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The protein encoded by KRT13 is a member of the keratin gene family.
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this study reports that KRT13 plays a directive role in prostate cancer bone, brain, and soft tissue metastases
Keratin 13 gene is epigenetically suppressed during TGFB1 (Montrer TGFB1 Kits ELISA)-induced epithelial-mesenchymal transition in a human keratinocyte cell line.
Four rare missense variants were identified (ACTBL2 (Montrer ACTBL2 Kits ELISA) rs73757391 (5q11.2), BTD (Montrer BTD Kits ELISA) rs200337373 (3p25.1), KRT13 rs150321809 (17q21.2) and MC2R (Montrer MC2R Kits ELISA) rs104894658 (18p11.21)), but only MC2R (Montrer MC2R Kits ELISA) rs104894668 had a large effect size (OR = 9.66).
KRT13 expression is associated with poor prognosis at multiple stages of disease progression
Loss of CK13 expression is associated with invasive oral squamous cell carcinoma.
Low KRT13 mRNA expression is associated with oral squamous cell carcinoma.
Decreased KRT13 was associated with Esophageal Squamous Cell Carcinoma.
Our data provide mechanistic insights into the epigenetic silencing of KRT13 genes in OSCC cells and might be useful for the development of diagnostic markers and novel therapeutic approaches against OSCCs.
The immunofluorescent staining pattern of Wnt1 (Montrer WNT1 Kits ELISA) and CK7 (Montrer KRT7 Kits ELISA) as well as Wnt1 (Montrer WNT1 Kits ELISA) and CK13 was consistent with IHC results. Thus, in pleomorphic adenoma, Wnt (Montrer WNT2 Kits ELISA) is involved in tumor cell differentiation of peripheral columnar cells forming solid nests
Immunoexpression of CK13 and CK17 (Montrer KRT17 Kits ELISA) in light green-stained superficial cells was associated with more severe morphological atypia in tongue squamous cell carcinoma
denervation caused an increase of Keratin (Krt)13 expression around taste buds
K13 cooperates with Myc (Montrer MYC Kits ELISA) to promote lymphoma through elevated NF-kappaB (Montrer NFKB1 Kits ELISA).
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This type I cytokeratin is paired with keratin 4 and expressed in the suprabasal layers of non-cornified stratified epithelia. Mutations in this gene and keratin 4 have been associated with the autosomal dominant disorder White Sponge Nevus. The type I cytokeratins are clustered in a region of chromosome 17q21.2. Alternative splicing of this gene results in multiple transcript variants\; however, not all variants have been described.
, cytokeratin 13
, keratin, type I cytoskeletal 13
, type I keratin KA13
, 47 kDa cytokeratin
, keratin complex 1, acidic, gene 13