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Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains.
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Human Polyclonal FAM38B Primary Antibody pour ICC, IF - ABIN4345486
Florez-Paz, Bali, Kuner, Gomis: A critical role for Piezo2 channels in the mechanotransduction of mouse proprioceptive neurons. dans Scientific reports 2016
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Human Polyclonal FAM38B Primary Antibody pour ICC, IF - ABIN4345484
Lee, Leddy, Chen, Lee, Zelenski, McNulty, Wu, Beicker, Coles, Zauscher, Grandl, Sachs, Guilak, Liedtke: Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. dans Proceedings of the National Academy of Sciences of the United States of America 2014
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Human Polyclonal FAM38B Primary Antibody pour ICC, IF - ABIN4345487
Poole, Herget, Lapatsina, Ngo, Lewin: Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch. dans Nature communications 2014
This study identified Piezo2 mechanosensitive cationic channel as a transducer of environmental physical cues into mechanobiological responses.
The present results demonstrate the occurrence of Piezo2 in cutaneous sensory nerve formations that functionally work as slowly adapting (Merkel cells) and rapidly adapting (Meissner's corpuscles) low-threshold mechanoreceptors and are related to fine and discriminative touch but not to vibration or hard touch
Study demonstrate the splicing of Piezo2 to be cell type specific. Biophysical characterization revealed substantial differences in ion permeability, sensitivity to calcium modulation, and inactivation kinetics among Piezo2 splice variants.
we report the developmental phenotypic spectrum of familial Gordon syndrome in one family due to the previously characterized PIEZO2 mutation c.8057G>A.
Enterochromaffin cells in the human and mouse small bowel GI epithelium selectively express the mechanosensitive ion channel Piezo2, and also that activation of Piezo2 by force leads to inward currents, 5-HT (Montrer DDC Anticorps) release and an increase in mucosal secretion
The Piezo2 convert a variety of mechanical stimuli into channel activation and subsequent inactivation, and what molecules and mechanisms modulate Piezo function.
we report a consanguineous family with three siblings who showed short stature, scoliosis, gross motor impairment, and a progressive form of contractures involving the distal joints that is distinct from that found in patients with domina Recessive mutations in PIEZO2 thus appear to cause a progressive phenotype that overlaps with, while being mostly distinct from that associated with dominant mutations in the same gene
Sensory ataxia and proprioception defect with dorsal column involvement together with arthrogryposis, myopathy, scoliosis and progressive respiratory failure may represent a distinct clinical phenotype, and indicate recessive mutations in PIEZO2
We identified homozygous loss of function variants in PIEZO2 as the underlying cause for an autosomal-recessive distal muscular atrophy with arthrogryposis, kyphoscoliosis, and neonatal respiratory insufficiency distinct from previously described dominant PIEZO2 diseases.
Our results show that PIEZO2 is a determinant of mechanosensation in humans.
Mechanoinsensitive ''silent'' nociceptors are characterized by the expression of the nicotinic acetylcholine receptor subunit alpha (Montrer CHRNA1 Anticorps)-3 (CHRNA3 (Montrer CHRNA3 Anticorps)); the mechanically gated ion channel PIEZO2 mediates NGF (Montrer NGFB Anticorps)-induced mechanosensitivity in these neurons.
Targeted genetic deletion of Merkel cells and associated mechanosensitive Piezo2 channels in the skin was sufficient to produce alloknesis.
Data provide evidence that Piezo2 plays a critical role in a defined homogeneous population of proprioceptor neurons that innervate the head muscles, demonstrating that this ion channel is essential for mammalian proprioceptive mechanotransduction.
Data show that Piezo2 knockdown led to decreased glioma angiogenesis and reduced vascular hyperpermeability.
experiments demonstrate a role for Pericentrin (Montrer PCNT Anticorps) in modulating Piezo2 activity and membrane expression in somatosensory neurons
Piezo2 is an airway stretch sensor; Piezo2-mediated mechanotransduction within various airway-innervating sensory neurons is critical for establishing efficient respiration at birth and maintaining normal breathing in adult mice
Astrocytes in optic nerve head express multiple mechanosensitive channels, in particular Piezo1 (Montrer PIEZO1 Anticorps) and 2. The expression of putative mechanosensitive channels in these cells may contribute to their responsiveness to traumatic or glaucomatous injury.
mice lacking Piezo2 in both adult sensory neurons and Merkel cells exhibit a profound loss of touch sensation
Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The PIEZO2 protein has a role in rapidly adapting mechanically activated (MA) currents in somatosensory neurons (Coste et al., 2010
family with sequence similarity 38, member B
, family with sequence similarity 38, member B2
, protein PIEZO2