Lon Peptidase 1, Mitochondrial Protéines (LONP1)

LONP1 encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. De plus, nous expédions Lon Peptidase 1, Mitochondrial Anticorps (82) et et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
LONP1 9361 P36776
LONP1 74142 Q8CGK3
Rat LONP1 LONP1 170916 Q924S5
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
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Cellules d'insectes Souris His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 70 Days
$13,984.89
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Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days
$414.29
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LONP1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
,
Mouse (Murine)

Plus protéines pour Lon Peptidase 1, Mitochondrial (LONP1) partenaires d'interaction

Human Lon Peptidase 1, Mitochondrial (LONP1) interaction partners

  1. mitochondrial ATP-dependent Lon protease may serve as a potential biomarker for cancer diagnosis and novel target for the development of anticancer drugs and for predicting of the efficiency and effectiveness of chemotherapy of a variety of cancers.

  2. We demonstrate that Lon plays a key role in glioma cell hypoxic survival and mitochondrial respiration, and propose Lon as a promising therapeutic target in the treatment of malignant gliomas.

  3. Some features were not consistent with CODAS syndrome but overlapped with Marinesco-Sjogren syndrome, a multisystem disorder caused by a mutation in SIL1 (Montrer SIL1 Protéines). An atypical mutation site may result in atypical presentation of the LONP1 mutation

  4. LONP1 function and implication in human aging and disease was reviewed.

  5. we observed that Lon protease downregulation is linked to a higher lipofuscinogenesis whereas the application of the mitochondrial-targeted antioxidant mitoTEMPO is able to prevent the accumulation of this protein aggregate.

  6. Lon preferentially degrades the phosphorylated subunits of CcO (Montrer RYR1 Protéines) and plays a role in the regulation of CcO (Montrer RYR1 Protéines) activity in hypoxia and ischemia/reperfusion injury.

  7. Lon protease (Lonp1), which is a key inductive of mitochondrial unfolded protein response (UPR(mt)) and is required to maintain the mitochondrial quality, was greatly induced in H. pylori infected gastric epithelial cells.

  8. Mutations of Lon, which likely impair its chaperone properties, are at the basis of a genetic inherited disease named the cerebral, ocular, dental, auricular, skeletal (CODAS) syndrome. (Review)

  9. Inhibition of Lon protease by triterpenoids alters mitochondria and is associated to cell death in human cancer cells.

  10. Lon downregulation attenuated hypoxia-induced cardiomyocyte apoptosis through a reduction of reactive oxygen species level.

Mouse (Murine) Lon Peptidase 1, Mitochondrial (LONP1) interaction partners

  1. these findings suggest that Lon protease may be particularly vulnerable to inactivation in conditions associated with elevated oxidative stress resulting in mitochondrial dysfunction and neuron cell death, an early event in the pathogenesis of Parkinson's disease

  2. Lon preferentially degrades the phosphorylated subunits of CcO (Montrer RYR1 Protéines) and plays a role in the regulation of CcO (Montrer RYR1 Protéines) activity in hypoxia and ischemia/reperfusion injury.

  3. Lon protease (Lonp1), which is a key inductive of mitochondrial unfolded protein response (UPR(mt)) and is required to maintain the mitochondrial quality, was greatly induced in H. pylori infected gastric epithelial cells.

  4. LONP1 knockdown inhibits cellular proliferation and tumor and metastasis formation, whereas its overexpression increases tumorigenesis.

  5. Epidermal growth factor (Montrer EGF Protéines) up-regulates the transcription of ATP-dependent protease through extracellular signal-regulated protein kinase (Montrer CDK7 Protéines)- and 1-phosphatidylinositol 3-kinase (Montrer PIK3CG Protéines)-dependent pathways.

  6. Modulation of Lon protease activity during aging and oxidative stress.

  7. The correlative effect of Lon and ClpP (Montrer CLPP Protéines) upregulation on loss of mitochondrial Fe-S proteins during the progression of the disease may suggest that Fe-S proteins are potential targets of Lon and ClpP (Montrer CLPP Protéines) proteases in FRDA (Montrer FXN Protéines).

Profil protéine Lon Peptidase 1, Mitochondrial (LONP1)

Profil protéine

This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with LONP1

  • lon peptidase 1, mitochondrial (LONP1)
  • lon peptidase 1, mitochondrial (lonp1)
  • lon peptidase 1, mitochondrial (Lonp1)
  • ATP-dependent Lon protease (PIM1)
  • 1200017E13Rik Protéine
  • fc64d11 Protéine
  • hLON Protéine
  • Lon Protéine
  • LonHS Protéine
  • LONP Protéine
  • PIM1 Protéine
  • Prss15 Protéine
  • wu:fc64d11 Protéine

Protein level used designations for LONP1

lon peptidase 1, mitochondrial , protease, serine, 15 , lon protease homolog, mitochondrial-like , hLON ATP-dependent protease , lon protease homolog, mitochondrial , mitochondrial ATP-dependent protease Lon , mitochondrial lon protease-like protein , serine protease 15 , LONP , lon protease-like protein , ATP-dependent Lon protease , hypothetical protein

GENE ID SPECIES
455623 Pan troglodytes
563257 Danio rerio
100024990 Monodelphis domestica
100074993 Ornithorhynchus anatinus
100408135 Callithrix jacchus
100468447 Ailuropoda melanoleuca
100538450 Meleagris gallopavo
100590941 Nomascus leucogenys
9361 Homo sapiens
74142 Mus musculus
170916 Rattus norvegicus
768942 Gallus gallus
611425 Canis lupus familiaris
100511917 Sus scrofa
510796 Bos taurus
3640999 Candida albicans SC5314
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