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GPR64 encodes a member of the G protein-coupled receptor family described as an epididymis-specific transmembrane protein.
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identified two missense variants in two congenital bilateral absence of the vas (Montrer AVP Anticorps) deferens (CBAVD) patients (c.G1709A, p.C570Y; and c.A2968G, p.K990E); study did not find any potential pathogenic CFTR (Montrer CFTR Anticorps) variants, implying the ADGRG2 variants are the genetic cause in these patients
GPR64 is expressed on the cell surface of parathyroid cells, is overexpressed in parathyroid tumors, and physically interacts with the CaSR (Montrer CASR Anticorps).
study confirms the crucial role of ADGRG2 in human male fertility and brings new insight into congenital obstructive azoospermia pathogenesis; in men with CBAVD who are CFTR (Montrer CFTR Anticorps)-negative, ADGRG2 testing could allow for appropriate genetic counseling with regard to the X-linked transmission of the molecular defect
Knockdown of ADGRG2 breast cancer cell lines resulted in a strong reduction in cell adhesion and subsequent cell migration which was associated with a selective reduction in RelB (Montrer RELB Anticorps).
examined the G protein-coupling abilities of GPR64 and showed that it is activated through a tethered agonist sequence, which we have previously identified as the Stachel sequence
GPR64 expression in ES maintains an immature phenotype that is less sensitive to TRAIL-induced apoptosis and via its up-regulation of PGF (Montrer PTGFR Anticorps) and MMP1 (Montrer MMP1 Anticorps) orchestrates and promotes invasiveness and metastatic spread in Ewing sarcoma.
The knockout of the HE6/Gpr64 receptor was mainly associated with the downregulation of genes specific to the initial segment.
Affymetrix expression profiling shows that the C terminus of Runx2 (Montrer RUNX2 Anticorps) regulates genes involved in G protein-coupled receptor (Montrer GPR34 Anticorps) signaling Rgs2 (Montrer RGS2 Anticorps), Rgs4 (Montrer RGS4 Anticorps), Rgs5 (Montrer RGS5 Anticorps), Rgs16 (Montrer RGS16 Anticorps), Gpr23 (Montrer LPAR4 Anticorps), Gpr30 (Montrer GPER Anticorps), Gpr54 (Montrer KISS1R Anticorps), Gpr64, and Gna13 (Montrer GNA13 Anticorps).
This gene encodes a member of the G protein-coupled receptor family described as an epididymis-specific transmembrane protein. The encoded protein may be proteolytically processed as it contains a motif shown to be a protein scission motif in some members of this family (PMID: 11973329). Multiple transcript variants encoding different isoforms have been found for this gene.
G protein-coupled receptor 64
, G-protein coupled receptor 64-like
, G protein-coupled receptor, epididymis-specific (seven transmembrane family)
, G-protein coupled receptor 64
, epididymal protein 6
, human epididymis-specific protein 6
, LNB-TM7 heptahelical receptor Me6
, epididymis-specific protein 6
, re6 receptor