Profil protéine

L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose\; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream TNNI3 interacting kinase (TNNI3K) gene.

Gene names and symbols associated with FPGT

• fucose-1-phosphate guanylyltransferase (fpgt) anticorps
• fucose-1-phosphate guanylyltransferase (FPGT) anticorps
• fucose-1-phosphate guanylyltransferase L homeolog (fpgt.L) anticorps
• fucose-1-phosphate guanylyltransferase (Fpgt) anticorps

• 1700016E03Rik anticorps
• DDBDRAFT_0186414 anticorps
• DDBDRAFT_0233144 anticorps
• DDB_0186414 anticorps
• DDB_0233144 anticorps
• Afficher tous les alias de synonymes
• DKFZp459M111 anticorps
• fpgt anticorps
• GFPP anticorps
• zgc:110694 anticorps

Protein level used designations for FPGT

fucose-1-phosphate guanylyltransferase , Fucose-1-phosphate guanylyltransferase , fucose-1-phosphate guanylyltransferase-like , GDP-L-fucose diphosphorylase , GDP-beta-L-fucose pyrophosphorylase , fucose-1-phosphate guanyltransferase , gdp-L-fucose pyrophosphorylase