesis
These results suggest that the ELK3-GATA3 axis is a major pathway that promotes metastasis of breast cancer MDA-MB-231 cells
The expression levels of Elk-3 in liver cirrhosis tissues were significantly higher than those in chronic hepatitis tissues.
We revealed that activation of the PI3K/Akt pathway was the main cause of impaired autophagy in ELK3 KD. Our results suggest that targeting ELK3 may be a potential approach to overcome doxorubicin resistance in breast cancer therapeutics.
Taken together, we suggest that ELK3 is an upstream regulator of the NF-kappaB signaling pathway, the inhibition of which leads to the suppression of peritumoral lymphatic vessel development, possibly due to a low VEGFC expression.
High expression of ELK3 is associated with migration and invasion of liver cancer stem cells.
results suggest that ELK3 plays a positive role in the metastasis of BC cells by indirectly regulating MT1-MMP expression
The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response.
ELK3 plays a negative role of VEGF-induced angiogenesis through indirectly inhibiting ETS-1 function.
Net and HIF1alpha are components of distinct signaling pathways that are intricately linked
These findings suggested that loss of Net repression could augment c-fos expression and further trigger neoplastic cell proliferation, which was involved in the pathogenesis of pancreatic cancer.
The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation\; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present.
ETS domain-containing protein Elk-3
, ETS-domain protein ELK-3
, ETS-related protein ERP
, ETS-related protein NET
, ELK3, member of ETS oncogene family
, ETS-domain protein
, SRF accessory protein 2
, serum response factor accessory protein 2
, ELK3, ETS-domain protein