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MRVI1 is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). De plus, nous expédions Murine Retrovirus Integration Site 1 Homolog Kits (3) et Murine Retrovirus Integration Site 1 Homolog Protéines (3) et beaucoup plus de produits pour cette protéine.
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This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used.
JAW1-related protein MRVI1
, inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate
, inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate
, murine retrovirus integration site 1 protein
, protein MRVI1
, retroviral integration site 1
, IP3R-associated cGMP kinase substrate
, IP3 receptor associated cGMP kinase substrate