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Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family (By similarity). De plus, nous expédions ELMO/CED-12 Domain Containing 1 Anticorps (33) et et beaucoup plus de produits pour cette protéine.
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Data suggest that GPR124 (Montrer GPR124 Protéines) promotes cell adhesion via interaction with Elmo1 (Montrer ELMO1 Protéines)-Dock180 (Montrer DOCK1 Protéines) and intersectin 1 (Montrer ITSN1 Protéines)/2; this constitutes a previously unrecognized heteromeric complex that is putatively involved in GPR124 (Montrer GPR124 Protéines)-dependent adhesive/angiogenic responses in vascular endothelial cells. (GPR124 (Montrer GPR124 Protéines) = G-protein coupled receptor 124 (Montrer GPR124 Protéines); Elmo1 (Montrer ELMO1 Protéines) = ELMO domain-containing protein 1; Dock180 (Montrer DOCK1 Protéines) = dedicator of cytokinesis protein 1 (Montrer DOCK1 Protéines) 180 kDa)
The non-opioid sigma-1 receptor (S1R) was identified as a novel effector of GAP activity of ELMOD1-3 proteins as its direct binding to either ELMOD1 or ELMOD2 (Montrer ELMOD2 Protéines) resulted in loss of GAP activity.
Elmod1 has relatively high and selective expression in the brain but as of 2014 has not been well-studied with respect to CNS function or disease associations. It is part of the core brain ignorome. Elmod1 has a high cis (Montrer CISH Protéines)-eQTL (Montrer EQTN Protéines) in hippocampus, hypothalamus, striatum. Hearing sensitivity trait in GeneNetwork.org also maps to the region containing Elmod1.
This finding connecting ELMOD1 deficiencies with stereocilia dysmorphologies establishes a link between the Ras superfamily of small regulatory GTPases and the actin cytoskeleton dynamics of hair cell stereocilia.
Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family (By similarity).
ELMO domain containing 1
, ELMO domain-containing protein 1