Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, RH-Linked) Protéines (EPB41)

The protein encoded by EPB41, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. De plus, nous expédions Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, RH-Linked) Anticorps (65) et Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, RH-Linked) Kits (3) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
EPB41 2035 P11171
EPB41 269587 P48193
EPB41    
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Top Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, RH-Linked) Protéines sur anticorps-enligne.fr

Showing 7 out of 10 products:

Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
Détails
HEK-293 Cells Humain Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Connectez-vous pour afficher Disponible
$814.00
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
Détails
Escherichia coli (E. coli) Humain Inconjugué SDS-PAGE analysis of Human EPB41 Protein. 100 μg Connectez-vous pour afficher 11 to 18 Days
$596.97
Détails
Escherichia coli (E. coli) Souris Inconjugué SDS-PAGE analysis of Mouse EPB41 Protein. 100 μg Connectez-vous pour afficher 11 to 18 Days
$625.39
Détails
Levure Poulet His tag   1 mg Connectez-vous pour afficher 60 to 71 Days
$2,143.17
Détails

EPB41 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , , ,
, , ,
Mouse (Murine) ,
,
Chicken

Plus protéines pour Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, RH-Linked) (EPB41) partenaires d'interaction

Zebrafish Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, RH-Linked) (EPB41) interaction partners

Human Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, RH-Linked) (EPB41) interaction partners

  1. 6 Single Nucleotide Polymorphisms within the EPB41 gene are significantly associated with Mandibular Prognathism (rs2762686, rs2788888, rs4654388, rs502393, rs11581096, and rs488113). The G-allele of SNP, assigned as rs4654388, showed the strongest link with an increased risk of Mandibular Prognathism in the Chinese population.

  2. Our study shows alternative polyadenylation to be an additional mechanism for the generation of 4.1 protein diversity in the already complex EPB41-related genes. Understanding the diversity of EPB41 RNA processing is essential for a full appreciation of the many 4.1 proteins expressed in normal and pathological tissues.

  3. identification of EPB41 as a hepatocellular carcinoma susceptibility gene in vitro and in vivo; consistent with this notion, EPB41 expression is significantly decreased in HCC (Montrer FAM126A Protéines) tissue specimens, especially in portal vein metastasis or intrahepatic metastasis, compared to normal tissues

  4. The 4.1R, 4.1N (Montrer EPB41L1 Protéines) and 4.1B (Montrer EPB41L3 Protéines) are all expressed at the lateral membrane as well as cytoplasm of epithelial cells, suggesting a potentially redundant role of these proteins.

  5. Calcium mediates the conformation-based 4.1R FERM domain binding to membrane proteins by calmodulin.

  6. Results suggest a previously unidentified role for the scaffolding protein 4.1R in locally controlling CLASP2 behavior, CLASP2 cortical platform turnover and GSK3 activity, enabling correct MT organization and dynamics essential for cell polarity.

  7. We conclude that PIP2 may play an important role as a modulator of apo (Montrer C9orf3 Protéines)-CaM binding to 4.1R(80) throughout evolution.

  8. Plasmodium falciparum PF3D7_0402000 was identified as a new binding partner for the major erythrocyte cytoskeletal protein (Montrer ACTN1 Protéines), 4.1R.

  9. a novel gene region, EPB41, which may be associated with smoking cessation, along with gene regions in CNR1 (Montrer CNR1 Protéines) that may be targeted to further elucidate the etiology of gender differences in smoking behaviors.

  10. 4.1R regulates NHE1 (Montrer SLC9A1 Protéines) activity through a direct protein-protein interaction that can be modulated by intracellular pH and Na(+) and Ca(2 (Montrer CA2 Protéines)+) concentrations.

Xenopus laevis Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, RH-Linked) (EPB41) interaction partners

  1. Data hypothesize that protein 4.1 (4.1R) could function as a linker protein (Montrer LAT Protéines) between cytokeratin (Montrer KRT1 Protéines) and the actin-based cytoskeleton.

Cow (Bovine) Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, RH-Linked) (EPB41) interaction partners

  1. 4.1G interacts with a subset of CNG (Montrer CNGA1 Protéines) channels and implicate this protein-protein interaction in organizing the spatial arrangement of CNG (Montrer CNGA1 Protéines) channels in the plasma membrane of retinal outer segments.

  2. Band 4.1 protein is found in a retinal cDNA library screened for proteins interacting with the intracellular C-terminus of the metabotropic glutamate (Montrer GRIN2A Protéines) receptor isoform 8a (mGluR8a).

Mouse (Murine) Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, RH-Linked) (EPB41) interaction partners

  1. This suggests that 4.1R may influence myogenesis by preventing VHL (Montrer VHL Protéines)-mediated myogenin (Montrer MYOG Protéines) degradation.

  2. The proportion of 4.1R-positive cells was significantly higher in the HF group than in the controls, which was confirmed by the positive mRNA expression of 4.1R. 4.1R localized mostly to the plasma membrane of myocardial cells and was upregulated with the progression of HF. This suggests that 4.1R may be associated with HF progression.

  3. suggest that 4.1R can prevent pathogenic autoimmunity in MS/EAE progression by suppressing the CD4 (Montrer CD4 Protéines)(+) T cell activation

  4. Loss of 4.1/NuMA interaction results in spindle orientation defects and inhibition of Cdk1 causes increase in cortical NuMA localization

  5. a functional role for 4.1R in small intestinal calcium absorption through regulation of membrane expression of PMCA1b (Montrer ATP2B1 Protéines).

  6. At the intercalated disc 4.1R does not colocalise with the adherens junction protein, beta-catenin (Montrer CTNNB1 Protéines), but does overlap with the other plasma membrane signalling proteins, the Na/K-ATPase (Montrer ATP1A1 Protéines) and the Na/Ca exchanger NCX1 (Montrer SLC8A1 Protéines).

  7. Cell adhesion and signaling pathways regulated by alphavbeta8 integrin and Band 4.1B (Montrer EPB41L3 Protéines) are essential for normal formation and function of the heart during embryogenesis.

  8. A conserved exonic splicing silencer element (CE(16)) in protein 4.1R exon 16 (E16 (Montrer SLC7A5 Protéines)) interacts with hnRNP A/B (Montrer HNRNPAB Protéines) proteins & plays a role in repression of E16 (Montrer SLC7A5 Protéines) splicing during early erythropoiesis

  9. We speculate that over the repetitive cycles of heart muscle contraction and relaxation, 4.1R is likely to locate, support, and coordinate functioning of key membrane-bound macromolecular assemblies.[Epb41]

  10. These results suggest that erythroid protein 4.1 plays a major role in volume regulation and physiologically downregulates Na/H exchange in mouse erythrocytes.

Profil protéine Erythrocyte Membrane Protein Band 4.1 (Elliptocytosis 1, RH-Linked) (EPB41)

Profil protéine

The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with EPB41

  • erythrocyte membrane protein band 4.1b (epb41b)
  • erythrocyte membrane protein band 4.1 (EPB41)
  • erythrocyte membrane protein band 4.1 (epb41)
  • erythrocyte membrane protein band 4.1 L homeolog (epb41.L)
  • erythrocyte membrane protein band 4.1 (Epb41)
  • 4.1R Protéine
  • AI415518 Protéine
  • D4Ertd442e Protéine
  • EL1 Protéine
  • Elp-1 Protéine
  • Elp1 Protéine
  • Epb41 Protéine
  • HE Protéine
  • mKIAA4056 Protéine
  • P4.1R Protéine
  • wu:fb70c02 Protéine

Protein level used designations for EPB41

erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) , cha , mot , merlot , chablis , protein 4.1R , cytoskeletal protein 4.1 , protein 4.1 , protein 4.1-like , EPB4.1 , P4.1 , band 4.1 , erythrocyte surface protein band 4.1 , 4.1R , erythroid membrane skeletal protein 4.1 , erythroid protein 4.1

GENE ID SPECIES
326287 Danio rerio
456689 Pan troglodytes
720360 Macaca mulatta
100038195 Xenopus (Silurana) tropicalis
100226658 Taeniopygia guttata
100350667 Oryctolagus cuniculus
100402250 Callithrix jacchus
100455211 Pongo abelii
100546883 Meleagris gallopavo
100563114 Anolis carolinensis
100596891 Nomascus leucogenys
2035 Homo sapiens
442955 Canis lupus familiaris
397741 Xenopus laevis
281753 Bos taurus
396493 Gallus gallus
100515614 Sus scrofa
269587 Mus musculus
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