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Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a 110-amino acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3 alpha helices flanked by 2 large loops or wings. De plus, nous expédions FOXN4 Protéines (2) et beaucoup plus de produits pour cette protéine.
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Evidence that FOXN4 functioned as a tumor suppressor in breast cancer and its action was through the activation of TP53 and suppression of Notch signaling.
adult thymus is the only major site of foxn4 expression outside of the nervous system
the mosaic expression of Foxn4 and proneural factors may serve as the trigger to initiate asymmetric Dll4-Notch and subsequent BMP/TGFbeta signaling events required for neuronal diversity in the V2 domain.
Mouse Foxn4 transfection reduced by 2.7-fold the basal level of Tbx2 promoter transcription, but deletion of the AD domain increased transcription showing that this domain might be a transregulatory domain.
Foxn4 has an intrinsic activity to suppress the alternative photoreceptor cell fates of early retinal progenitors by selectively activating Dll4-Notch signaling.
Foxn4 may have a non-cell-autonomous role critical for alveologenesis during lung development.
findings show that Foxn4 is required for proper outgrowth of retinal ganglion cell (RGC) axons in vivo, suggesting a role for an amacrine cell-RGC interaction in axon growth
Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord.
Foxn4 induces expression of delta-like 4 (Dll4) and Mash1 (Ascl1). Dll4 then signals through Notch1 to subdivide the p2 progenitor pool in the ventral spinal cord.
expressed during neural development in the retina, the ventral hindbrain and spinal cord and dorsal midbrain
The results indicate that Foxn4 complements Foxj1 transcriptionally during Multiciliated cell differentiation, thereby shaping the levels of gene expression required for the timely and complete biogenesis of multiple motile cilia.
Study reports that FoxN4 is expressed in the eye from the earliest stages of specification through retinal maturation, it is also expressed in the pallium, optic tectum, isthmus, reticular formation, and in cells lining the ventricle of the tadpole brain.
Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a 110-amino acid DNA-binding domain that can fold into a variant of the helix-turn-helix motif consisting of 3 alpha helices flanked by 2 large loops or wings. These transcription factors are involved in a variety of biologic processes as key regulators in development and metabolism (Li et al., 2004
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