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GPR64 encodes a member of the G protein-coupled receptor family described as an epididymis-specific transmembrane protein. De plus, nous expédions GPR64 Protéines (6) et beaucoup plus de produits pour cette protéine.
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identified two missense variants in two congenital bilateral absence of the vas deferens (CBAVD) patients (c.G1709A, p.C570Y; and c.A2968G, p.K990E); study did not find any potential pathogenic CFTR variants, implying the ADGRG2 variants are the genetic cause in these patients
GPR64 is expressed on the cell surface of parathyroid cells, is overexpressed in parathyroid tumors, and physically interacts with the CaSR.
study confirms the crucial role of ADGRG2 in human male fertility and brings new insight into congenital obstructive azoospermia pathogenesis; in men with CBAVD who are CFTR-negative, ADGRG2 testing could allow for appropriate genetic counseling with regard to the X-linked transmission of the molecular defect
Knockdown of ADGRG2 breast cancer cell lines resulted in a strong reduction in cell adhesion and subsequent cell migration which was associated with a selective reduction in RelB.
This gene encodes a member of the G protein-coupled receptor family described as an epididymis-specific transmembrane protein. The encoded protein may be proteolytically processed as it contains a motif shown to be a protein scission motif in some members of this family (PMID: 11973329). Multiple transcript variants encoding different isoforms have been found for this gene.
G protein-coupled receptor 64
, G-protein coupled receptor 64-like
, G protein-coupled receptor, epididymis-specific (seven transmembrane family)
, G-protein coupled receptor 64
, epididymal protein 6
, human epididymis-specific protein 6
, LNB-TM7 heptahelical receptor Me6
, epididymis-specific protein 6
, re6 receptor