FANCD2/FANCI-Associated Nuclease 1 (FAN1) Kits ELISA

FAN1 encodes a member of the myotubularin-related class 1 cysteine-based protein tyrosine phosphatases. De plus, nous expédions FAN1 Anticorps (25) et et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
FAN1 22909 Q9Y2M0
FAN1 330554 Q69ZT1
Anti-Rat FAN1 FAN1 309256  
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Livraison Prix Détails
  96 Tests 15 to 18 Days
  96 Tests 15 to 18 Days

Plus Kits ELISA pour FAN1 partenaires d'interaction

Human FANCD2/FANCI-Associated Nuclease 1 (FAN1) interaction partners

  1. We show that FAN1 binds to the expanded HTT CAG repeat DNA and its nuclease activity is not required for protection against CAG repeat expansion. These data shed new mechanistic insights into how the genetic modifiers of Huntington's disease (HD) act to alter disease progression and show that FAN1 affects somatic expansion of the CAG repeat through a nuclease-independent mechanism.

  2. The results of our study argue against the implication of pathogenic variants of FAN1 in unexplained cases of suspected genetic predisposition to colorectal polyps/cancer.

  3. hFAN1 homodimerization plays a role in biological processes that involve 5' DNA Flap cleavage.

  4. FAN1 interaction with ubiquitylated PCNA alleviates replication stress and preserves genomic integrity independently of BRCA2

  5. The structures, function, and proposed mechanisms of FAN1 nuclease are discussed, and the insights into its role in interstrand cross-links repair and in processing of stalled replication forks are provided. [REVIEW]

  6. show that DNA repair genes (fan1 and pms2) significantly modify age at onset in Huntington's Disease and Spinocerebellar Ataxias, suggesting a common pathogenic mechanism, which could operate through the observed somatic expansion of repeats

  7. FAN1 efficiently promoted DNA incision at the proper site of RPA-coated 5'-flapped DNA. Therefore, FAN1 possesses the ability to promote the ICL repair of 5'-flapped DNA covered by RPA.

  8. EXO1 and FEN1 cleaved the substrate at the boundary between the single-stranded 5' flap and the duplex, whereas FAN1 incised it three to four nucleotides in the double-stranded region.

  9. Detected FAN1 mutations in approximately 3% of families who met the Amsterdam criteria for hereditary colorectal cancer and had mismatch repair-proficient cancers with no previously associated mutations.

  10. The crystal structures of human FAN1 in complex with a 5' flap DNA substrate show that two FAN1 molecules form a head-to-tail dimer to locate the lesion, orient the DNA, and unwind a 5' flap for subsequent incision.

  11. In this work, FAN1-DNA crystal structures and biochemical data reveal that human FAN1 cleaves DNA successively at every third nucleotide

  12. Results show that FAN1 utilizes its nuclease activity-in cooperation with the BLM-FANCD2 complex-to promote replication fork restart and simultaneous suppression of new origin firing.

  13. FAN1 encodes a DNA repair enzyme, thus implicating abnormalities in DNA repair in the susceptibility to schizophrenia or autism

  14. FAN1 might be a new mitotic substrate of APC/CCdh1 that plays a key role during mitotic exit.

  15. By exome sequencing, we identified mutations in FAN1 as a cause of karyomegalic interstitial nephritis, a disorder that serves as a model for renal fibrosis.

  16. Our results suggest that FAN1 has a minor role in interstrand crosslink repair compared with true Fanconi anemia genes and exclude FAN1 as a novel FA gene.

  17. Two FAN1 variants do not appear to be causal for breast cancer.

  18. Data show that FAN1 in DT40 cells participates in the processing of damage induced by interstrand cross-linking-generating agents also independently of the classical FA pathway.

  19. Data show that FAN1 is a nuclear protein and forms DNA-damage-induced foci, which appear to be at stalled replication forks as denoted by RPA colocalization.

  20. study characterizes FANI which promotes DNA interstrand cross-linking repair in a manner strictly dependent on its ability to accumulate at or near sites of DNA damage and that relies on mono-ubiquitylation of the FANCI-FANCD2 complex

Mouse (Murine) FANCD2/FANCI-Associated Nuclease 1 (FAN1) interaction partners

  1. FAN1 plays important role in protecting against somatic expansions but is either not involved in protecting against intergenerational repeat expansions or is redundant with other related enzymes.

  2. Our data show that Fan1 is involved in the physiologic response of kidney tubular cells to DNA damage, which contributes to the pathogenesis of chronic kidney disease. Moreover, Fan1(-/-) mice provide a new model with which to study the pathomechanisms of chronic kidney disease

  3. Fan1 nuclease activity promotes ICL repair in a manner that controls ploidy

  4. ubiquitin-binding zinc finger (UBZ) domain of FAN1, which is needed for interaction with FANCD2, is not required for the initial rapid recruitment of FAN1 to ICLs or for its role in DNA ICL resistance.

  5. Fan1 recruitment enables processing of stalled forks that is essential for genome stability and health.

FAN1 profil antigène

Antigen Summary

This gene encodes a member of the myotubularin-related class 1 cysteine-based protein tyrosine phosphatases. The encoded protein may be catalytically inactive. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with FAN1

  • FANCD2 and FANCI associated nuclease 1 (FAN1) anticorps
  • FANCD2/FANCI-associated nuclease 1 (Fan1) anticorps
  • FANCD2/FANCI-associated nuclease 1 (fan1) anticorps
  • FANCD2/FANCI-associated nuclease 1 (FAN1) anticorps
  • FANCD2 and FANCI associated nuclease 1 (Fan1) anticorps
  • 6030441H18Rik anticorps
  • fi39f01 anticorps
  • KIAA1018 anticorps
  • KMIN anticorps
  • mtmr15 anticorps
  • RGD1566323 anticorps
  • si:ch211-163b1.2 anticorps
  • si:ch211-201b11.2 anticorps
  • wu:fd06a07 anticorps
  • wu:fi39f01 anticorps

Protein level used designations for FAN1

coiled-coil domain-containing protein MTMR15 , fanconi anemia associated nuclease 1 , fanconi-associated nuclease 1 , myotubularin-related protein 15 , myotubularin related protein 15 , Fanconi-associated nuclease 1

22909 Homo sapiens
330554 Mus musculus
565458 Danio rerio
100481860 Ailuropoda melanoleuca
415383 Gallus gallus
479017 Canis lupus familiaris
100154519 Sus scrofa
508171 Bos taurus
309256 Rattus norvegicus
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