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The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4.
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Human Monoclonal ITPKB Primary Antibody pour ELISA, WB - ABIN561565
Nalaskowski, Fliegert, Ernst, Brehm, Fanick, Windhorst, Lin, Giehler, Hein, Lin, Mayr: Human inositol 1,4,5-trisphosphate 3-kinase isoform B (IP3KB) is a nucleocytoplasmic shuttling protein specifically enriched at cortical actin filaments and at invaginations of the nuclear envelope. dans The Journal of biological chemistry 2011
Human Polyclonal ITPKB Primary Antibody pour IHC, IHC (p) - ABIN4327792
Jin, Liu, Zhang, Huang, Jiang, Hou, Xu, Zhai, Gao, Wang, Wu, Zhu, Lu: The Expression of miR-375 Is Associated with Carcinogenesis in Three Subtypes of Lung Cancer. dans PLoS ONE 2015
Thus, non-canonical phosphoinositide 3-kinase-antagonism by Itpkb restricts pre-T cell receptor (Montrer PTCRA Anticorps) induced metabolic activation to enforce coincidence-detection of pre-T cell receptor (Montrer PTCRA Anticorps) expression and Notch (Montrer NOTCH1 Anticorps)-engagement.
These data identify Itpkb as an essential mediator of T cell activation and suggest Itpkb inhibition as a novel approach to treat autoimmune disease.
Itpkb controls hematopoietic stem cell homeostasis and prevent death from severe anemia in mice.
Itpkb controls survival, proliferation and cytokine production in mouse peripheral T cells.
Data present the structure of the complete catalytic domain of inositol 1,4,5-trisphophate 3-kinase B, including the CaM binding domain in complex with Mg(2 (Montrer MCOLN1 Anticorps)+) and ATP.
These data show that the absence of expression of the three isoenzymes of Itpk does not prevent the formation of IP5 and IP6 (Montrer GPRIN2 Anticorps), at least in mouse embryonic fibroblasts.[Itpka (Montrer ITPKA Anticorps), Itpkb, Itpkc (Montrer ITPKC Anticorps)]
Itpkb and inositol tetrakisphosphate mediate a survival signal in B cells.
B cells from Itpkb(-/-) Ig hen (Montrer RPS6 Anticorps) egg lysozyme (Montrer LYZ Anticorps) mice possess an anergic phenotype, hypoproliferate in response to cognate Ag, and yet they exhibit enhanced Ag-induced calcium signaling
miR (Montrer MLXIP Anticorps)-140-5p regulates this context-specific autophagy through its target, inositol 1,4,5-trisphosphate kinase 2 (IP3k2). Therefore, the results of the present study demonstrated that miR (Montrer MLXIP Anticorps)-140-5p mediated drug-resistance in osteosarcoma cells by inducing autophagy.
The authors confirm downregulation of miR (Montrer MLXIP Anticorps)-132 and upregulation of ITPKB in three distinct human Alzheimer's disease patient cohorts.
ITPKB is increased in Alzheimer's brain three-fold in the cerebral cortex of most patients with Alzheimer's disease compared with control subjects and accumulates in dystrophic neurites associated with amyloid plaques.
a specific increase in inositol 1,4,5-trisphosphate 3-kinase A (Montrer ITPKA Anticorps) and B (ITPKA (Montrer ITPKA Anticorps) and ITPKB) was observed upon hESCs spontaneous differentiation.
IP3KB not only regulates cytoplasmic Ca(2 (Montrer CA2 Anticorps)+) signals by phosphorylation of subplasmalemmal and cytoplasmic Ins (Montrer INS Anticorps)(1,4,5)P(3) but may also be involved in modulating nuclear Ca(2 (Montrer CA2 Anticorps)+) signals generated from these nuclear envelope invaginations.
results highlight the potential role of the three isoforms of InsP3 3-kinase as direct InsP3 metabolizing enzymes and direct regulators of Ca2 (Montrer CA2 Anticorps)+ responses to extracellular signals
We aim to summarize the existing information about functionally uncoupled IP(3)R (Montrer ITPR1 Anticorps) and RyR (Montrer RYR1 Anticorps) channels, and to discuss the concept that those channels can participate in Ca(2 (Montrer CA2 Anticorps)+)-leak pathways.
In each of the three isoforms a nuclear export signal has evolved in the catalytic domain either de novo (IP3K-A (Montrer ITPKA Anticorps)) or as a substitute for an earlier evolved corresponding N-terminal signal (IP3K-B and IP3K-C (Montrer ITPKC Anticorps)).
The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity.
inositol-trisphosphate 3-kinase B
, inositol 1,4,5-trisphosphate 3-kinase B
, 1D-myo-inositol-trisphosphate 3-kinase B
, inositol-trisphosphate 3-kinase B-like
, IP3 3-kinase B
, IP3K B
, insP 3-kinase B
, proliferation-inducing protein 37