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FERMT1 encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. De plus, nous expédions FERMT1 Kits (6) et FERMT1 Protéines (5) et beaucoup plus de produits pour cette protéine.
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The rof/kindlin-1 mutant zebrafish provides a unique model system to study epidermal adhesion mechanisms in vivo.
these data define a novel role for Kin1 in microtubule acetylation and stability
These results indicate that Kindlin-1 is essential in EGF (Montrer EGF Anticorps)-induced re-epithelialization in skin wound healing and provide additional rationale for the clinical application of EGF (Montrer EGF Anticorps) in the treatment of acute wounds.
By modulating its affinity with kindlin, beta3 integrin (Montrer ITGB3 Anticorps) may be able to locate near the cell edge where it can control beta1 integrin activation and clustering.
Kindlin-1 is highly expressed in epithelial tissues derived from ectoderm and endoderm. Kindlin-1 was als (Montrer FERMT2 Anticorps)o found highly expressed in endoderm/ectoderm-derived tissues in embryos.
Kindlin-1 controls keratinocyte adhesion through beta1-class integrins and proliferation and differentiation of cutaneous epithelial stem cells via TGF-beta (Montrer TGFB1 Anticorps) activation and Wnt (Montrer WNT2 Anticorps)-beta-catenin (Montrer CTNNB1 Anticorps) signal inhibition.
Kindlin-1 and Kindlin-2 (Montrer FERMT2 Anticorps) have opposite roles in lung cancers
Kindlin-1 in mice gives rise to skin atrophy and an intestinal epithelial dysfunction with similarities to human ulcerative colitis.
Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects
we demonstrated that Kindlin-1 promotes CRC (Montrer CALR Anticorps) progression by recruiting SARA (Montrer ZFYVE9 Anticorps) and Smad3 (Montrer SMAD3 Anticorps) to TbetaRI (Montrer TGFBR1 Anticorps) and thereby activates TGF-beta (Montrer TGFB1 Anticorps)/Smad3 (Montrer SMAD3 Anticorps) signaling. Thus, Kindlin-1 is a novel regulator of TGF-beta (Montrer TGFB1 Anticorps)/Smad3 (Montrer SMAD3 Anticorps) signaling and may also be a potential target for CRC (Montrer CALR Anticorps) therapeutics.
Sequence analysis of KIND1 exons in patient 1 revealed a commonly reported homozygous nonsense mutation in exon 6 (c.811C>T;p.R271X). Both Patients 2 and 3 had novel homozygous single nucleotide deletions
keratinocytes derived from KS patients are unable to undergo electrotaxis, and this defect is restored by overexpression of wild-type kindlin-1 but not a W612A mutation that prevents kindlin-integrin binding.
FERMT1 activates the beta-catenin (Montrer CTNNB1 Anticorps) transcriptional activity to promote EMT (Montrer ITK Anticorps) in CC metastasis.
KIND1 is important not only for keratinocyte proliferation but also for the suppression of UV-induced inflammation and DNA damage.
We show a direct relationship between kindlin-1 abundance and UV-B induced apoptosis in keratinocytes, whereas kindlin-2 (Montrer FERMT2 Anticorps) overexpression has no compensatory effect.
KS is caused by mutations in the FERMT1 gene. Including the present, more than 60 mutations in FERMT1 have been identified since 2003. In spite of the expanding FERMT1 mutation database, there seems to be a lack of a clear genotype-phenotype correlation in KS
A nonsense mutation in Exon 5 of KIND1 Gene in an Iranian Family may lead to incomplete and non-functional protein products and is pathogenic and has meaningful implications for the diagnosis of patients with Kindler syndrome.
Kindlin1 knockdown resulted in developmental delays, gross malformations of the gut (Montrer GUSB Anticorps) and eventual lethality by tadpole stages.
This gene encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. The encoded protein is involved in integrin signaling and linkage of the actin cytoskeleton to the extracellular matrix. Mutations in this gene have been linked to Kindler syndrome.
fermitin family member 1
, fermitin family homolog 1
, fermitin family homolog 1-like
, unc-112-related protein 1
, UNC112 related protein 1
, kindlin 1
, kindlin syndrome protein
, UNC-112 related protein 1