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FERMT1 encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. De plus, nous expédions FERMT1 Kits (7) et FERMT1 Protéines (5) et beaucoup plus de produits pour cette protéine.
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Kindlin-1 is mainly expressed in the cytoplasm of normal esophageal squamous epithelium and Esophageal cancer (EC) cells. Kindlin-1 expression is positively correlated with tumor cell differentiation and is higher in stage I tumors. Kindlin-1 expression is higher in non-smoker patients than in smoker patients, and in patients with a family history of EC.
Kindlin supports platelet GPIIB IIIA activation by interacting with paxillin (Montrer PXN Anticorps).
we demonstrated that Kindlin-1 promotes CRC (Montrer CALR Anticorps) progression by recruiting SARA (Montrer ZFYVE9 Anticorps) and Smad3 (Montrer SMAD3 Anticorps) to TbetaRI (Montrer TGFBR1 Anticorps) and thereby activates TGF-beta (Montrer TGFB1 Anticorps)/Smad3 (Montrer SMAD3 Anticorps) signaling. Thus, Kindlin-1 is a novel regulator of TGF-beta (Montrer TGFB1 Anticorps)/Smad3 (Montrer SMAD3 Anticorps) signaling and may also be a potential target for CRC (Montrer CALR Anticorps) therapeutics.
Sequence analysis of KIND1 exons in patient 1 revealed a commonly reported homozygous nonsense mutation in exon 6 (c.811C>T;p.R271X). Both Patients 2 and 3 had novel homozygous single nucleotide deletions
these data define a novel role for Kin1 in microtubule acetylation and stability
keratinocytes derived from KS patients are unable to undergo electrotaxis, and this defect is restored by overexpression of wild-type kindlin-1 but not a W612A mutation that prevents kindlin-integrin binding.
FERMT1 activates the beta-catenin (Montrer CTNNB1 Anticorps) transcriptional activity to promote EMT (Montrer ITK Anticorps) in CC metastasis.
KIND1 is important not only for keratinocyte proliferation but also for the suppression of UV-induced inflammation and DNA damage.
We show a direct relationship between kindlin-1 abundance and UV-B induced apoptosis in keratinocytes, whereas kindlin-2 (Montrer FERMT2 Anticorps) overexpression has no compensatory effect.
These results indicate that Kindlin-1 is essential in EGF (Montrer EGF Anticorps)-induced re-epithelialization in skin wound healing and provide additional rationale for the clinical application of EGF (Montrer EGF Anticorps) in the treatment of acute wounds.
loss of Kindlin-1 leads to an imbalance in the cellular oxidative state, which renders Kindlin-1 deficient cells more prone to the effects of reactive oxygen species generated in response to oxidative stress
By modulating its affinity with kindlin, beta3 integrin (Montrer ITGB3 Anticorps) may be able to locate near the cell edge where it can control beta1 integrin activation and clustering.
Kindlin-1 is highly expressed in epithelial tissues derived from ectoderm and endoderm. Kindlin-1 was also found highly expressed in endoderm/ectoderm-derived tissues in embryos.
Kindlin-1 controls keratinocyte adhesion through beta1-class integrins and proliferation and differentiation of cutaneous epithelial stem cells via TGF-beta (Montrer TGFB1 Anticorps) activation and Wnt (Montrer WNT2 Anticorps)-beta-catenin (Montrer CTNNB1 Anticorps) signal inhibition.
Kindlin-1 and Kindlin-2 (Montrer FERMT2 Anticorps) have opposite roles in lung cancers
Kindlin-1 in mice gives rise to skin atrophy and an intestinal epithelial dysfunction with similarities to human ulcerative colitis.
Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects
Kindlin1 knockdown resulted in developmental delays, gross malformations of the gut (Montrer GUSB Anticorps) and eventual lethality by tadpole stages.
The rof/kindlin-1 mutant zebrafish provides a unique model system to study epidermal adhesion mechanisms in vivo.
This gene encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. The encoded protein is involved in integrin signaling and linkage of the actin cytoskeleton to the extracellular matrix. Mutations in this gene have been linked to Kindler syndrome.
UNC112 related protein 1
, fermitin family homolog 1
, kindlin 1
, kindlin syndrome protein
, unc-112-related protein 1
, UNC-112 related protein 1
, fermitin family member 1
, fermitin family homolog 1-like