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Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. De plus, nous expédions EIF2S2 Anticorps (70) et beaucoup plus de produits pour cette protéine.
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Mass spectrometry of CXCR4 (Montrer CXCR4 Protéines) immunoprecipitates revealed a specific interaction with the pentameric eukaryotic translation initiation factor (Montrer EIF2A Protéines) 2B.
This study provides mechanistic insight into the role of eIF5-carboxyl terminal domain's dynamic interplay with eIF1 and eIF2beta
These findings suggest that alpha and beta subunits of eIF2 (Montrer EIF2S1 Protéines) interact with each other and the beta-subunit (Montrer POLG Protéines) plays a critical role both in the regulation and function of eIF2 (Montrer EIF2S1 Protéines).
This study provides evidence that even a mild mutation in eIF2B (Montrer EIF2B4 Protéines), leading merely to a ~ 20% decrease in its enzymatic activity, is associated with mitochondrial malfunction caused by defective oxphos and with increased mitochondrial biogenesis compensating for energetic needs.
GCN2 (Montrer EIF2AK4 Protéines) activation increased phosphorylation of its substrate eIF2alpha (Montrer EIF2A Protéines) and the induction of the integrated stress response master regulator, ATF4 (Montrer ATF4 Protéines).
BMP-2 (Montrer BMP2 Protéines) stimulates differentiation of myoblasts into osteoblasts via the PERK (Montrer EIF2AK3 Protéines)-eIF2alpha (Montrer EIF2A Protéines)-ATF4 (Montrer ATF4 Protéines) pathway but in addition stimulates Tmem119, which itself increases ATF4 (Montrer ATF4 Protéines)
This study extends our understanding of the roles played by GCN1 in GCN2 (Montrer EIF2AK4 Protéines) activation induced by a variety of stress arrangements and suggests that IMPACT and YIH1 use similar mechanisms for regulating this eIF2alpha (Montrer EIF2A Protéines) kinase.
Study found that the incidence of testicular germ cell tumor in affected males was reduced 2-fold in mice that were partially deficient for Eif2s2 and embryonic lethality occurred near the time of implantation in mice that were fully deficient for Eif2s2.
Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation.
eukaryotic translation initiation factor 2 subunit 2
, eukaryotic translation initiation factor 2 subunit beta
, protein phosphatase 1, regulatory subunit 67
, eukaryotic translation initiation factor 2, subunit 2 (beta, 38kDa)
, eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
, eukaryote initiation factor 2 beta
, eukaryotic translation initiation factor 2 beta
, eukaryotic initiation factor 2 beta (eIF-2 beta)
, eukaryotic translation initiation factor 2 subunit 2 pseudogene