General Transcription Factor IIA, 1-Like Protéines (GTF2A1L)

The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of TFIIA on the interaction between TATA-binding protein (TBP) and DNA. De plus, nous expédions GTF2A1L Anticorps (48) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
GTF2A1L 11036 Q9UNN4
GTF2A1L 71828 Q8R4I4
Rat GTF2A1L GTF2A1L 316711  
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,797.11
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Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 60 Days
$9,797.11
Détails
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
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Escherichia coli (E. coli) Humain His tag Validation with Western Blot 50 μg Connectez-vous pour afficher Disponible
$284.90
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GTF2A1L Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human , ,
,
Mouse (Murine)

Plus protéines pour General Transcription Factor IIA, 1-Like (GTF2A1L) partenaires d'interaction

Human General Transcription Factor IIA, 1-Like (GTF2A1L) interaction partners

  1. Our results provided a new insight into susceptibility of USF1 (Montrer USF1 Protéines) variant with male infertility. rs11204546 of OR2W3 (Montrer OR2W3 Protéines) and rs11677854 of GTF2A1L might be additional valuable molecular predictive markers

  2. A unique CpG-specific methylation pattern at the ALF promoter precedes expression in pachytene spermatocytes.

  3. Results identified ALF as a human spermatogenesis related (Montrer SYCE2 Protéines) gene, the abnormal expression of ALF might be the partial cause for human infertility.

  4. TFIIA (Montrer GTF2A1 Protéines) tau is associated with undifferentiated cells during development, yet is down-regulated at the chromatin level upon cellular differentiation.

Mouse (Murine) General Transcription Factor IIA, 1-Like (GTF2A1L) interaction partners

  1. Taspase1 cleaves a ubiquitously expressed GTF (TFIIA (Montrer GTF2A1 Protéines)) to enable tissue-specific (testis) transcription, meeting the demand for sophisticated regulation of distinct subsets of genes in higher organisms.

  2. a role for ALF in the assembly and stabilization of initiation complexes in germ cells is likely to be similar or identical to the role of TFIIA (Montrer GTF2A1 Protéines) in somatic cells.

  3. unique core promoter that is active in both male and female reproductive tissue suggesting ALF may have a regulatory role in male and female gametogenic gene expression programs.

  4. Endogenous ALF is proteolytically cleaved to give alpha- and beta-subunits and its cleavage site was mapped.

Profil protéine GTF2A1L

Profil protéine

The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of TFIIA on the interaction between TATA-binding protein (TBP) and DNA. This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants, encoding distinct isoforms, have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.

Gene names and symbols associated with GTF2A1L

  • general transcription factor IIA subunit 1 like (GTF2A1L)
  • general transcription factor IIA, 1-like (Gtf2a1l)
  • general transcription factor 2A subunit 1 like (Gtf2a1l)
  • 1700011N16Rik Protéine
  • Alf Protéine
  • Gtf2a1lf Protéine

Protein level used designations for GTF2A1L

GTF2A1-like factor , TFIIA large subunit isoform ALF , TFIIA-alpha and beta-like factor , TFIIA-alpha/beta-like factor , general transcription factor II A, 1-like factor , TfIIa-alpha/beta-like factor , general transcription factor IIA, 1-like factor

GENE ID SPECIES
11036 Homo sapiens
71828 Mus musculus
316711 Rattus norvegicus
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