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LIPA encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). De plus, nous expédions Lipase A Kits (12) et Lipase A Protéines (10) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 78 products:
Human Monoclonal Lipase A Primary Antibody pour ELISA, WB - ABIN969484
Drebber, Andersen, Kasper, Lohse, Stolte, Dienes: Severe chronic diarrhea and weight loss in cholesteryl ester storage disease: a case report. dans World journal of gastroenterology : WJG 2005
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Human Monoclonal Lipase A Primary Antibody pour ELISA, WB - ABIN966473
Boldrini, Devito, Biselli, Filocamo, Bosman: Wolman disease and cholesteryl ester storage disease diagnosed by histological and ultrastructural examination of intestinal and liver biopsy. dans Pathology, research and practice 2004
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Human Polyclonal Lipase A Primary Antibody pour WB - ABIN517528
Roszell, Tao, Yu, Huang, Bates: Characterization of the Niemann-Pick C pathway in alveolar type II cells and lamellar bodies of the lung. dans American journal of physiology. Lung cellular and molecular physiology 2012
Horse (Equine) Polyclonal Lipase A Primary Antibody pour WB - ABIN611571
Matsuoka, Huang, Elledge: Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. dans Science (New York, N.Y.) 1998
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Human Polyclonal Lipase A Primary Antibody pour ICC, IF - ABIN4331092
Lettieri Barbato, Tatulli, Aquilano, Ciriolo: FoxO1 controls lysosomal acid lipase in adipocytes: implication of lipophagy during nutrient restriction and metformin treatment. dans Cell death & disease 2013
Cholesterol esterase shows enantioselective inhibition for enantiomers of exo (Montrer PHM Anticorps)- and endo-2-norbornyl-N-n-butylcarbamates.
Report LIPA variants/phenotype in childhood-onset lysosomal acid lipase deficiency.
LAL activity is significantly reduced in NAFLD (Montrer TSC2 Anticorps), compared to that in HCV patients. This finding is particularly evident in the pre-cirrhotic stage of disease. LAL activity is also correlated with platelet and white blood cell count, suggesting an analytic interference of portal-hypertension-induced pancytopenia on DBS (Montrer MCF2L Anticorps)-determined LAL activity.
LAL plays a critical role in regulating mesenchymal stem cells' ability to stimulate tumor growth and metastasis, which provides a mechanistic basis for targeting LAL in MSCs to reduce the risk of cancer metastasis
Report a marked reduction of LAL activity in patients with cryptogenic cirrhosis.
LIPA mutations may have a role in with a clinical diagnosis of familial hypercholesterolemia
Use CRISPR/Cas9 techniques to knockout LIPA in human induced pluripotent stem cells and differentiate them to macrophages.
LIPA associated with Familial Hypercholesterolemia and Polygenic Hypercholesterolemia in patients with Acute Coronary Syndrome , age =65 years, and LDL-C levels >/=160 mg/dl.
Study demonstrates that liver cirrhosis from any etiology is characterized by a significant reduction of LAL activity but no known c.894G>A SNP, which is likely on an acquired base and independent from the etiology of hepatic disease.
Coronary artery disease-associated coding variant rs1051338 causes reduced lysosomal LAL protein and activity because of increased LAL degradation.
results indicate that LAL is the major acid RE hydrolase and required for functional retinoid homeostasis.
LAL is critical for shuttling fatty acids derived from circulating lipoproteins to brown adipose tissue during cold exposure.
Data show that lysosomal acid lipase (LAL)-deficient (-/-) macrophages accumulate neutral lipids, mainly cholesteryl esters, within lysosomes.
Low LAL expression is associated with tumor growth and metastasis.
The activity of lysosomal acid lipase was also decreased on treatment of macrophages with each modified LDL.
hLAL (Montrer LIPF Anticorps) expression reduced tumor-promoting myeloid-derived suppressive cells in the liver of lal(-/-) mice
Results indicate that LAL has a critical role in regulating MDSCs' ability to directly stimulate cancer cell proliferation and overcome immune rejection of cancer metastasis in allogeneic mice through modulation of the mTOR (Montrer FRAP1 Anticorps) pathway.
effect the loss of SOAT2 (Montrer SOAT2 Anticorps) function has on tissue esterified cholesterol sequestration in lysosomal acid lipase-deficient mice in a model of cholesteryl ester storage disease
Lipolysis of triacylglycerol substrates by LAL is important for M2 macrophage activation, and its inhibition suppresses M2 activation.
LAL regulates endothelial cell function through interaction with myeloid-derived suppressor cells and modulation of the mTOR (Montrer FRAP1 Anticorps) pathway, which provide mechanistic basis for targeting MDSCs or mTOR (Montrer FRAP1 Anticorps) to rejuvenate EC functions in LAL deficiency-related diseases
This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
lipase A, lysosomal acid, cholesterol esterase (Wolman disease)
, lysosomal acid lipase/cholesteryl ester hydrolase
, lipase A, lysosomal acid, cholesterol esterase
, lysosomal acid lipase/cholesteryl ester hydrolase-like
, acid cholesteryl ester hydrolase
, cholesterol ester hydrolase
, cholesteryl esterase
, lysosomal acid lipase
, sterol esterase
, Cholesterol esterase (pancreatic) see D3Wox12 D3Wox13 D3Wox26 and D3Mgh25
, lysosomal acid lipase 1
, lysosomal acid lipase A
, pancreatic cholesterol esterase
, lipase A